PUBLICATION
Melanocytes in Development, Regeneration, and Cancer
- Authors
- White, R.M., and Zon, L.I.
- ID
- ZDB-PUB-080915-22
- Date
- 2008
- Source
- Cell Stem Cell 3(3): 242-252 (Review)
- Registered Authors
- White, Richard M., Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Melanocytes/cytology
- Melanocytes/physiology*
- Melanoma/physiopathology*
- Humans
- Regeneration*
- Stem Cells/cytology
- Stem Cells/physiology
- PubMed
- 18786412 Full text @ Cell Stem Cell
Citation
White, R.M., and Zon, L.I. (2008) Melanocytes in Development, Regeneration, and Cancer. Cell Stem Cell. 3(3):242-252.
Abstract
The genes required for stem cell specification and lineage restriction during embryogenesis also play fundamental roles in adult tissue regeneration and cancer. This "development-regeneration-cancer" axis is exemplified by the vertebrate pigmentation system. Melanocytes exhibit almost unlimited self-renewal capacity during regenerative processes such as mammalian hair recoloration and zebrafish fin regeneration. Melanoma utilizes many regulatory signals and pathways required during ontogeny and regeneration. A discussion of these interconnections highlights how studies of stem cell function in embryonic and regenerative contexts can yield insights into melanoma biology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping