FIGURE

Fig. 6

ID

ZDB-FIG-130109-11

Publication

Ichimura et al., 2012 - Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant

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Fig. 6

Podocyte foot processes are formed in mpp5a^m520 mutants and tnnt2a-ATG morphants. A, B: In wild-type siblings, foot processes with SD are vigorously formed by 4 dpf. In 4-dpf mpp5a^m520 mutants (C, D) and tnnt2a-ATG morphants (E, F) podocytes form regular foot processes with SD by 4 dpf as observed in the wild-type siblings. In most podocytes, multiple microvillus-like processes have protruded from the apical surface of the cell body and extend into the Bowman′s space (arrows in D, F). In addition, they form regular foot processes adhering to the GBM (arrowheads in B, D, F). These microvillus-like processes are connected to each other by SD-like structures. P, podocyte. Scale bar = 500 nm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pals1a^m520/m520 WT + MO1-tnnt2a
Knockdown Reagent:	MO1-tnnt2a
Observed In:	pronephric glomerulus pronephric podocyte podocyte foot pronephric podocyte slit diaphragm
Stage:	Day 4

Phenotype Detail

Acknowledgments

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