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ZIRC
ZFIN ID: ZDB-GENE-991124-7
Gene Name: T-box transcription factor 5a
Gene Symbol: tbx5a    Nomenclature History

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Previous Names: tbx5.1, tbx5, zf-tbx5, zTbx5, etID310031.5 (1), heartstrings, hst

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including appendage morphogenesis; heart development; and proepicardium development. Localizes to the actin cytoskeleton and nucleus. Used to study Holt-Oram syndrome. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Is expressed in several structures, including eye; immature eye; mesoderm; pectoral fin; and pericardial region. Orthologous to human TBX5 (T-box transcription factor 5).
Genome Resources: Alliance (1),  Gene:30071 (1),  Ensembl(GRCz11):ENSDARG00000024894 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m21 Point Mutation Unknown Premature Stop ENU
tpl58Gt Transgenic Insertion Unknown Unknown DNA
zf2156 Point Mutation Unknown Premature Stop
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tbx5a
2
CRISPR2-tbx5a
1
CRISPR3-tbx5a
1
CRISPR4-tbx5a
1
CRISPR5-tbx5a
1
CRISPR6-tbx5a
1
MO1-tbx5a N/A 27
MO2-tbx5a N/A 9
MO3-tbx5a N/A 3
MO4-tbx5a N/A 4
DISEASE ASSOCIATED WITH tbx5a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Holt-Oram syndrome Alliance Holt-Oram syndrome 142900
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription by RNA polymerase II (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 45)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tbx5a-201 (1)    Ensembl 2059
ncRNA tbx5a-002 (1) 768
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
tbx5a interacts with
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM tbx5a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:dntbx5a,cryaa:GFP) cryaahsp70l GFPtbx5a Danio rerio 1 2
Tg(tbx5a:Cre-ERT2) tbx5a CreERT2 Danio rerio 1 4
Tg(tbx5a:mCherry-2A-Cre-ERT2) tbx5a 2ACreERT2mCherry Danio rerio 1 4
Tg(tbx5a:tdTomato) tbx5a Tomato Danio rerio 1 3
TgBAC(tbx5a:EGFP) tbx5a EGFP Danio rerio 1 2
MARKER RELATIONSHIPS
tbx5a Contained in: [BAC] CH211-245E21 (1) (order this)
tbx5a Encodes: [EST] eu790 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_130915 (1) 2590 bp
Genomic GenBank:CU181811 (1) 144158 bp
Select Tool
Polypeptide UniProtKB:Q9IAK8 (1) 492 aa
Sequence Clusters UniGene:81302 (1)
Sequence Information (all 18)
ORTHOLOGY for tbx5a ( Chr: 5 )
CITATIONS (191)