FIGURE

Fig. 4

ID

ZDB-FIG-110718-15

Publication

Becker et al., 2011 - Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish

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Fig. 4

Distinct alterations in Ca²⁺ handling induced by altered TNNT2 splicing. Diastolic (A) and transient amplitude (B) Ca²⁺ measurements in specific heart regions in controls, TNNT2sp morphants and TNNTatg (null) morphants. (C) CTD50 measured in atrium, atrioventricular canal (AVC), outer ventricular curvature (OC), mid-ventricle (MV) and inner ventricular curvature (IC). Asterisk donates P<0.05 for comparison of TNNT2sp morphant with control sample, or TNNT2atg morphant with control. All data expressed as mean ± s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-tnnt2a WT + MO3-tnnt2a
Knockdown Reagents:	MO1-tnnt2a MO3-tnnt2a
Observed In:	cardiac muscle cell regulation of cardiac muscle contraction by calcium ion signaling
Stage:	Day 4

Phenotype Detail

Acknowledgments

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