Gene
tnnt2a
- ID
- ZDB-GENE-000626-1
- Name
- troponin T type 2a (cardiac)
- Symbol
- tnnt2a Nomenclature History
- Previous Names
-
- ctnnt (1)
- cTnT
- tnnt2
- sih
- silent heart
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have cytoskeletal protein binding activity and protein-macromolecule adaptor activity. Involved in several processes, including animal organ development; circulatory system development; and nitric oxide biosynthetic process. Localizes to troponin complex. Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 33 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu662 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 102 figures from 66 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
dilated cardiomyopathy 1D | Alliance | Cardiomyopathy, dilated, 1D | 601494 |
dilated cardiomyopathy 1D | Alliance | Left ventricular noncompaction 6 | 601494 |
hypertrophic cardiomyopathy 2 | Alliance | Cardiomyopathy, hypertrophic, 2 | 115195 |
restrictive cardiomyopathy 3 | Alliance | Cardiomyopathy, familial restrictive, 3 | 612422 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
cardiomyopathy | tnnt2afdu108/fdu108 | standard conditions | Liu et al., 2019 |
hypertrophic cardiomyopathy | bw6Tg + MO3-tnnt2a | control | Becker et al., 2012 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Troponin | Troponin domain superfamily | Troponin T |
---|---|---|---|---|
UniProtKB:F1R0K6
|
264 | |||
UniProtKB:A0A8M9PWK7
|
272 | |||
UniProtKB:Q90Y46
|
282 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA | tnnt2a-001 (1) | Havana | 866 nt | ||
mRNA |
tnnt2a-201
(1)
|
Ensembl | 795 nt | ||
mRNA |
tnnt2a-202
(1)
|
Ensembl | 849 nt | ||
mRNA |
tnnt2a-203
(1)
|
Ensembl | 693 nt | ||
mRNA |
tnnt2a-204
(1)
|
Ensembl | 1,176 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-tnnt2 | monoclonal | IgG | Mouse |
|
Developmental Studies Hybridoma Bank
|
3 |
Plasmids
No data available