ZFIN ID: ZDB-PUB-120718-25
Cancer and inflammation: an aspirin a day keeps the cancer at bay
Mione, M., and Zon, L.I.
Date: 2012
Source: Current biology : CB 22(13): R522-525 (Review)
Registered Authors: Mione, Marina, Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Cell Transformation, Neoplastic/metabolism*
  • Dinoprostone/metabolism*
  • Leukocytes/metabolism*
  • Zebrafish/genetics*
PubMed: 22789999 Full text @ Curr. Biol.

Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE2 promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE2 production and could be used with other anti-tumor agents in the treatment of cancer.