Tan, J.L., and Zon, L.I. (2011) Chemical screening in zebrafish for novel biological and therapeutic discovery. Meth. Cell. Biol.. 105:491-516.
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost-effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.