PUBLICATION
Swimming into the future of drug discovery: in vivo chemical screens in zebrafish
- Authors
- Bowman, T.V., and Zon, L.I.
- ID
- ZDB-PUB-100223-47
- Date
- 2010
- Source
- ACS Chemical Biology 5(2): 159-161 (Review)
- Registered Authors
- Bowman, Teresa, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Drug Discovery/methods*
- Drug Evaluation, Preclinical/methods
- Small Molecule Libraries*
- Zebrafish/metabolism*
- PubMed
- 20166761 Full text @ ACS Chem. Biol.
Citation
Bowman, T.V., and Zon, L.I. (2010) Swimming into the future of drug discovery: in vivo chemical screens in zebrafish. ACS Chemical Biology. 5(2):159-161.
Abstract
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping