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ZFIN ID: ZDB-FISH-150901-12774
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Fish name: WT + MO1-tbx5a
Genotype: WT
Targeting Reagent: MO1-tbx5a
HUMAN DISEASE MODELED by WT + MO1-tbx5a
Human Disease Conditions Citations
Holt-Oram syndrome standard conditions Garrity et al., 2002
GENE EXPRESSION
Gene expression in WT + MO1-tbx5a
RNA expression
Expressed Gene Structure Conditions Figures
akt2 standard conditions Fig. 2 with image from Tsai et al., 2012
badb chemical treatment by injection: growth hormone Fig. 4 with image from Tsai et al., 2012
standard conditions Fig. 4 with image from Tsai et al., 2012
Fig. 2 with image from Lu et al., 2011
baxa standard conditions Fig. 2 with image from Lu et al., 2011
bcl2a chemical treatment by injection: growth hormone Fig. 4 with image from Tsai et al., 2012
standard conditions Fig. 4 with image from Tsai et al., 2012
Fig. 2 with image from Lu et al., 2011
casp8 standard conditions Fig. 4 with image from Lu et al., 2011
cdk2 standard conditions Fig. 5 with image from Tsai et al., 2012
chemical treatment by injection: growth hormone Fig. 5 with image from Tsai et al., 2012
cdkn1bb standard conditions Fig. 5 with image from Tsai et al., 2012
chemical treatment by injection: growth hormone Fig. 5 with image from Tsai et al., 2012
efnb2a standard conditions Fig. 4 with image from Pi-Roig et al., 2014
ephb2a standard conditions Fig. 4 with image from Pi-Roig et al., 2014
fgf24 standard conditions Fig. 6 with image from Fischer et al., 2003
ghra standard conditions Fig. 2 with image from Tsai et al., 2012
ghrb standard conditions Fig. 2 with image from Tsai et al., 2012
hand2 standard conditions Fig. 6 from Lu et al., 2008
has2 standard conditions Fig. 4 from Tong et al., 2014
igf1 standard conditions Fig. 2 with image from Tsai et al., 2012
Fig. 6 from Lu et al., 2008
mstnb standard conditions Fig. 6 from Lu et al., 2008
myh6 chemical treatment by injection: growth hormone Fig. 6 with image from Tsai et al., 2012
standard conditions Fig. 6 with image from Tsai et al., 2012
Fig. 5,  Fig. 6 from Lu et al., 2008
myh7 chemical treatment by injection: growth hormone Fig. 6 with image from Tsai et al., 2012
standard conditions Fig. 6 with image from Tsai et al., 2012
Fig. 5,  Fig. 6 from Lu et al., 2008
myl7 chemical treatment by injection: growth hormone Fig. 6 with image from Tsai et al., 2012
standard conditions Fig. 2 with image from Pi-Roig et al., 2014
Fig. 6 with image from Tsai et al., 2012
Fig. 1 with image from Lou et al., 2011
Fig. 5,  Fig. 6 from Lu et al., 2008
myod1 standard conditions Fig. 6 from Lu et al., 2008
ndrg4 standard conditions Fig. 9 with image from Qu et al., 2008
nkx2.5 standard conditions Fig. 1 with image from Lou et al., 2011
Fig. 6 from Lu et al., 2008
prdm1a standard conditions Fig. 5 with image from Lee et al., 2006
sall1a standard conditions Fig. 4 with image from Harvey et al., 2006
sall4 standard conditions Fig. 2 with image from Harvey et al., 2006
tbx5a standard conditions Fig. 6 from Lu et al., 2008
Fig. 2 with image from Harvey et al., 2006
Reporter gene expression No data available
PHENOTYPE
Phenotype in WT + MO1-tbx5a
Phenotype Conditions Figures
apoptotic process increased occurrence, abnormal standard conditions Fig. 3 with image from Tsai et al., 2012
Fig. 1 with image from Lu et al., 2011
apoptotic process occurrence, ameliorated chemical treatment by injection: growth hormone Fig. 3 with image from Tsai et al., 2012
atrium myh6 expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 6 with image from Tsai et al., 2012
atrium myh6 expression decreased amount, abnormal standard conditions Fig. 6 with image from Tsai et al., 2012
atrium morphology, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
atrium size, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
cardiac muscle cell normal amount, normal standard conditions Fig. 1 with image from Lou et al., 2011
cardiac muscle cell bicellular tight junction dissociated from cardiac muscle cell bicellular tight junction, abnormal standard conditions Fig. 7 with image from Lu et al., 2011
cardiac muscle cell mitochondrion increased amount, abnormal standard conditions Fig. 7 with image from Lu et al., 2011
cardiac muscle cell mitochondrion swollen, abnormal standard conditions Fig. 7 with image from Lu et al., 2011
cardiac ventricle myh7 expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 6 with image from Tsai et al., 2012
cardiac ventricle myl7 expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 6 with image from Tsai et al., 2012
cardiac ventricle myh7 expression decreased amount, abnormal standard conditions Fig. 6 with image from Tsai et al., 2012
cardiac ventricle myl7 expression decreased amount, abnormal standard conditions Fig. 6 with image from Tsai et al., 2012
cardiac ventricle decreased contractility, abnormal standard conditions Fig. 1 with image from Tsai et al., 2012
cardiac ventricle morphology, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
cardiac ventricle size, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
heart decreased size, abnormal standard conditions Fig. 2 from Lu et al., 2008
heart edematous, abnormal standard conditions Fig. 1 with image from Tsai et al., 2012
heart malformed, abnormal standard conditions Fig. 1 with image from Pi-Roig et al., 2014
Fig. 1 with image from Lu et al., 2011
heart morphology, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
Fig. 6 from Li et al., 2014
Fig. 1 with image from Tsai et al., 2012
Fig. 1,  Fig. 2,  Fig. 5 from Lu et al., 2008
Fig. 9 with image from Qu et al., 2008
heart morphology, ameliorated chemical treatment by injection: growth hormone Fig. 6 from Li et al., 2014
heart morphology, normal standard conditions Fig. 1 with image from Lou et al., 2011
heart contraction decreased rate, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
heart development disrupted, abnormal standard conditions Fig. 9 with image from Qu et al., 2008
heart jogging disrupted, abnormal standard conditions Fig. 2 with image from Pi-Roig et al., 2014
heart looping arrested, abnormal standard conditions Fig. 1 with image from Pi-Roig et al., 2014
Fig. 4 with image from Garrity et al., 2002
heart looping disrupted, abnormal standard conditions Fig. 1 with image from Pi-Roig et al., 2014
Fig. 1 with image from Lu et al., 2011
Fig. 6 from Ghosh et al., 2009
Fig. 1,  Fig. 2,  Fig. 5 from Lu et al., 2008
heart looping process quality, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
heart morphogenesis process quality, normal standard conditions Fig. 1 with image from Lou et al., 2011
heart tube linear, abnormal standard conditions Fig. 4 with image from Garrity et al., 2002
myocardium disorganized, abnormal standard conditions Fig. 7 with image from Lu et al., 2011
myocardium myofibril disorganized, abnormal standard conditions Fig. 7 with image from Lu et al., 2011
paired fin absent, abnormal standard conditions Fig. 6 from Ghosh et al., 2017
paired fin decreased size, abnormal standard conditions Fig. 6 from Ghosh et al., 2017
paired fin morphology, abnormal standard conditions Fig. 6 from Ghosh et al., 2017
pectoral fin absent, abnormal standard conditions Fig. 4 with image from Garrity et al., 2002
pectoral fin aplastic, abnormal standard conditions Fig. 5 with image from Pi-Roig et al., 2014
Fig. 1 with image from Tsai et al., 2012
Fig. 6 from Ghosh et al., 2009
pectoral fin hypoplastic, abnormal standard conditions Fig. 1 with image from Lu et al., 2011
pectoral fin morphology, abnormal standard conditions Fig. 6 from Li et al., 2014
pectoral fin morphology, ameliorated chemical treatment by injection: growth hormone Fig. 6 from Li et al., 2014
pectoral fin truncated, abnormal standard conditions Fig. 1 with image from Tsai et al., 2012
pectoral fin upturned, abnormal standard conditions Fig. 4 with image from Garrity et al., 2002
pectoral fin bud absent, abnormal standard conditions Fig. 6 with image from Fischer et al., 2003
pectoral fin development disrupted, abnormal standard conditions Fig. 5 with image from Pi-Roig et al., 2014
pericardium edematous, abnormal standard conditions Fig. 4 from Ghosh et al., 2017
Fig. 6 from Ghosh et al., 2009
Fig. 1,  Fig. 2 from Lu et al., 2008
somite shape, ameliorated chemical treatment by injection: growth hormone Fig. 6 from Li et al., 2014
somite U-shaped, abnormal standard conditions Fig. 6 from Li et al., 2014
Fig. 1 with image from Tsai et al., 2012
trunk bent, abnormal standard conditions Fig. 1 with image from Tsai et al., 2012
trunk curled, abnormal standard conditions Fig. 1 with image from Lu et al., 2011
trunk decreased length, abnormal standard conditions Fig. 1 with image from Lu et al., 2011
whole organism cdk2 expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 5 with image from Tsai et al., 2012
whole organism badb expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 4 with image from Tsai et al., 2012
whole organism cdkn1bb expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 5 with image from Tsai et al., 2012
whole organism bcl2a expression amount, ameliorated chemical treatment by injection: growth hormone Fig. 4 with image from Tsai et al., 2012
whole organism ghrb expression decreased amount, abnormal standard conditions Fig. 2 with image from Tsai et al., 2012
whole organism akt2 expression decreased amount, abnormal standard conditions Fig. 2 with image from Tsai et al., 2012
whole organism ghra expression decreased amount, abnormal standard conditions Fig. 2 with image from Tsai et al., 2012
whole organism igf1 expression decreased amount, abnormal standard conditions Fig. 2 with image from Tsai et al., 2012
whole organism cdk2 expression increased amount, abnormal standard conditions Fig. 5 with image from Tsai et al., 2012
whole organism bcl2a expression increased amount, abnormal standard conditions Fig. 4 with image from Tsai et al., 2012
whole organism cdkn1bb expression increased amount, abnormal standard conditions Fig. 5 with image from Tsai et al., 2012
whole organism badb expression increased amount, abnormal standard conditions Fig. 4 with image from Tsai et al., 2012
whole organism lacks parts or has fewer parts of type pectoral fin, abnormal standard conditions Fig. 4 with image from Garrity et al., 2002
whole organism semi-lethal (sensu genetics), abnormal standard conditions Fig. 2 from Lu et al., 2008

CITATIONS  (15)