ZFIN ID: ZDB-PUB-070629-8
Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors
Goessling, W., North, T.E., and Zon, L.I.
Date: 2007
Source: Nature Methods 4(7): 551-553 (Journal)
Registered Authors: Goessling, Wolfram, North, Trista, Zon, Leonard I.
Keywords: none
MeSH Terms: Animals; Disease Models, Animal*; Liver Neoplasms, Experimental/pathology; Microscopy, Acoustic/methods*; Zebrafish*
PubMed: 17572681 Full text @ Nat. Methods
ABSTRACT
Zebrafish are a valuable vertebrate model to study carcinogenesis, but noninvasive imaging is challenging because adult fish are not transparent. Here we show that tumors could be readily detected in vivo using high-resolution microscopic ultrasound in zebrafish. We successfully obtained tissue perfusion calculations and cellular aspirates, and analyzed tumor progression and response to treatment. Ultrasound biomicroscopy allows longitudinal studies of tumor development and real-time assessment of therapeutic effects in zebrafish.
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