ZFIN ID: ZDB-GENE-000626-1
Gene Name: troponin T type 2a (cardiac)
Gene Symbol: tnnt2a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cTnT, tnnt2, sih, silent heart

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to contribute to calcium-dependent ATPase activity and tropomyosin binding activity. Involved in several processes, including animal organ development; circulatory system development; and nitric oxide biosynthetic process. Localizes to troponin complex. Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).
Genome Resources: Alliance (1),  Gene:58071 (1),  Ensembl(GRCz11):ENSDARG00000020610 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b109 Small Deletion Unknown Unknown G_RAYS
fdu108 Small Deletion Unknown Unknown CRISPR
hu5753 Unknown Unknown Unknown
mn0031Gt Transgenic Insertion Unknown Unknown DNA
sa24250 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc300b Point Mutation Acceptor Splice Site of Exon 3 Splice Site, Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tnnt2a_unspecified Unspecified Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tnnt2a
    1
    CRISPR2-tnnt2a
    1
    CRISPR3-tnnt2a
    1
    CRISPR4-tnnt2a
    1
    CRISPR5-tnnt2a
    1
    CRISPR6-tnnt2a 2
    MO1-tnnt2a N/A 131
    MO2-tnnt2a N/A 2
    MO3-tnnt2a N/A 2
    MO4-tnnt2a N/A 1
    PHENOTYPE
    Data: 84 figures from 56 publications
    Observed in:
    DISEASE ASSOCIATED WITH tnnt2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1D Alliance Cardiomyopathy, dilated, 1D 601494
    Left ventricular noncompaction 6 601494
    hypertrophic cardiomyopathy 2 Alliance Cardiomyopathy, hypertrophic, 2 115195
    restrictive cardiomyopathy 3 Alliance Cardiomyopathy, familial restrictive, 3 612422
    DISEASE ASSOCIATED WITH tnnt2a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hypertrophic cardiomyopathy bw6Tg + MO3-tnnt2a control Becker et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of nitric oxide mediated signal transduction (more)
    Cellular Component troponin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 36)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnnt2a-001 (1) 866
    tnnt2a-203 (1)    Ensembl 693
    tnnt2a-204 (1)    Ensembl 1176
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tnnt2 monoclonal IgG Mouse IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnnt2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(myl7:tet3g,tetre:tnnt2a-2a-mkate2,myl7:egfp) myl7TETRE 2AEGFPmKate2TET3Gtnnt2a Danio rerio 1 1
    Tg(tnnt2a:Cre-ERT2,Xla.Crygc:mRFP) tnnt2a CreERT2mRFP Danio rerioXenopus laevis 1 1
    Tg(tnnt2a:EGFP) tnnt2a EGFP Danio rerio 1 1
    Tg(tnnt2a:EGFP-lmna) tnnt2a EGFPlmna Danio rerio 1 1
    Tg(tnnt2a:EGFP-lmna_M368K) tnnt2a EGFPlmna Danio rerio 1 1
    Tg(tnnt2a:EGFP-lmna_Q291P) tnnt2a EGFPlmna Danio rerio 1 1
    MARKER RELATIONSHIPS
    tnnt2a Contained in: [BAC] CH73-187I15 (1)
    [PAC] BUSM1-65I4 (1), BUSM1-182N13 (1)
    tnnt2a Contains: [SNP] rs3729228 (1), rs3729229 (1), rs3729230 (1), rs3729231 (1), rs3729232 (1)
    tnnt2a Encodes: [EST] eu662 (1), zeh0954
    [cDNA] MGC:123151 (1), MGC:171408 (1), MGC:174148 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152893 (1) 1047 nt
    Genomic GenBank:AL662880 (1) 103409 nt
    Select Tool
    Polypeptide UniProtKB:A8E586 (1) 282 aa
    Sequence Information (all 41)
    ORTHOLOGY for tnnt2a ( Chr: 23 )
    CITATIONS (236)