ZFIN ID: ZDB-PUB-000309-30
Zebrafish: a genetic approach in studying hematopoiesis
Paw, B.H. and Zon, L.I.
Date: 2000
Source: Current opinion in hematology 7(2): 79-84 (Journal)
Registered Authors: Paw, Barry, Zon, Leonard I.
Keywords: none
MeSH Terms: Animals; Disease Models, Animal; Hematopoiesis/genetics; Hematopoiesis/physiology; Mutation (all 7) expand
PubMed: 10698293 Full text @ Curr. Opin. Hematol.
ABSTRACT
The zebrafish (Danio rerio) has emerged in recent years as an exciting animal model system for studying vertebrate organ development and, in particular, the development of the hematopoietic system. The combined advantages of developmental biology and genetic screens for mutations in zebrafish have provided insights into early events in hematopoiesis and identified several genes required for normal blood development in vertebrates. As a result of the large-scale mutagenesis screens for developmental mutants, several zebrafish mutants with defects in blood development have been recovered. This review discusses how these blood mutations in zebrafish have given new perspectives on hematopoietic development.
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