ZFIN ID: ZDB-FIG-111026-19
Lu et al., 2011 - Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos. Journal of Biomedical Science   18:73 Full text @ J. Biomed. Sci.
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 7

Ultrastructural changes of mitochondria and myofibrils in the heart of tbx5-knockdown and wild-type (WT) embryos at 48 h post-fertilization (hpf) under TEM. A: Small mitochondria and well-formed desmosomes can be observed in WT embryos. B: Multiple swollen mitochondria can be observed within myocytes of tbx5 knockdown embryos. C: Well-organized myofibrils with a M line and Z disc can be observed in normal embryos. D: Disarrayed myofibrils appeared in tbx5 knockdown embryos while the M line and Z disc were unrecognizable. E-F: Both the size (E) and number (F) of mitochondria had significantly increased in tbx5 knockdown embryos. Data are presented as the mean ± S.D. An asterisk indicates a significant difference (p < 0.05). mf, myofibril; mt, mitochondria; D, desmosome; ML, M-line; Z, Z-disc; white arrow, disarrayed myofibrils; MO, tbx5 knockdown embryos.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-tbx5a standard conditions Long-pec cardiac muscle cell bicellular tight junction dissociated from cardiac muscle cell bicellular tight junction, abnormal
Long-pec cardiac muscle cell mitochondrion increased amount, abnormal
Long-pec cardiac muscle cell mitochondrion swollen, abnormal
Long-pec myocardium disorganized, abnormal
Long-pec myocardium myofibril disorganized, abnormal
ZFIN wishes to thank the journal Journal of Biomedical Science for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ J. Biomed. Sci.