ZFIN ID: ZDB-FIG-130109-9
Ichimura et al., 2012 - Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant. Developmental dynamics : an official publication of the American Association of Anatomists   241(12):1922-1932 Full text @ Dev. Dyn.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Day 4

Fig. 4 mpp5am520 mutants and tnnt2a-ATG morphants display a similar structural disorganization of pronephric glomerulus. A: In 4-dpf wild-type embryos, the pronephric glomerulus contains several glomerular capillaries together with mesangium, which is arborized in shape. Podocytes and GBM cover the glomerular capillaries and mesangium en bloc. In both 4-dpf mpp5am520 mutants (B) and tnnt2a-ATG morphants (C), the extremely dilated dorsal aorta (DA) lies between a pair of glomerular primordia, which do not contain any fine glomerular capillaries or mesangium. NC, notochord. Scale bar = 500 nm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-tnnt2a standard conditions Day 4 dorsal aorta dilated, abnormal
Day 4 pronephric glomerulus hypoplastic, abnormal
Day 4 pronephric glomerulus lacks all parts of type pronephric glomerular capillary, abnormal
Day 4 pronephric glomerulus morphology, abnormal
Day 4 pronephric glomerulus unfused from pronephric glomerulus, abnormal
Day 4 pronephros development process quality, abnormal
pals1am520/m520 standard conditions Day 4 dorsal aorta dilated, abnormal
Day 4 pronephric glomerulus hypoplastic, abnormal
Day 4 pronephric glomerulus lacks all parts of type pronephric glomerular capillary, abnormal
Day 4 pronephric glomerulus morphology, abnormal
Day 4 pronephric glomerulus unfused from pronephric glomerulus, abnormal
Day 4 pronephros development process quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental dynamics : an official publication of the American Association of Anatomists for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dev. Dyn.