Gene

tnnt2a

ID

ZDB-GENE-000626-1

Name

troponin T type 2a (cardiac)

Symbol

tnnt2a Nomenclature History

Previous Names

ctnnt (1)
cTnT
tnnt2
sih
silent heart

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to contribute to calcium-dependent ATPase activity and tropomyosin binding activity. Involved in several processes, including animal organ development; circulatory system development; and nitric oxide biosynthetic process. Localizes to troponin complex. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Orthologous to human TNNT2 (troponin T2, cardiac type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

34 figures from 24 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu662 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 103 figures from 67 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnnt2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1D	Alliance	Cardiomyopathy, dilated, 1D	601494
dilated cardiomyopathy 1D	Alliance	Left ventricular noncompaction 6	601494
hypertrophic cardiomyopathy 2	Alliance	Cardiomyopathy, hypertrophic, 2	115195
restrictive cardiomyopathy 3	Alliance	Cardiomyopathy, familial restrictive, 3	612422

Associated With tnnt2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
cardiomyopathy	tnnt2a^{fdu108/fdu108}	standard conditions	Liu et al., 2019
hypertrophic cardiomyopathy	bw6Tg + MO3-tnnt2a	control	Becker et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001978	Troponin
Family	IPR027707	Troponin T
Homologous_superfamily	IPR038077	Troponin domain superfamily

Domain Details Per Protein

Protein	Length	Troponin	Troponin domain superfamily	Troponin T
UniProtKB:F1R0K6 InterPro	264
UniProtKB:A0A8M9PWK7 InterPro	272
UniProtKB:Q90Y46 InterPro	282

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tnnt2a-001 (1)	Havana	866 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnnt2a-201 (1) Ensembl	Ensembl	795 nt	Select Tool ZFIN BLAST
mRNA	tnnt2a-202 (1) Ensembl	Ensembl	849 nt	Select Tool ZFIN BLAST
mRNA	tnnt2a-203 (1) Ensembl	Ensembl	693 nt	Select Tool ZFIN BLAST
mRNA	tnnt2a-204 (1) Ensembl	Ensembl	1,176 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tnnt2	monoclonal	tnnt2a	IgG	Mouse	IHC	Developmental Studies Hybridoma Bank	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations