PUBLICATION

SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish

Authors
Liao, E.C., Paw, B.H., Oates, A.C., Pratt, S.J., Postlethwait, J.H., and Zon, L.I.
ID
ZDB-PUB-980415-5
Date
1998
Source
Genes & Development   12: 621-626 (Journal)
Registered Authors
Liao, Eric, Oates, Andrew, Paw, Barry, Postlethwait, John H., Pratt, Stephen J., Zon, Leonard I.
Keywords
clo; zebrafish; hematopoiesis; vasculogenesis
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Chromosome Mapping
  • Conserved Sequence
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/metabolism
  • Embryo, Nonmammalian
  • Endothelium, Vascular/embryology*
  • Gene Expression Regulation, Developmental
  • Hematopoietic Stem Cells/physiology*
  • Molecular Sequence Data
  • Mutation
  • Proto-Oncogene Proteins*
  • Transcription Factors*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins*
PubMed
9499398 Full text @ Genes & Dev.
Abstract
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that clo fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the clo mutation is not linked to the SCL locus. Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes