PUBLICATION
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
- Authors
- Zon, L.I.,
- ID
- ZDB-PUB-131120-1
- Date
- 2008
- Source
- Nature 453: 306-313 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Signal Transduction/drug effects
- Hematopoietic Stem Cells/cytology*
- Hematopoietic Stem Cells/metabolism
- Regeneration/drug effects
- Regeneration/physiology*
- Animals
- Homeostasis/drug effects
- Homeodomain Proteins/genetics
- Homeodomain Proteins/metabolism
- Epigenesis, Genetic
- Humans
- PubMed
- 18480811 Full text @ Nature
Citation
Zon, L.I., (2008) Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature. 453:306-313.
Abstract
When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping