ZFIN Fish: tbx5a^m21/m21

ZFIN ID: ZDB-FISH-150901-16512

ZFIN ID: ZDB-FISH-150901-16512

Fish name:	tbx5a^m21/m21
Genotype:	tbx5a^m21/m21
Targeting Reagent:	none

HUMAN DISEASE MODELED by tbx5a^m21/m21

Human Disease	Conditions	Citations
Holt-Oram syndrome	standard conditions	Garrity et al., 2002

GENE EXPRESSION
Gene expression in tbx5a^m21/m21

RNA expression

Expressed Gene	Structure	Conditions	Figures
bmp2b	(not) pectoral fin bud	standard conditions	Fig. 8 from Mercader et al., 2006
bmp4	cardiac ventricle (not) fin fold pectoral fin bud heart primordium sinus venosus	standard conditions	Fig. 6 , Fig. 7 , Fig. 9 from Garrity et al., 2002
dlx2a	(not) apical ectodermal ridge pectoral fin bud	standard conditions	Fig. 9 from Garrity et al., 2002
etv4	(not) pectoral fin bud	standard conditions	Fig. 8 from Mercader et al., 2006
fgf10a	(not) pectoral fin bud (not) pectoral fin field	standard conditions	Fig. 8 from Mercader et al., 2006 Fig. 3 from Ng et al., 2002
hand2	heart primordium lateral plate mesoderm (not) mesenchyme pectoral fin	standard conditions	Fig. 6 , Fig. 9 from Garrity et al., 2002
myh7	cardiac ventricle heart primordium presumptive cardiac ventricle heart tube	standard conditions	Fig. 6 , Fig. 7 from Garrity et al., 2002
myl7	heart primordium	standard conditions	Fig. 6 from Garrity et al., 2002
nkx2.5	heart primordium	standard conditions	Fig. 6 from Garrity et al., 2002
prdm1a	(not) pectoral fin field	standard conditions	Fig. 6 from Mercader et al., 2006
shha	(not) mesenchyme pectoral fin	standard conditions	Fig. 9 from Garrity et al., 2002
sp8b	unspecified	standard conditions	text only from Kawakami et al., 2004
sp9	unspecified	standard conditions	text only from Kawakami et al., 2004
tbx5a	cardiac ventricle lateral plate mesoderm mesenchyme pectoral fin (not) pectoral fin bud (not) pectoral fin field presumptive atrium heart tube	standard conditions	Fig. 5 , Fig. 9 from Garrity et al., 2002
vcana	atrium cardiac ventricle	standard conditions	Fig. 7 from Garrity et al., 2002

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab-S46		atrium presumptive atrium heart tube	standard conditions	Fig. 7 from Garrity et al., 2002
Ab-MF20		heart	standard conditions	Fig. 1 from Garrity et al., 2002

Reporter gene expression No data available

PHENOTYPE
Phenotype in tbx5a^m21/m21

Phenotype	Conditions	Figures
blood circulation absent, abnormal	standard conditions	text only from Garrity et al., 2002
heart quality, abnormal	standard conditions	Fig. for (m21) from Phenotype Annotation (1994-2006)
heart contraction decreased frequency, abnormal	standard conditions	text only from Garrity et al., 2002
heart jogging process quality, normal	standard conditions	Fig. 3 from Pi-Roig et al., 2014 text only from Garrity et al., 2002
heart looping arrested, abnormal	standard conditions	Fig. 1 , Fig. 8 from Garrity et al., 2002
heart tube linear, abnormal	standard conditions	Fig. 1 , Fig. 8 from Garrity et al., 2002
heart tube morphology, normal	standard conditions	text only from Garrity et al., 2002
heart tube present, abnormal	standard conditions	Fig. 1 , Fig. 8 from Garrity et al., 2002
heart tube myocardium decreased thickness, abnormal	standard conditions	Fig. 1 from Garrity et al., 2002
mesenchyme pectoral fin flattened, abnormal	standard conditions	Fig. 2 from Garrity et al., 2002
mesenchyme pectoral fin cell population proliferation absent, abnormal	standard conditions	Fig. 2 from Garrity et al., 2002
pectoral fin absent, abnormal	standard conditions	Fig. 1 , Fig. 2 from Garrity et al., 2002
pectoral fin quality, abnormal	standard conditions	Fig. for (m21) from Phenotype Annotation (1994-2006)
pectoral fin bud aplastic, abnormal	standard conditions	Fig. 3 from Ng et al., 2002
pericardium edematous, abnormal	standard conditions	Fig. 1 from Garrity et al., 2002
presumptive cardiac ventricle heart tube decreased size, abnormal	standard conditions	Fig. 8 from Garrity et al., 2002
whole organism dead, abnormal	standard conditions	text only from Garrity et al., 2002

CITATIONS (8)