ZFIN ID: ZDB-PUB-100112-10
Zebrafish tumor assays: the state of transplantation
Taylor, A.M., and Zon, L.I.
Date: 2009
Source: Zebrafish 6(4): 339-346 (Review)
Registered Authors: Taylor, Alison, Zon, Leonard I.
Keywords: none
MeSH Terms: Animals; Cell Biology; Cytological Techniques*; Disease Models, Animal; Humans (all 11) expand
PubMed: 20047467 Full text @ Zebrafish
ABSTRACT
Tumor transplant studies are important tools for studying cancer biology in a model organism. Transplantation is especially important for assaying tumor cell malignancy and migration capabilities, and is critical for identifying putative cancer stem cell populations. In this review, we discuss the current state of tumor transplantation studies performed in the zebrafish. We address several zebrafish-specific considerations for development of the transplant assay, including choosing recipient animals, transplant methods, and post-transplant observation. We also examine how the zebrafish is an advantageous model for transplantation, particularly with development of the translucent fish. Transplantation has already been critical for characterizing zebrafish models of leukemia, rhabdomyosarcoma, and melanoma. With further development of imaging techniques and other tools, zebrafish tumor transplantation will continue to contribute to our understanding of tumor cell biology.
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