FIGURE

Fig. 4

ID

ZDB-FIG-071006-3

Publication

Arnaout et al., 2007 - Zebrafish model for human long QT syndrome

Other Figures

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Fig. 4

Wild-type embryonic hearts in the Tg(cmlc2:gCaMP)^s878 background exhibit atrial and ventricular conduction waves, whereas mutant hearts exhibit atrial, but no ventricular, conduction waves. SPIM videos of live 48 hpf hearts in the Tg(cmlc2:gCaMP)^s878 background (see SI Movies 3 and 4) were processed to determine the fluorescence intensity of selected regions of the heart over time. Each selected region has a corresponding number plotted below. The dotted lines mark an arbitrary point in time to facilitate comparison across the different plots. (a) In a wild-type heart, fluorescence intensity varies with time in atrial and ventricular regions of the heart as the wave of depolarization propagates through the heart. This wave represents a wild-type heart rhythm. (b) In a kcnh2^s290 mutant heart, fluorescence intensity varies in the atrium, but the ventricle maintains a constant, low-level intensity. The mutant heart lacks a ventricular conduction wave.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s878Tg + MO1-tnnt2a kcnh6a^s290/s290; s878Tg + MO1-tnnt2a
Knockdown Reagent:	MO1-tnnt2a
Observed In:	cardiac ventricle heart contraction
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA