Publication	Data		Fish	Anatomy
Auman et al., 2023	Fig. 8		tnnt2ab109/b109	heart notch1b expression spatial pattern, abnormal
Vignes et al., 2022	Fig. 4		tnnt2atc300b/tc300b; y7Tg/y7Tg ,   y7Tg/y7Tg + MO1-tnnt2a	atrioventricular canal blood circulation decreased process quality, abnormal atrioventricular canal cytoskeleton organization decreased process quality, abnormal atrioventricular canal Golgi organization decreased process quality, abnormal atrioventricular canal nucleus EGFP expression decreased amount, abnormal atrioventricular canal nucleus EGFP expression spatial pattern, abnormal atrioventricular canal regulation of cell size decreased process quality, abnormal
Kamel et al., 2021	Figure 1		tnnt2ahu11320/+ (TL) ,   tnnt2ahu11320/hu11320 (TL)	heart increased size, abnormal heart morphology, abnormal heart protruding, abnormal whole organism dead, abnormal whole organism decreased length, abnormal whole organism decreased life span, abnormal
	Figure 2		tnnt2ahu11320/+ (TL)	atrium hyperplastic, abnormal atrium increased size, abnormal atrium myocardium increased thickness, abnormal cardiac ventricle decreased size, abnormal
	Figure 3		tnnt2ahu11320/+ (TL)	atrium nppb expression increased amount, abnormal atrium nppb expression increased distribution, abnormal atrium Collagen increased amount, abnormal atrium Fibrin increased amount, abnormal atrium Fibrin increased distribution, abnormal atrium lateral margin col6a1 expression increased distribution, abnormal atrium lateral margin postnb expression increased distribution, abnormal cardiac ventricle lateral margin col6a1 expression increased distribution, abnormal cardiac ventricle lateral margin postnb expression increased distribution, abnormal
	Figure 4		tnnt2ahu11320/+ (TL)	heart contraction decreased rate, abnormal
	Figure 5		tnnt2ahu11320/+; ccu1Tg; hu6531Tg (TL)	heart intracellular calcium ion homeostasis process quality, abnormal
	text only		tnnt2ahu11320/+ (TL) ,   tnnt2ahu11260/hu11260 (TL) ,   tnnt2ahu11320/hu11320 (TL)	female organism oocyte development decreased process quality, abnormal heart contraction absent process, abnormal heart contraction decreased rate, abnormal heart looping disrupted, abnormal pericardium edematous, abnormal swimming behavior process quality, abnormal
Paolini et al., 2021	Figure 1		nkuasgfp1aTg; pbb65Tg + MO1-tnnt2a	atrioventricular canal endocardium EGFP expression decreased amount, abnormal atrioventricular valve formation decreased process quality, abnormal blood circulation arrested, abnormal heart contraction arrested, abnormal
Yue et al., 2021	Fig. 3		sd2Tg/sd2Tg; y1Tg/y1Tg + MO1-tnnt2a	subintestinal venous plexus EGFP expression spatial pattern, abnormal subintestinal venous plexus morphogenesis of a branching structure decreased process quality, abnormal
	Fig. 7		sd2Tg/sd2Tg; y1Tg/y1Tg + MO1-tnnt2a	ocular blood vessel blood vessel lumenization decreased process quality, abnormal ocular blood vessel EGFP expression spatial pattern, abnormal ocular blood vessel morphogenesis of a branching structure decreased process quality, abnormal
Fontana et al., 2020	Fig. 1		WT + MO1-tnnt2a ,   hu7135Tg + MO1-tnnt2a	atrioventricular canal Venus expression decreased amount, abnormal cardiac ventricle Venus expression decreased amount, abnormal heart flt1 expression decreased amount, abnormal heart flt4 expression increased amount, abnormal heart heg1 expression decreased amount, abnormal heart notch1b expression decreased amount, abnormal heart Citrine expression decreased amount, abnormal heart Citrine expression increased amount, abnormal
Duchemin et al., 2019	Figure 6		um14Tg + MO1-tnnt2a ,   ig11Tg; ubs10Tg + MO1-tnnt2a ,   zf495Tg + MO1-tnnt2a	bulbus arteriosus decreased diameter, abnormal bulbus arteriosus endocardial cushion EGFP expression spatial pattern, abnormal bulbus arteriosus lacks all parts of type ventriculo bulbo valve, abnormal bulbus arteriosus smooth muscle tissue development decreased process quality, abnormal bulbus arteriosus vascular smooth muscle yap1 expression decreased amount, abnormal bulbus arteriosus vascular smooth muscle ab1-elnb labeling decreased amount, abnormal bulbus arteriosus vascular smooth muscle ab2-fn labeling decreased amount, abnormal heart contraction decreased frequency, abnormal
Liu et al., 2019	Fig. 1.		tnnt2afdu108/fdu108; fdu107Tg ,   tnnt2afdu108/fdu108; twu34Tg	atrium distended, abnormal cardiac ventricle distended, abnormal heart contraction arrested, abnormal heart muscle contraction arrested, abnormal pericardium edematous, abnormal
Rödel et al., 2019	Fig. 1		s843Tg + MO1-tnnt2a	caudal vein plexus morphology, abnormal intersegmental vessel morphology, abnormal lateral dorsal aorta morphology, abnormal
	Fig. 2		mu107Tg + MO1-tnnt2a	blood circulation decreased occurrence, abnormal lateral dorsal aorta Citrine expression absent, abnormal
	Fig. Online I		s843Tg + MO1-tnnt2a	caudal vein plexus fused with caudal vein plexus, abnormal central artery angiogenic sprout increased amount, abnormal heart decreased size, abnormal intersegmental vessel collapsed, abnormal intersegmental vessel decreased size, abnormal
Donat et al., 2018	Fig. 1		WT + MO1-tnnt2a	blood circulation arrested, abnormal whole organism heg1 expression decreased amount, abnormal
Rasouli et al., 2018	Fig. 2		s974Tg + MO1-tnnt2a	atrium cardiac muscle contraction arrested, abnormal cardiac ventricle cardiac muscle contraction arrested, abnormal
Xie et al., 2018	Fig. 1		s843Tg + MO1-tnnt2a	caudal vein plexus malformed, abnormal caudal vein plexus sprouting angiogenesis decreased occurrence, abnormal
	Fig. 4		WT + MO1-tnnt2a	caudal vein plexus klf2a expression decreased distribution, abnormal
	Fig. 5		WT + MO1-tnnt2a ,   s843Tg + MO1-tnnt2a	caudal vein plexus kdrl expression decreased distribution, abnormal caudal vein plexus malformed, abnormal caudal vein plexus sprouting angiogenesis decreased occurrence, abnormal
Zhan et al., 2018	Fig. 4		tnnt2aswu77/swu77; s843Tg	blood vessel endothelial cell delamination decreased rate, abnormal
Chen et al., 2017	Fig. 2		s843Tg; uto5Tg + MO1-tnnt2a	blood circulation decreased rate, abnormal dorsal aorta anatomical region mCherry expression absent, abnormal dorsal aorta vascular associated smooth muscle cell decreased amount, abnormal dorsal aorta vascular associated smooth muscle cell mCherry expression absent, abnormal
	Fig. 6		WT + MO1-tnnt2a	whole organism foxc1a expression decreased amount, abnormal whole organism foxc1b expression decreased amount, abnormal
Goddard et al., 2017	Fig. 7		tnnt2atc300b/tc300b	atrioventricular valve wnt9b expression absent, abnormal bulbus arteriosus wnt9b expression absent, abnormal
Rasouli et al., 2017	Fig. 6		zf517Tg + MO1-tnnt2a	cardiac muscle cell basal side EGFP expression absent, abnormal cardiac muscle cell EGFP expression mislocalised, abnormal
Serbanovic-Canic et al., 2017	Fig. 1		ubs1Tg + MO1-tnnt2a	blood circulation decreased occurrence, abnormal endothelial cell apoptotic process increased occurrence, abnormal
	Fig. 5		ubs1Tg + MO1-tnnt2a	blood circulation decreased occurrence, abnormal endothelial cell apoptotic process increased occurrence, abnormal
	Fig. 6		ubs1Tg + MO1-tnnt2a ,   ubs1Tg + MO1-tnnt2a + MO4-tp53	endothelial cell apoptotic process increased occurrence, abnormal endothelial cell apoptotic process increased occurrence, ameliorated
Jiménez-Amilburu et al., 2016	Fig. 6		s940Tg + MO1-tnnt2a	atrioventricular valve Venus expression absent, abnormal cardiac muscle cell Notch signaling pathway decreased process quality, abnormal cardiac muscle cell Venus expression absent, abnormal heart Notch signaling pathway decreased process quality, abnormal
Poon et al., 2016	Fig. 4		f2Tg; sqet33mi28Et + MO1-tnnt2a ,   f2Tg; sqet33mi59BEt + MO1-tnnt2a	cardiac conduction system mislocalised, abnormal sinoatrial node EGFP expression increased distribution, abnormal sinoatrial node increased area, abnormal
Rochon et al., 2016	Fig. 4		rk8Tg; ubs4Tg + MO1-tnnt2a	aortic arch 1 blood vessel endothelial cell migration process quality, abnormal aortic arch 1 cell migration involved in heart development decreased occurrence, abnormal blood circulation decreased occurrence, abnormal caudal division of the internal carotid artery blood vessel endothelial cell migration process quality, abnormal cell migration involved in heart development decreased occurrence, abnormal internal carotid artery blood vessel endothelial cell migration process quality, abnormal
Steed et al., 2016	Fig. 5		tnnt2atc300b/tc300b; y7Tg	atrioventricular canal ab2-fn labeling decreased amount, abnormal
Xu et al., 2016	Fig. 2		hkz011tTg; tsu11Tg + MO1-tnnt2a	heart contraction decreased occurrence, abnormal optic tectum decreased width, abnormal optic tectum microglial cell decreased amount, abnormal optic tectum microglial cell migration process quality, abnormal
Andersen et al., 2015	Fig. 2		f2Tg + MO1-tnnt2a	heart contraction arrested, abnormal
	Fig. 5		f2Tg + MO1-tnnt2a	heart contraction arrested, abnormal
Heckel et al., 2015	Fig. 4		tnnt2atc300b/tc300b; ubs3Tg; zf350Tg ,   ubs3Tg; zf350Tg + MO1-tnnt2a	atrioventricular canal GCaMP expression decreased amount, abnormal
Novodvorsky et al., 2015	Fig. S1		WT + MO1-tnnt2a	trunk vasculature klf2a expression decreased amount, abnormal
	Fig. S5		WT + MO1-tnnt2a	ventral wall of dorsal aorta hematopoietic stem cell myb expression decreased amount, abnormal ventral wall of dorsal aorta hematopoietic stem cell runx1 expression decreased amount, abnormal
Renz et al., 2015	Fig. 5		s843Tg + MO1-tnnt2a	endocardium hypotrophic, abnormal
Samsa et al., 2015	Fig. 1		s843Tg; vc6Tg + MO1-tnnt2a	cardiac ventricle trabecular layer absent, abnormal heart contraction absent, abnormal trabecular layer absent, abnormal
	Fig. 2		um14Tg; vc6Tg + MO1-tnnt2a ,   tnnt2ab109/b109	heart notch1b expression absent, abnormal heart contraction absent, abnormal heart EGFP expression absent, abnormal Notch signaling involved in heart development decreased occurrence, abnormal
	Fig. 4		twu26Tg + MO1-tnnt2a	heart efnb2a expression decreased amount, abnormal heart notch1b expression decreased amount, abnormal heart nrg1 expression decreased amount, abnormal
Wu et al., 2015	Fig. 7		la116Tg + MO1-tnnt2a	subintestinal vein blood vessel morphogenesis disrupted, abnormal subintestinal vein morphology, abnormal
Chou et al., 2014	Fig. 1		li1Tg + MO1-tnnt2a	adrenal gland development process quality, abnormal blood circulation decreased process quality, abnormal heart contraction decreased process quality, abnormal interrenal gland position, abnormal pronephric glomerulus morphogenesis process quality, abnormal pronephric glomerulus separated from pronephric glomerulus, abnormal
	Fig. 6		zf346Tg + MO1-tnnt2a	interrenal gland epithelial to mesenchymal transition decreased occurrence, abnormal
	Fig. 7		WT + MO1-tnnt2a	adrenal gland development process quality, abnormal chromaffin cell mislocalised, abnormal interrenal gland animal organ morphogenesis process quality, abnormal
Gerlach et al., 2014	Fig. 8		TU + MO1-tnnt2a	heart contraction arrested, abnormal
Mleynek et al., 2014	Fig. 7		s843Tg + MO1-tnnt2a	blood vessel morphogenesis decreased process quality, abnormal caudal vein plexus angiogenic sprout increased amount, abnormal caudal vein plexus sprouting angiogenesis increased occurrence, abnormal post-vent vasculature morphology, abnormal
Sauteur et al., 2014	Fig. S1		y1Tg + MO1-tnnt2a	intersegmental vessel blood vessel lumenization process quality, abnormal
Sawamiphak et al., 2014	Fig. 5		la2Tg; s896Tg + MO1-tnnt2a	ventral wall of dorsal aorta has fewer parts of type hematopoietic stem cell, abnormal
Staudt et al., 2014	Fig. 5		s883Tg + MO1-tnnt2a	cardiac muscle cell cell projection transient, abnormal
Helker et al., 2013	Fig. 8		WT + MO1-tnnt2a	common cardinal vein blood vessel endothelial cell decreased amount, abnormal nucleate erythrocyte development disrupted, abnormal
Mugoni et al., 2013	Fig. 6		s843Tg + MO1-tnnt2a	intersegmental vessel structure, abnormal
	Fig. S1		WT + MO1-tnnt2a ,   s843Tg + MO1-tnnt2a	brain vasculature hemorrhagic, abnormal heart morphology, abnormal intersegmental vessel structure, abnormal trunk vasculature morphology, abnormal
Zhao et al., 2013	Fig. S4		zn1Tg + MO1-tnnt2a	trunk vasculature blood vessel lumenization decreased process quality, abnormal
Chen et al., 2012	Fig. S13		s843Tg + MO1-tnnt2a	blood vessel remodeling disrupted, abnormal midbrain blood vasculature has fewer parts of type blood vessel, abnormal midbrain blood vasculature morphology, abnormal
Chiu et al., 2012	Fig. 8		s843Tg + MO1-tnnt2a	blood circulation disrupted, abnormal interrenal angiogenic sprout mislocalised laterally, abnormal interrenal primordium position, abnormal
Ellertsdottir et al., 2012	Fig. 4		s843Tg; sd2Tg + MO1-tnnt2a	blood circulation arrested, abnormal blood increased accumulation caudal vein, abnormal blood vessel lumenization disrupted, abnormal dorsal aorta structure, abnormal intersegmental vessel structure, cavities, abnormal
Ichimura et al., 2012	Fig. 4		WT + MO1-tnnt2a	dorsal aorta dilated, abnormal pronephric glomerulus hypoplastic, abnormal pronephric glomerulus lacks all parts of type pronephric glomerular capillary, abnormal pronephric glomerulus morphology, abnormal pronephric glomerulus unfused from pronephric glomerulus, abnormal pronephros development process quality, abnormal
	Fig. 6		WT + MO1-tnnt2a	pronephric glomerulus disorganized, abnormal
	Fig. 7		WT + MO1-tnnt2a	dorsal aorta dilated, abnormal pronephric glomerulus disorganized, abnormal pronephric glomerulus hypoplastic, abnormal pronephric glomerulus unfused from pronephric glomerulus, abnormal pronephric podocyte nphs1 expression spatial pattern, abnormal
Yang et al., 2012	Fig. 7		WT + MO1-tnnt2a	cardiac muscle cell sarcomere disorganized, abnormal
Becker et al., 2011	Fig. 2		WT + MO3-tnnt2a	atrium dilated, abnormal cardiac ventricle decreased diameter, abnormal cardiac ventricle decreased functionality, abnormal cardiac ventricle decreased size, abnormal pericardium edematous, abnormal
	Fig. 3		f2Tg + MO3-tnnt2a ,   WT + MO3-tnnt2a	cardiac muscle cell decreased area, abnormal cardiac muscle cell increased amount, abnormal ventricular myocardium sarcomere disorganized, abnormal
	Fig. 4		WT + MO1-tnnt2a ,   WT + MO3-tnnt2a	cardiac muscle cell electric potential, abnormal regulation of cardiac muscle contraction by calcium ion signaling disrupted, abnormal
	Fig. 5		WT + MO3-tnnt2a	hormone activity decreased occurrence, abnormal
Bussmann et al., 2011	Fig. 6		WT + MO1-tnnt2a	blood circulation arrested, abnormal central artery physical object quality, abnormal sprouting angiogenesis process quality, abnormal
Clark et al., 2011	Fig. Table 1		tnnt2amn0031Gt/mn0031Gt	heart contraction arrested, abnormal heart non-functional, abnormal whole organism viability, abnormal
Corti et al., 2011	Fig. 1		pt505Tg; y7Tg + MO1-tnnt2a	blood vessel collapsed, abnormal
Fujita et al., 2011	Fig. 3		y1Tg + MO1-tnnt2a	basilar artery decreased diameter, abnormal blood circulation absent, abnormal central artery decreased diameter, abnormal
Wang et al., 2011	Fig. 1		la116Tg; sd2Tg + MO1-tnnt2a	blood accumulation trunk, abnormal
	Fig. 2		WT + MO1-tnnt2a	blood accumulation trunk, abnormal thymus decreased size, abnormal thymus hematopoietic multipotent progenitor cell decreased amount, abnormal trunk hematopoietic multipotent progenitor cell decreased amount, abnormal
	Fig. 4		WT + MO1-tnnt2a	artery morphogenesis delayed, abnormal dorsal aorta unlumenized, abnormal
	Fig. 5		WT + MO1-tnnt2a	trunk hematopoietic multipotent progenitor cell decreased amount, abnormal
	Fig. 7		WT + MO1-tnnt2a	hematopoietic multipotent progenitor cell decreased amount, abnormal nitric oxide biosynthetic process disrupted, abnormal
Chi et al., 2010	Fig. 2		tnnt2ab109/b109; s878Tg	heart contraction arrested, abnormal
Chou et al., 2010	Fig. 2		y1Tg + MO1-tnnt2a	adrenal gland development lacking processual parts cell migration, abnormal pronephric glomerular capillary increased size, abnormal pronephric glomerulus right side unfused from pronephric glomerulus left side, abnormal vascular endothelium increased size, abnormal vascular endothelium mislocalised, abnormal
Wang et al., 2010	Fig. 4		tnnt2amn0031Gt/mn0031Gt; is1Tg	blood circulation arrested, abnormal blood vessel lumenization process quality, abnormal intersegmental vessel unlumenized, abnormal
Herbert et al., 2009	Fig. 1		WT + MO1-tnnt2a	anterior cardinal vein unlumenized, abnormal blood circulation arrested, abnormal posterior cardinal vein unlumenized, abnormal venous blood vessel morphogenesis disrupted, abnormal
North et al., 2009	Fig. 2		tnnt2aunspecified/unspecified	blood accumulation blood vasculature, abnormal heart contraction absent, abnormal hematopoietic stem cell decreased amount, abnormal
Vasilyev et al., 2009	Fig. 8		sqet11Et + MO1-tnnt2a ,   sqet33D10Et + MO1-tnnt2a (AB)	distal tubule development arrested, abnormal proximal convoluted tubule development arrested, abnormal simple columnar epithelium displaced, abnormal simple cuboidal epithelium displaced, abnormal
Anderson et al., 2008	Fig. 4		WT + MO1-tnnt2a	basibranchial condensed, abnormal ceratobranchial cartilage orientation ceratobranchial cartilage, abnormal ceratohyal cartilage orientation ceratohyal cartilage, abnormal palatoquadrate arch decreased length, abnormal
Chi et al., 2008	Fig. 6		tnnt2ab109/b109; s843Tg ,   tnnt2ab109/b109; s878Tg	calcium-mediated signaling disrupted, abnormal trabecular layer aplastic, abnormal
	Fig. 7		tnnt2ab109/b109; s878Tg	regulation of cardiac muscle contraction disrupted, abnormal
Hogan et al., 2008	Fig. S1		y1Tg + MO1-tnnt2a	blood circulation disrupted, abnormal
	Fig. S3		y1Tg + MO1-tnnt2a	cranial vasculature unlumenized, abnormal
	Fig. S6		y1Tg + MO1-tnnt2a	caudal vein plexus decreased size, abnormal
Korzh et al., 2008	Fig. 5		gz15Tg; y1Tg + MO1-tnnt2a ,   gz15Tg/gz15Tg + MO1-tnnt2a	pericardium edematous, abnormal
	Fig. 6		gz15Tg; y1Tg + MO1-tnnt2a ,   gz15Tg/gz15Tg + MO1-tnnt2a	hepatic sinusoid aplastic, abnormal liver decreased size, abnormal
Serluca, 2008	Fig. 6		WT + MO1-tnnt2a	pericardium edematous, abnormal
Xie et al., 2008	Fig. 3		la2042Tg + MO1-tnnt2a	pericardium edematous, abnormal
Arnaout et al., 2007	Fig. 4		s878Tg + MO1-tnnt2a	heart contraction arrested, abnormal
Murayama et al., 2006	Fig. 7		AB + MO1-tnnt2a	blood circulation disrupted, abnormal blood flow rate, abnormal hematopoietic system decreased functionality, abnormal trunk anterior side increased accumulation nucleate erythrocyte, abnormal
Phenotype Annotation (1994-2006)	Fig. for (b109)		tnnt2ab109/b109 (AB)	brain quality, abnormal heart quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tc300b)		tnnt2atc300b/tc300b	anatomical system quality, abnormal heart quality, abnormal whole organism lethal (sensu genetics), abnormal
Serluca et al., 2002	Fig. 1		tnnt2atc300b	blood circulation arrested, abnormal heart contraction arrested, abnormal pronephric glomerulus unfused from pronephric glomerulus, abnormal
Kikuchi et al., 2000	Fig. 1		tnnt2atc300b/tc300b	pericardium edematous, abnormal
Chen et al., 1996	Fig. 6		tnnt2atc300b/tc300b	atrium increased size, abnormal heart contraction arrested, abnormal heart non-contractile, abnormal
	Table 1		tnnt2ab109/b109	heart contraction arrested, abnormal heart non-contractile, abnormal
Schier et al., 1996	Fig. 7		tnnt2ab109/b109 (AB)	fourth ventricle decreased diameter, abnormal ventricular system decreased size, abnormal
	Fig. 8		tnnt2ab109/b109 (AB)	brain decreased size, abnormal ventricular system decreased size, abnormal