PUBLICATION
Fishing for lymphoid genes
- Authors
- Trede, N.S., Zapata, A., and Zon, L.I.
- ID
- ZDB-PUB-010601-4
- Date
- 2001
- Source
- Trends in immunology 22(6): 302-307 (Journal)
- Registered Authors
- Trede, Nick, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Thymus Gland/physiology
- Animals
- Zebrafish/genetics*
- Zebrafish/immunology
- Phenotype
- Lymphoid Tissue/immunology*
- Genome
- Hematopoiesis/genetics*
- Mutation
- PubMed
- 11377288 Full text @ Trends Immunol.
Citation
Trede, N.S., Zapata, A., and Zon, L.I. (2001) Fishing for lymphoid genes. Trends in immunology. 22(6):302-307.
Abstract
Thymic organogenesis and T-cell lymphopoiesis are crucial interdependent processes that establish a functional vertebrate immune system. The current understanding of vertebrate thymic development during embryogenesis remains incomplete and would benefit from novel approaches. The zebrafish Danio rerio is a powerful developmental and genetic system for the dissection of early events in the ontogeny of the immune system. Forward genetic screens have uncovered genes involved in hematopoiesis, and specific screens are being designed to examine the genes that regulate T-cell development and the origin of the thymus. Studies of the zebrafish should improve our understanding of lymphoid development in vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping