ZFIN ID: ZDB-PERS-960805-635
Zon, Leonard I.
Email: zon@enders.tch.harvard.edu
URL: http://zon.tchlab.org
Affiliation: The Zon Lab
Address: Howard Hughes Medical Institute Children's Hospital Boston Division of Hematology/Oncology 300 Longwood Avenue, Karp 8 Boston, MA 02115 USA
Country: United States
Phone: (617) 919-2069
Fax: (617) 355-7262
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Bornhorst, D., Gheller, B., Zon, L.I. (2024) Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones. Methods in molecular biology (Clifton, N.J.). 2707:265277265-277
Song, J., Gooding, A.R., Hemphill, W.O., Love, B.D., Robertson, A., Yao, L., Zon, L.I., North, T.E., Kasinath, V., Cech, T.R. (2023) Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science (New York, N.Y.). 381:133113371331-1337
Oksuz, O., Henninger, J.E., Warneford-Thomson, R., Zheng, M.M., Erb, H., Vancura, A., Overholt, K.J., Hawken, S.W., Banani, S.F., Lauman, R., Reich, L.N., Robertson, A.L., Hannett, N.M., Lee, T.I., Zon, L.I., Bonasio, R., Young, R.A. (2023) Transcription factors interact with RNA to regulate genes. Molecular Cell. 83(14):2449-2463.e13
Binder, V., Li, W., Faisal, M., Oyman, K., Calkins, D.L., Shaffer, J., Teets, E.M., Sher, S., Magnotte, A., Belardo, A., Deruelle, W., Gregory, T.C., Orwick, S., Hagedorn, E.J., Perlin, J.R., Avagyan, S., Lichtig, A., Barrett, F., Ammerman, M., Yang, S., Zhou, Y., Carson, W.E., Shive, H.R., Blachly, J.S., Lapalombella, R., Zon, L.I., Blaser, B.W. (2023) Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Reports. 42:112528112528
Hagedorn, E.J., Perlin, J.R., Freeman, R.J., Wattrus, S.J., Han, T., Mao, C., Kim, J.W., Fernández-Maestre, I., Daily, M.L., D'Amato, C., Fairchild, M.J., Riquelme, R., Li, B., Ragoonanan, D.A.V.E., Enkhbayar, K., Henault, E.L., Wang, H.G., Redfield, S.E., Collins, S.H., Lichtig, A., Yang, S., Zhou, Y., Kunar, B., Gomez-Salinero, J.M., Dinh, T.T., Pan, J., Holler, K., Feldman, H.A., Butcher, E.C., van Oudenaarden, A., Rafii, S., Junker, J.P., Zon, L.I. (2023) Transcription factor induction of vascular blood stem cell niches in vivo. Developmental Cell. 58(12):1037-1051.e4
Insco, M.L., Abraham, B.J., Dubbury, S.J., Kaltheuner, I.H., Dust, S., Wu, C., Chen, K.Y., Liu, D., Bellaousov, S., Cox, A.M., Martin, B.J.E., Zhang, T., Ludwig, C.G., Fabo, T., Modhurima, R., Esgdaille, D.E., Henriques, T., Brown, K.M., Chanock, S.J., Geyer, M., Adelman, K., Sharp, P.A., Young, R.A., Boutz, P.L., Zon, L.I. (2023) Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.). 380:eabn7625eabn7625
Tavakoli, S., Garcia, V., Gähwiler, E., Adatto, I., Rangan, A., Messemer, K.A., Kakhki, S.A., Yang, S., Chan, V.S., Manning, M.E., Fotowat, H., Zhou, Y., Wagers, A.J., Zon, L.I. (2023) Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species. Cell Reports. 42:112365112365
LeBleu, V.S., Dai, J., Tsutakawa, S., MacDonald, B.A., Alge, J.L., Sund, M., Xie, L., Sugimoto, H., Tainer, J., Zon, L.I., Kalluri, R. (2023) Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(7):1046-1060
Adatto, I., Lawrence, C., Krug, L., Zon, L.I. (2022) The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio). PLoS One. 17:e0278302e0278302
Ablain, J., Al Mahi, A., Rothschild, H., Prasad, M., Aires, S., Yang, S., Dokukin, M.E., Xu, S., Dang, M., Sokolov, I., Lian, C.G., Zon, L.I. (2022) Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nature Genetics. 54(12):1839-1852
Wattrus, S.J., Smith, M.L., Rodrigues, C.P., Hagedorn, E.J., Kim, J.W., Budnik, B., Zon, L.I. (2022) Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science (New York, N.Y.). 377:1413-1419
Rubin, S.A., Baron, C.S., Pessoa Rodrigues, C., Duran, M., Corbin, A.F., Yang, S.P., Trapnell, C., Zon, L.I. (2022) Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish. The Journal of experimental medicine. 219(9)
Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
García-Castillo, J., Alcaraz-Pérez, F., Martínez-Balsalobre, E., García-Moreno, D., Rossmann, M.P., Fernández-Lajarín, M., Bernabé-García, M., Pérez-Oliva, A.B., Rodríguez-Cortez, V.C., Bueno, C., Adatto, I., Agarwal, S., Menéndez, P., Zon, L.I., Mulero, V., Cayuela, M.L. (2021) Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 118(32):
He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729
Avagyan, S., Weber, M.C., Ma, S., Prasad, M., Mannherz, W.P., Yang, S., Buenrostro, J.D., Zon, L.I. (2021) Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood advances. 5:2673-2686
Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
Khajavi, M., Zhou, Y., Schiffer, A.J., Bazinet, L., Birsner, A.E., Zon, L., D'Amato, R.J. (2021) Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21404
Ablain, J., Liu, S., Moriceau, G., Lo, R.S., Zon, L.I. (2021) SPRED1 deletion confers resistance to MAPK inhibition in melanoma. The Journal of experimental medicine. 218(3):
Patton, E.E., Mueller, K.L., Adams, D.J., Anandasabapathy, N., Aplin, A.E., Bertolotto, C., Bosenberg, M., Ceol, C.J., Chi, P., Herlyn, M., Holmen, S.L., Karreth, F.A., Kaufman, C.K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D.B., Lund, A.W., Marie, K.L., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, C.D., Ronai, Z.A., Samuels, Y., Soengas, M.S., Villanueva, J., Weeraratna, A.T., White, R.M., Yeh, I., Zhu, J., Zon, L.I., Hurlbert, M.S., Merlino, G. (2021) Melanoma models for the next generation of therapies. Cancer Cell. 39(5):610-631
Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
Wattrus, S.J., Zon, L.I. (2021) Blood in the water: recent uses of zebrafish to study myeloid biology. Current opinion in hematology. 28:43-49
Minnoye, L., Taskiran, I.I., Mauduit, D., Fazio, M., Van Aerschot, L., Hulselmans, G., Christiaens, V., Makhzami, S., Seltenhammer, M., Karras, P., Primot, A., Cadieu, E., van Rooijen, E., Marine, J.C., Egidy, G., Ghanem, G.E., Zon, L., Wouters, J., Aerts, S. (2020) Cross-species analysis of enhancer logic using deep learning. Genome research. 30:1815-1834
Taylor, A.M., Macari, E.R., Chan, I.T., Blair, M.C., Doulatov, S., Vo, L.T., Raiser, D.M., Siva, K., Basak, A., Pirouz, M., Shah, A.N., McGrath, K., Humphries, J.M., Stillman, E., Alter, B.P., Calo, E., Gregory, R.I., Sankaran, V.G., Flygare, J., Ebert, B.L., Zhou, Y., Daley, G.Q., Zon, L.I. (2020) Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine. 12(566):
Fazio, M., van Rooijen, E., Mito, J.K., Modhurima, R., Weiskopf, E., Yang, S., Zon, L.I. (2020) Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis. Pigment cell & melanoma research. 34(3):641-647
Hsu, J., Huang, H.T., Lee, C.T., Choudhuri, A., Wilson, N.K., Abraham, B.J., Moignard, V., Kucinski, I., Yu, S., Hyde, R.K., Tober, J., Cai, X., Li, Y., Guo, Y., Yang, S., Superdock, M., Trompouki, E., Calero-Nieto, F.J., Ghamari, A., Jiang, J., Gao, P., Gao, L., Nguyen, V., Robertson, A.L., Durand, E.M., Kathrein, K.L., Aifantis, I., Gerber, S.A., Tong, W., Tan, K., Cantor, A.B., Zhou, Y., Liu, P.P., Young, R.A., Göttgens, B., Speck, N.A., Zon, L.I. (2020) CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. 117(38):23626-23635
Wattrus, S.J., Zon, L.I. (2020) A Transgenic System for Rapid Magnetic Enrichment of Rare Embryonic Cells. Zebrafish. 17(5):354-357
Johansson, J.A., Marie, K.L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A.P., Dreger, M., Houston, D.R., Dooley, C.M., Sims, A.H., Busch-Nentwich, E.M., Zon, L.I., Illingworth, R.S., Patton, E.E. (2020) PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Developmental Cell. 54(3):317-332.e9
Makarova, N., Kalaparthi, V., Wang, A., Williams, C., Dokukin, M.E., Kaufman, C.K., Zon, L., Sokolov, I. (2020) Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. Journal of the Mechanical Behavior of Biomedical Materials. 107:103746
Harris, J.M., Wang, A.Y., Boulanger-Weill, J., Santoriello, C., Foianini, S., Lichtman, J.W., Zon, L.I., Arlotta, P. (2020) Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Developmental Cell. 53:577-588.e7
Choi, J., Zhang, T., Vu, A., Ablain, J., Makowski, M.M., Colli, L.M., Xu, M., Hennessey, R.C., Yin, J., Rothschild, H., Gräwe, C., Kovacs, M.A., Funderburk, K.M., Brossard, M., Taylor, J., Pasaniuc, B., Chari, R., Chanock, S.J., Hoggart, C.J., Demenais, F., Barrett, J.H., Law, M.H., Iles, M.M., Yu, K., Vermeulen, M., Zon, L.I., Brown, K.M. (2020) Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nature communications. 11:2718
Fazio, M., Ablain, J., Chuan, Y., Langenau, D.M., Zon, L.I. (2020) Zebrafish patient avatars in cancer biology and precision cancer therapy. Nature reviews. Cancer. 20(5):263-273
Santoriello, C., Sporrij, A., Yang, S., Flynn, R.A., Henriques, T., Dorjsuren, B., Custo Greig, E., McCall, W., Stanhope, M.E., Fazio, M., Superdock, M., Lichtig, A., Adatto, I., Abraham, B.J., Kalocsay, M., Jurynec, M., Zhou, Y., Adelman, K., Calo, E., Zon, L.I. (2020) RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nature cell biology. 22(4):372-379
Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
Cassar, S., Adatto, I., Freeman, J.L., Gamse, J.T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R., Van Cruchten, S., Zon, L. (2019) Use of Zebrafish in Drug Discovery Toxicology. Chemical Research in Toxicology. 33(1):95-118
Gómez-Abenza, E., Ibáñez-Molero, S., García-Moreno, D., Fuentes, I., Zon, L.I., Mione, M.C., Cayuela, M.L., Gabellini, C., Mulero, V. (2019) Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. Journal of experimental & clinical cancer research : CR. 38:405
Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2019) Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 573:E1
Tyrkalska, S.D., Pérez-Oliva, A.B., Rodríguez-Ruiz, L., Martínez-Morcillo, F.J., Alcaraz-Pérez, F., Martínez-Navarro, F.J., Lachaud, C., Ahmed, N., Schroeder, T., Pardo-Sánchez, I., Candel, S., López-Muñoz, A., Choudhuri, A., Rossmann, M.P., Zon, L.I., Cayuela, M.L., García-Moreno, D., Mulero, V. (2019) Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 51(1):50-63.e5
Cagan, R.L., Zon, L.I., White, R.M. (2019) Modeling Cancer with Flies and Fish. Developmental Cell. 49:317-324
Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J.D., Wang, R., Xiong, F., Meng, S., Clements, T.P., Tandon, B., Wagner, D.S., Diaz, M.F., Wenzel, P.L., Miller, Y.I., Traver, D., Cooke, J.P., Li, W., Zon, L.I., Chen, K., Bai, Y., Fang, L. (2019) AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science (New York, N.Y.). 363:1085-1088
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Rost, M.S., Shestopalov, I., Liu, Y., Vo, A.H., Richter, C.E., Emly, S.M., Barrett, F.G., Stachura, D.L., Holinstat, M., Zon, L.I., Shavit, J.A. (2018) Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood advances. 2:3418-3427
Wattrus, S.J., Zon, L.I. (2018) Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish. Blood advances. 2:3063-3069
Ablain, J., Xu, M., Rothschild, H., Jordan, R.C., Mito, J.K., Daniels, B.H., Bell, C.F., Joseph, N.M., Wu, H., Bastian, B.C., Zon, L.I., Yeh, I. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.. Science (New York, N.Y.). 362(6418):1055-1060
Yien, Y.Y., Shi, J., Chen, C., Cheung, J.T., Grillo, A.S., Shrestha, R., Li, L., Zhang, X., Kafina, M.D., Kingsley, P.D., King, M.J., Ablain, J., Li, H., Zon, L., Palis, J., Burke, M.D., Bauer, D.E., Orkin, S.H., Koehler, C.M., Phillips, J.D., Kaplan, J., Ward, D.M., Lodish, H.F., Paw, B.H. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of biological chemistry. 293(51):19797-19811
Parada-Kusz, M., Penaranda, C., Hagedorn, E.J., Clatworthy, A., Nair, A.V., Henninger, J.E., Ernst, C., Li, B., Riquelme, R., Jijon, H., Villablanca, E.J., Zon, L.I., Hung, D., Allende, M.L. (2018) Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease models & mechanisms. 11(11):
Mandelbaum, J., Shestopalov, I.A., Henderson, R.E., Chau, N.G., Knoechel, B., Wick, M.J., Zon, L.I. (2018) Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.. The Journal of experimental medicine. 215(10):2673-2685
Lahvic, J.L., Ammerman, M., Li, P., Blair, M.C., Stillman, E.R., Fast, E.M., Robertson, A.L., Christodoulou, C., Perlin, J.R., Yang, S., Chiang, N., Norris, P.C., Daily, M.L., Redfield, S.E., Chan, I.T., Chatrizeh, M., Chase, M.E., Weis, O., Zhou, Y., Serhan, C.N., Zon, L.I. (2018) Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proceedings of the National Academy of Sciences of the United States of America. 115(37):9252-9257
Mansour, M.R., He, S., Li, Z., Lobbardi, R., Abraham, B.J., Hug, C., Rahman, S., Leon, T.E., Kuang, Y.Y., Zimmerman, M.W., Blonquist, T., Gjini, E., Gutierrez, A., Tang, Q., Garcia-Perez, L., Pike-Overzet, K., Anders, L., Berezovskaya, A., Zhou, Y., Zon, L.I., Neuberg, D., Fielding, A.K., Staal, F.J.T., Langenau, D.M., Sanda, T., Young, R.A., Look, A.T. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 215(7):1929-1945
Kapp, F.G., Perlin, J.R., Hagedorn, E.J., Gansner, J.M., Schwarz, D.E., O'Connell, L.A., Johnson, N.S., Amemiya, C., Fisher, D.E., Wölfle, U., Trompouki, E., Niemeyer, C.M., Driever, W., Zon, L.I. (2018) Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 558(7710):445-448
McConnell, A.M., Mito, J.K., Ablain, J., Dang, M., Formichella, L., Fisher, D.E., Zon, L.I. (2018) Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Developmental Biology. 449(2):107-114
Bennett, A.H., O'Donohue, M.F., Gundry, S.R., Chan, A.T., Widrick, J., Draper, I., Chakraborty, A., Zhou, Y., Zon, L.I., Gleizes, P.E., Beggs, A.H., Gupta, V.A. (2018) RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genetics. 14:e1007226
Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M.S., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dörken, B., Speck, C., Mallette, F.A., Zon, L.I., Holmen, S.L., Peeper, D.S., Samuels, Y., Schmitt, C.A., Lee, S. (2018) Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 33:322-336.e8
Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
Kulkeaw, K., Inoue, T., Ishitani, T., Nakanishi, Y., Zon, L.I., Sugiyama, D. (2017) Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. British journal of haematology. 180(3):420-431
Norris, M.L., Pauli, A., Gagnon, J.A., Lord, N.D., Rogers, K.W., Mosimann, C., Zon, L.I., Schier, A.F. (2017) Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. eLIFE. 6
Neiswender, J.V., Kortum, R.L., Bourque, C., Kasheta, M., Zon, L., Morrison, D.K., Ceol, C.J. (2017) KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.. Cancer research. 77(21):5820-5830
Crawford, N.G., Kelly, D.E., Hansen, M.E.B., Beltrame, M.H., Fan, S., Bowman, S.L., Jewett, E., Ranciaro, A., Thompson, S., Lo, Y., Pfeifer, S.P., Jensen, J.D., Campbell, M.C., Beggs, W., Hormozdiari, F., Mpoloka, S.W., Mokone, G.G., Nyambo, T., Wolde Meskel, D., Belay, G., Haut, J., Rothschild, H., Zon, L., Zhou, Y., Kovacs, M.A., Xu, M., Zhang, T., Bishop, K., Sinclair, J., Rivas, C., Elliot, E., Choi, J., Li, S.A., Hicks, B., Burgess, S., Abnet, C., Watkins-Chow, D.E., Oceana, E., Song, Y.S., Eskin, E., Brown, K.M., Marks, M.S., Loftus, S.K., Pavan, W.J., Yeager, M., Chanock, S., Tishkoff, S. (2017) Loci associated with skin pigmentation identified in African populations. Science (New York, N.Y.). 358(6365)
Perlin, J.R., Robertson, A.L., Zon, L.I. (2017) Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. The Journal of experimental medicine. 214(10):2817-2827
Ciarlo, C., Kaufman, C.K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T.M., Zhou, Y., Liao, E., Zon, L.I. (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. eLIFE. 6
Fazio, M., Avagyan, S., van Rooijen, E., Mannherz, W., Kaufman, C.K., Lobbardi, R., Langenau, D.M., Zon, L.I. (2017) Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors. Zebrafish. 14(4):379-382
van Rooijen, E., Fazio, M., Zon, L.I. (2017) From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics. Pigment cell & melanoma research. 30(4):402-412
Khajavi, M., Zhou, Y., Birsner, A.E., Bazinet, L., Di Sant, A.R., Schiffer, A.J., Rogers, M.S., Krishnaji, S.T., Hu, B., Nguyen, V., Zon, L., D'Amato, R.J. (2017) Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice. PLoS Genetics. 13:e1006848
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