Publication	Data		Fish	Anatomy
Tessadori et al., 2021	Figure 1		tbx5am21/m21 ,   tbx5ahu6499/hu6499	atrioventricular canal bmp4 expression increased amount, abnormal atrioventricular canal has2 expression increased amount, abnormal atrioventricular canal tbx2b expression increased amount, abnormal atrioventricular canal vcana expression increased amount, abnormal atrium myh6 expression spatial pattern, abnormal atrium nppa expression decreased amount, abnormal cardiac ventricle myh6 expression spatial pattern, abnormal cardiac ventricle nppa expression decreased amount, abnormal heart looping decreased process quality, abnormal heart tube edematous, abnormal
	Figure 3		tbx5ahu6499/hu6499; hu10671Tg/hu10671Tg; hu6531Tg/hu6531Tg; nkuasrfp1aTg/nkuasrfp1aTg	cardiac chamber morphogenesis decreased process quality, abnormal
	Figure 4		tbx5ahu6499/hu6499; hu6531Tg/hu6531Tg; hu6851Tg/hu6851Tg	cardiac chamber morphogenesis decreased process quality, abnormal heart looping decreased process quality, abnormal
	Figure 7		tbx5ahu6499/hu6499; hu10671Tg/hu10671Tg; hu6531Tg/hu6531Tg; nkuasrfp1aTg/nkuasrfp1aTg	cardiac muscle cell circular, abnormal cardiac muscle cell regulation of cell motility decreased process quality, abnormal heart tissue morphogenesis decreased process quality, abnormal
	Figure 8		tbx5ahu6499/hu6499; hu10671Tg/hu10671Tg; hu6531Tg/hu6531Tg; nkuasrfp1aTg/nkuasrfp1aTg ,   tbx5ahu6499/hu6499; hu8889Tg/hu8889Tg	cardiac ventricle Citrine expression spatial pattern, abnormal heart looping decreased process quality, abnormal
Cunningham et al., 2020	Figure 1		WT + MO4-tbx5a ,   tbx5atpl148/tpl148 + MO4-tbx5a ,   tbx5atpl147/tpl147 + MO4-tbx5a	heart edematous, abnormal pectoral fin absent, abnormal pectoral fin malformed, abnormal
Boyle Anderson et al., 2018	Fig. 3		AB + MO2-tbx5a	primordial vasculature hhex expression decreased amount, abnormal primordial vasculature hhex expression spatial pattern, abnormal primordial vasculature sox7 expression spatial pattern, abnormal pronephros cox6b1 expression increased amount, abnormal pronephros anatomical region cox6b1 expression mislocalised, abnormal
	Fig. 4		AB + MO2-tbx5a	somite aimp1a expression decreased amount, abnormal somite hsp90aa1.2 expression increased amount, abnormal somite obsl1a expression increased amount, abnormal
	Fig. S4		AB + MO2-tbx5a	head mybphb expression increased amount, abnormal immature eye obsl1a expression absent, abnormal somite aimp1a expression decreased amount, abnormal somite hsp90aa1.2 expression increased amount, abnormal somite hspa8b expression increased amount, abnormal somite hspa8b expression increased distribution, abnormal somite mybphb expression increased amount, abnormal somite obsl1a expression increased amount, abnormal somite medial side ctsc expression increased distribution, abnormal whole organism anterior side phlda2 expression decreased amount, abnormal
	Fig. S5		AB + MO2-tbx5a	immature eye cryba1l1 expression decreased amount, abnormal immature eye tyrp1b expression increased amount, abnormal periderm si:dkey-204l11.1 expression decreased amount, abnormal yolk napbb expression mislocalised, abnormal
Grajevskaja et al., 2018	Fig. 2		tbx5atpl58Gt/+ ,   tbx5atpl58Gt/tpl58Gt	atrium increased size, abnormal cardiac ventricle morphology, abnormal heart edematous, abnormal heart looping arrested, abnormal pectoral fin absent, abnormal pectoral fin morphology, abnormal pectoral fin truncated, abnormal
Guzzolino et al., 2018	Fig. 6		tbx5azf2156/zf2156 ,   twu34Tg + MO1-tbx5a	heart s1pr1 expression increased amount, abnormal heart contraction decreased rate, abnormal heart looping decreased occurrence, abnormal heart morphology, abnormal heart straight, abnormal pectoral fin absent, abnormal pericardium edematous, abnormal
Ghosh et al., 2017	Fig. 4		WT + MO1-tbx5a	atrium morphology, abnormal atrium size, abnormal cardiac ventricle morphology, abnormal cardiac ventricle size, abnormal heart contraction decreased rate, abnormal heart looping process quality, abnormal heart morphology, abnormal pericardium edematous, abnormal
	Fig. 5		WT + CRISPR2-tbx5a	atrium morphology, abnormal atrium size, abnormal cardiac ventricle morphology, abnormal cardiac ventricle size, abnormal heart contraction decreased rate, abnormal heart looping process quality, abnormal heart morphology, abnormal pericardium edematous, abnormal
	Fig. 6		WT + MO1-tbx5a ,   WT + CRISPR2-tbx5a	paired fin bmp4 expression decreased amount, abnormal paired fin absent, abnormal paired fin decreased size, abnormal paired fin morphology, abnormal
D'Aurizio et al., 2016	Fig. 2		AB + MO1-tbx5a	whole organism atp1a2a expression increased amount, abnormal whole organism camk2d1 expression increased amount, abnormal whole organism hand2 expression increased amount, abnormal whole organism mef2aa expression increased amount, abnormal whole organism ndrg4 expression increased amount, abnormal whole organism robo1 expression increased amount, abnormal whole organism srfa expression increased amount, abnormal whole organism dre-mir-19a expression increased amount, abnormal whole organism dre-mir-7ba expression increased amount, abnormal whole organism mir10d expression increased amount, abnormal whole organism mir30a expression increased amount, abnormal whole organism mir34a expression increased amount, abnormal
Chiavacci et al., 2015	Fig. 2		twu34Tg + MO1-tbx5a	heart development disrupted, abnormal heart morphology, abnormal pectoral fin morphology, abnormal whole organism dead, abnormal
Li et al., 2014	Fig. 6		WT + MO1-tbx5a	heart morphology, abnormal pectoral fin morphology, abnormal somite U-shaped, abnormal
Pi-Roig et al., 2014	Fig. 1		WT + MO1-tbx5a	heart looping arrested, abnormal heart looping disrupted, abnormal heart malformed, abnormal
	Fig. 2		WT + MO1-tbx5a	heart jogging disrupted, abnormal
	Fig. 5		WT + MO1-tbx5a	pectoral fin aplastic, abnormal pectoral fin development disrupted, abnormal
Tong et al., 2014	Fig. 4		f1Tg + MO1-tbx5a	heart decreased size, abnormal
Parrie et al., 2013	Fig. 10		WT + MO4-tbx5a	heart development disrupted, abnormal heart structure, abnormal
	Fig. 11		WT + MO4-tbx5a	pectoral fin aplastic, abnormal pectoral fin development disrupted, abnormal
	Fig. 4		tbx5am21/m21; s883Tg	heart contraction decreased rate, abnormal heart development disrupted, abnormal heart looping disrupted, abnormal heart structure, abnormal
	Fig. 9		tbx5am21/m21	pectoral fin aplastic, abnormal pectoral fin development disrupted, abnormal
Chiavacci et al., 2012	Fig. S8		s849Tg; uto1Tg + MO1-tbx5a	fin agenesis, abnormal pericardium edematous, abnormal
Tsai et al., 2012	Fig. 1		WT + MO1-tbx5a	cardiac ventricle decreased contractility, abnormal heart edematous, abnormal heart morphology, abnormal pectoral fin aplastic, abnormal pectoral fin truncated, abnormal somite U-shaped, abnormal trunk bent, abnormal
	Fig. 2		WT + MO1-tbx5a	whole organism akt2 expression decreased amount, abnormal whole organism ghra expression decreased amount, abnormal whole organism ghrb expression decreased amount, abnormal whole organism igf1 expression decreased amount, abnormal
	Fig. 3		WT + MO1-tbx5a	apoptotic process increased occurrence, abnormal
	Fig. 4		WT + MO1-tbx5a	whole organism badb expression increased amount, abnormal whole organism bcl2a expression increased amount, abnormal
	Fig. 5		WT + MO1-tbx5a	whole organism cdk2 expression increased amount, abnormal whole organism cdkn1bb expression increased amount, abnormal
	Fig. 6		WT + MO1-tbx5a	atrium myh6 expression decreased amount, abnormal cardiac ventricle myh7 expression decreased amount, abnormal cardiac ventricle myl7 expression decreased amount, abnormal
Lu et al., 2011	Fig. 1		WT + MO1-tbx5a	apoptotic process increased occurrence, abnormal heart looping disrupted, abnormal heart malformed, abnormal pectoral fin hypoplastic, abnormal trunk curled, abnormal trunk decreased length, abnormal
	Fig. 7		WT + MO1-tbx5a	cardiac muscle cell bicellular tight junction dissociated from cardiac muscle cell bicellular tight junction, abnormal cardiac muscle cell mitochondrion increased amount, abnormal cardiac muscle cell mitochondrion swollen, abnormal myocardium disorganized, abnormal myocardium myofibril disorganized, abnormal
Camarata et al., 2010	Fig. 6		tbx5am21/m21	atrial ventricular junction remodeling disrupted, abnormal atrioventricular canal aplastic, abnormal
	Fig. 7		tbx5am21/+	atrioventricular valve formation disrupted, abnormal atrioventricular valve structure, abnormal
	Fig. 8		tbx5am21/m21	atrioventricular valve formation disrupted, abnormal atrioventricular valve structure, abnormal
	Fig. 9		tbx5am21/m21 ,   tbx5am21/+	atrial ventricular junction remodeling disrupted, abnormal atrioventricular canal aplastic, abnormal atrioventricular canal morphology, abnormal
Liu et al., 2010	Fig. 6		tbx5am21/m21	epicardium aplastic, abnormal heart looping delayed, abnormal
Ghosh et al., 2009	Fig. 6		WT + MO1-tbx5a	heart looping disrupted, abnormal pectoral fin aplastic, abnormal pericardium edematous, abnormal
Rothschild et al., 2009	Fig. 3		WT + MO2-tbx5a	heart edematous, abnormal heart looping arrested, abnormal pectoral fin aplastic, abnormal
	Fig. 7		WT + MO2-tbx5a ,   tbx5am21/m21	heart physical object quality, abnormal pectoral fin physical object quality, abnormal
Lu et al., 2008	Fig. 1		WT + MO1-tbx5a	heart looping disrupted, abnormal heart morphology, abnormal pericardium edematous, abnormal
	Fig. 2		WT + MO1-tbx5a	heart decreased size, abnormal heart looping disrupted, abnormal heart morphology, abnormal pericardium edematous, abnormal whole organism semi-lethal (sensu genetics), abnormal
	Fig. 5		WT + MO1-tbx5a	heart looping disrupted, abnormal heart morphology, abnormal
	text only		WT + MO4-tbx5a	heart looping disrupted, abnormal heart morphology, abnormal pericardium edematous, abnormal
Qu et al., 2008	Fig. 9		WT + MO1-tbx5a ,   tbx5am21/m21	heart development disrupted, abnormal heart morphology, abnormal
Phenotype Annotation (1994-2006)	Fig. for (m21)		tbx5am21/m21	heart quality, abnormal pectoral fin quality, abnormal
Fischer et al., 2003	Fig. 6		WT + MO1-tbx5a	pectoral fin bud absent, abnormal
Garrity et al., 2002	Fig. 1		tbx5am21/m21	heart looping arrested, abnormal heart tube linear, abnormal heart tube myocardium decreased thickness, abnormal heart tube present, abnormal pectoral fin absent, abnormal pericardium edematous, abnormal
	Fig. 2		tbx5am21/m21	mesenchyme pectoral fin cell population proliferation absent, abnormal mesenchyme pectoral fin flattened, abnormal pectoral fin absent, abnormal
	Fig. 4		WT + MO1-tbx5a	heart looping arrested, abnormal heart tube linear, abnormal pectoral fin absent, abnormal pectoral fin upturned, abnormal whole organism lacks parts or has fewer parts of type pectoral fin, abnormal
	Fig. 8		tbx5am21/m21	heart looping arrested, abnormal heart tube linear, abnormal heart tube present, abnormal presumptive cardiac ventricle heart tube decreased size, abnormal
	text only		tbx5am21/m21	blood circulation absent, abnormal heart contraction decreased frequency, abnormal whole organism dead, abnormal
Ng et al., 2002	Fig. 1		WT + MO3-tbx5a	pectoral fin aplastic, abnormal pectoral fin curved dorsal, abnormal pectoral fin decreased length, abnormal pectoral fin lepidotrichium decreased amount, abnormal pectoral girdle aplastic, abnormal
	Fig. 3		WT + MO3-tbx5a ,   tbx5am21/m21	pectoral fin bud aplastic, abnormal