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ZIRC
ZFIN ID: ZDB-FIG-110718-15
Becker et al., 2011 - Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Disease models & mechanisms   4(3):400-410 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Day 4

Fig. 4

Distinct alterations in Ca2+ handling induced by altered TNNT2 splicing. Diastolic (A) and transient amplitude (B) Ca2+ measurements in specific heart regions in controls, TNNT2sp morphants and TNNTatg (null) morphants. (C) CTD50 measured in atrium, atrioventricular canal (AVC), outer ventricular curvature (OC), mid-ventricle (MV) and inner ventricular curvature (IC). Asterisk donates P<0.05 for comparison of TNNT2sp morphant with control sample, or TNNT2atg morphant with control. All data expressed as mean ± s.e.m.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-tnnt2a standard conditions Day 4 cardiac muscle cell electric potential, abnormal
Day 4 regulation of cardiac muscle contraction by calcium ion signaling disrupted, abnormal
WT + MO3-tnnt2a standard conditions Day 4 cardiac muscle cell electric potential, abnormal
Day 4 regulation of cardiac muscle contraction by calcium ion signaling disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.