Jagannathan-Bogdan, M., and Zon, L.I. (2013) Hematopoiesis. Development (Cambridge, England). 140(12):2463-2467.
Hematopoiesis – the process by which blood cells are formed – has been studied intensely for over a century using a variety
of model systems. There is conservation of the overall hematopoietic process between vertebrates, although some differences
do exist. Over the last decade, the zebrafish has come to the forefront as a new model in hematopoiesis research, as it allows
the use of large-scale genetics, chemical screens and transgenics. This comparative approach to understanding hematopoiesis
has led to fundamental knowledge about the process and to the development of new therapies for disease. Here, we provide a
broad overview of vertebrate hematopoiesis. We also highlight the benefits of using zebrafish as a model.