ZFIN ID: ZDB-PUB-100223-47
Swimming into the future of drug discovery: in vivo chemical screens in zebrafish
Bowman, T.V., and Zon, L.I.
Date: 2010
Source: ACS Chemical Biology 5(2): 159-161 (Review)
Registered Authors: Bowman, Teresa, Zon, Leonard I.
Keywords: none
MeSH Terms: Animals; Drug Discovery/methods*; Drug Evaluation, Preclinical/methods; Small Molecule Libraries*; Zebrafish/metabolism*
PubMed: 20166761 Full text @ ACS Chem. Biol.
ABSTRACT
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.
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