ZFIN ID: ZDB-PUB-170608-1
Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration
Choudhuri, A., Fast, E.M., Zon, L.I.
Date: 2017
Source: Stem Cell Reports 8: 1465-1471 (Other)
Registered Authors: Zon, Leonard I.
Keywords: HSC, chemical screen, clonality, niche, zebrafish
MeSH Terms:
  • Animals
  • Cell Differentiation
  • Cell Movement
  • Cell Self Renewal/physiology*
  • Hematopoietic Stem Cells/cytology*
  • Hematopoietic Stem Cells/metabolism
  • Platelet Membrane Glycoprotein IIb/metabolism
  • Proto-Oncogene Proteins c-myb/metabolism
  • Regeneration/physiology
  • Signal Transduction
  • Stem Cell Niche/physiology
  • Zebrafish
PubMed: 28591648 Full text @ Stem Cell Reports
ABSTRACT
This perspective describes the usefulness of zebrafish as a model to study interaction of hematopoietic stem cells with the associated niche in vivo, explains how such interactions influence regeneration, migration, and clonality of HSCs, and defines their fate during differentiation.
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