ZFIN ID: ZDB-PUB-000621-2
Zebrafish: a model system for the study of human disease
Dooley, K. and Zon, L.I.
Date: 2000
Source: Current opinion in genetics & development 10(3): 252-256 (Review)
Registered Authors: Dooley, Kim, Zon, Leonard I.
Keywords: none
MeSH Terms: Animals; Genetic Diseases, Inborn/genetics*; Genetics, Medical*; Humans; Models, Genetic* (all 6) expand
PubMed: 10826982 Full text @ Curr. Opin. Genet. Dev.
ABSTRACT
The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology, being well suited to both developmental and genetic analysis. Large-scale genetic screens have identified hundreds of mutant phenotypes, many of which resemble human clinical disorders. The creation of critical genetic reagents, coupled with the rapid progress of the zebrafish genome initiative directed by the National Institutes of Health, are bringing this model system to its full potential for the study of vertebrate biology, physiology and human disease.
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