FIGURE

Figure 3

ID

ZDB-FIG-210814-6

Publication

Tessadori et al., 2021 - Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

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Figure 3

Origin and final positioning of left- and right-originating cardiomyocytes during cardiac looping.

(A) At 28 hpf, as cardiac jogging towards the anterior left side of the embryo is completed, (A’) the tg(0.2Intr1spaw:GFP) labels cardiomyocytes localizing to the superior side of the cardiac tube (section). (B) By 48 hpf cardiac looping morphogenesis is accompanied by displacement in opposite directions of left-originating cardiomyocytes toward the outer curvatures of the ventricle and the atrium (arrowheads in the section and surface view panels). (C) At 48 hpf, the oug mutant heart tube fails to display any constriction at the AV canal and left-originating cardiomyocytes are not visible in the region around the outer curvatures of the cardiac chambers (asterisk; ventricle). Legends: R: Right; L: Left; S: Superior side; I: Inferior side. Scale bars: 50 µm.

Expression Data

Genes:	GFP RFP
Fish:	hu10671Tg/hu10671Tg; hu6531Tg/hu6531Tg; nkuasrfp1aTg/nkuasrfp1aTg
Anatomical Terms:	heart tube right side heart tube superior side
Stage Range:	Prim-5 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hu10671Tg/hu10671Tg; hu6531Tg/hu6531Tg; nkuasrfp1aTg/nkuasrfp1aTg tbx5a^{hu6499/hu6499}; hu10671Tg/hu10671Tg; hu6531Tg/hu6531Tg; nkuasrfp1aTg/nkuasrfp1aTg
Observed In:	cardiac chamber morphogenesis
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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