|ZFIN ID: ZDB-PUB-100223-47|
Swimming into the future of drug discovery: in vivo chemical screens in zebrafish
Bowman, T.V., and Zon, L.I.
|Source:||ACS Chemical Biology 5(2): 159-161 (Review)|
|Registered Authors:||Bowman, Teresa, Zon, Leonard I.|
|PubMed:||20166761 Full text @ ACS Chem. Biol.|
Bowman, T.V., and Zon, L.I. (2010) Swimming into the future of drug discovery: in vivo chemical screens in zebrafish. ACS Chemical Biology. 5(2):159-161.
ABSTRACTIn recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.
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