Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis
- Davidson, A.J. and Zon, L.I.
- Current topics in developmental biology 50: 45-60 (Chapter)
- Registered Authors
- Davidson, Alan, Zon, Leonard I.
- MeSH Terms
- Body Patterning/physiology
- Embryonic Induction/physiology
- Genes, Homeobox
- Hematopoietic Stem Cells/physiology*
- 10948449 Full text @ Curr. Top. Dev. Biol.
Davidson, A.J. and Zon, L.I. (2000) Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis. Current topics in developmental biology. 50:45-60.
The formation of hematopoietic stem cells during development occurs by a multistep process that begins with the induction of ventral mesoderm. This mesoderm is patterned during gastrulation by a bone morphogenetic protein (BMP) signaling pathway that is mediated, at least in part, by members of the Mix and Vent families of homeobox transcription factors. Following gastrulation, a subset of ventral mesoderm is specified to become hematopoietic stem cells. Key determinants of hematopoietic fate include the product of the zebrafish cloche gene and the basic helix-loop-helix transcription factor SCL. Future studies in Xenopus and zebrafish should reveal other critical factors in this developmental pathway.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes