Gene

tnnt2a

ID
ZDB-GENE-000626-1
Name
troponin T type 2a (cardiac)
Symbol
tnnt2a Nomenclature History
Previous Names
  • ctnnt (1)
  • cTnT
  • tnnt2
  • sih
  • silent heart
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have cytoskeletal protein binding activity and protein-macromolecule adaptor activity. Involved in several processes, including animal organ development; circulatory system development; and nitric oxide biosynthetic process. Localizes to troponin complex. Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).
Genome Resources
Note
None
Expression
All Expression Data
24 figures from 16 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
87 figures from 59 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnnt2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1D Alliance Cardiomyopathy, dilated, 1D 601494
dilated cardiomyopathy 1D Alliance Left ventricular noncompaction 6 601494
hypertrophic cardiomyopathy 2 Alliance Cardiomyopathy, hypertrophic, 2 115195
restrictive cardiomyopathy 3 Alliance Cardiomyopathy, familial restrictive, 3 612422
Associated With tnnt2a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001978 Troponin
Family IPR027707 Troponin T
Homologous_superfamily IPR038077 Troponin domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tnnt2 monoclonal IgG Mouse
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations