|ZFIN ID: ZDB-PUB-080915-22|
Melanocytes in Development, Regeneration, and Cancer
White, R.M., and Zon, L.I.
|Source:||Cell Stem Cell 3(3): 242-252 (Review)|
|Registered Authors:||White, Richard M., Zon, Leonard I.|
|PubMed:||18786412 Full text @ Cell Stem Cell|
White, R.M., and Zon, L.I. (2008) Melanocytes in Development, Regeneration, and Cancer. Cell Stem Cell. 3(3):242-252.
ABSTRACTThe genes required for stem cell specification and lineage restriction during embryogenesis also play fundamental roles in adult tissue regeneration and cancer. This "development-regeneration-cancer" axis is exemplified by the vertebrate pigmentation system. Melanocytes exhibit almost unlimited self-renewal capacity during regenerative processes such as mammalian hair recoloration and zebrafish fin regeneration. Melanoma utilizes many regulatory signals and pathways required during ontogeny and regeneration. A discussion of these interconnections highlights how studies of stem cell function in embryonic and regenerative contexts can yield insights into melanoma biology.
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