ZFIN ID: ZDB-FIG-120815-54
Tsai et al., 2012 - The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos. Journal of Biomedical Science   19(1):63 Full text @ J. Biomed. Sci.
Knockdown Reagent:
Observed In:
Stage: Prim-15

Fig. 3 Growth hormone (GH)-treated tbx5 -knockdown zebrafish embryos show reduced apoptosis at 30 h post-fertilization (hpf). A TUNEL assay revealed no apoptotic spots in WT (A), MIS (B), and WTGH (C) embryos. (D) However, massive apoptotic spots were visible in MO embryos. (E) In the MOGH group, apoptotic sites were reduced. (A-E) Embryo anteriors are to the left. Scale bar = 0.1 cm. Black arrow, apoptotic site; WT, wild-type embryos; MO, tbx5 knockdown; MIS, mismatched tbx5-MO-treated embryos; WTGH, WT embryos treated with GH; MOGH, tbx5-MO- and GH-treated embryos.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-tbx5a standard conditions Prim-15 apoptotic process increased occurrence, abnormal
WT + MO1-tbx5a chemical treatment by injection: growth hormone Prim-15 apoptotic process occurrence, ameliorated
ZFIN wishes to thank the journal Journal of Biomedical Science for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ J. Biomed. Sci.