Ahmed, A., Wei, X., Zhong, D., Ullah, R., Li, W., Jing, L. (2025) The Chromatin Remodeler Chd8 Regulates Hematopoietic Stem and Progenitor Cell Survival and Differentiation During Zebrafish Embryogenesis. International Journal of Molecular Sciences. 26:

Ai, K., Wu, Y., Liang, G., Kong, H., Yang, X., Li, N., Liu, Z., Dong, Y., Xu, J., Zhang, L., Chen, X., Fu, Y., Wang, L., Li, L. (2025) DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development. Communications biology. 8:16121612

Aleman, A.G., Ulloa, B., Nayak, R., Ford, C., Potts, K.S., de Sena-Tomás, C., Vicioso, C., Rangaswamy, U., Elias, H.K., Kharas, M.G., Sanges, R., Bowman, T., Targoff, K.L. (2026) Crip2 preserves hematopoietic stem and progenitor cell production through inhibition of Notch signals. Development (Cambridge, England). :

Amali, A.A., Sie, L., Winkler, C., and Featherstone, M. (2013) Zebrafish hoxd4a Acts Upstream of meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis. PLoS One. 8(3):e58857

Arulmozhivarman, G., Kräter, M., Wobus, M., Friedrichs, J., Bejestani, E.P., Müller, K., Lambert, K., Alexopoulou, D., Dahl, A., Stöter, M., Bickle, M., Shayegi, N., Hampe, J., Stölzel, F., Brand, M., von Bonin, M., Bornhäuser, M. (2017) Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells. Scientific Reports. 7:12084

Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772

Basheer, F., Rasighaemi, P., Liongue, C., Ward, A.C. (2018) Zebrafish G-CSFR maintains neutrophil number and function throughout the lifespan. Infection and Immunity. 87(2):

Berman, J.N., Kanki, J.P., and Look, A.T. (2005) Zebrafish as a model for myelopoiesis during embryogenesis. Experimental hematology. 33(9):997-1006

Bertrand, J.Y., Chi, N.C., Santoso, B., Teng, S., Stainier, D.Y., and Traver, D. (2010) Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 464(7285):108-111

Bertrand, J.Y., Kim, A.D., Teng, S., and Traver, D. (2008) CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development (Cambridge, England). 135(10):1853-1862

Biggs, C.M., Cordeiro-Santanach, A., Prykhozhij, S.V., Deveau, A.P., Lin, Y., Del Bel, K.L., Orben, F., Ragotte, R.J., Saferali, A., Mostafavi, S., Dinh, L., Dai, D., Weinacht, K.G., Dobbs, K., Ott de Bruin, L., Sharma, M., Tsai, K., Priatel, J.J., Schreiber, R.A., Rozmus, J., Hosking, M.C., Shopsowitz, K.E., McKinnon, M.L., Vercauteren, S., Seear, M., Notarangelo, L.D., Lynn, F.C., Berman, J.N., Turvey, S.E. (2022) Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation. JCI insight. 7(24):

Bonkhofer, F., Rispoli, R., Pinheiro, P., Krecsmarik, M., Schneider-Swales, J., Tsang, I.H.C., de Bruijn, M., Monteiro, R., Peterkin, T., Patient, R. (2019) Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nature communications. 10:3577

Bresciani, E., Carrington, B., Wincovitch, S., Jones, M., Gore, A.V., Weinstein, B.M., Sood, R., Liu, P.P. (2014) CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish. Blood. 124(1):70-8

Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A_2bR pathway in zebrafish. Communications biology. 7:615615

Burns, C.E., DeBlasio, T., Zhou, Y., Zhang, J., Zon, L., and Nimer, S.D. (2002) Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Experimental hematology. 30(12):1381-1389

Burns, C.E., Traver, D., Mayhall, E., Shepard, J.L., and Zon, L.I. (2005) Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes & Development. 19(19):2331-2342

Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61

Cacialli, P., Mahony, C.B., Petzold, T., Bordignon, P., Rougemont, A.L., Bertrand, J.Y. (2021) A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress. Nature communications. 12:4484

Cai, P., Mao, X., Zhao, J., Luo, L. (2018) Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochemical and Biophysical Research Communications. 497(2):776-782

Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787

Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53

Chen, H., Wang, S., Dong, R., Yu, P., Li, T., Hu, L., Wang, M., Qian, Z., Zhou, H., Yue, X., Wang, L., Xiao, H. (2025) KDM6A Deficiency Induces Myeloid Bias and Promotes CMML-Like Disease Through JAK/STAT3 Activation by Repressing SOCS3. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e2413091e2413091

Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., Zhang, Y. (2021) Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences. 64(12):2186-2201

Chen, Y., Chan, K.C., Sin, C.F., Zheng, L., Wang, D., Tu, L., He, F., Hui, W.H.J., Leung, H.K., Chan, L.K.F., Tsui, S.P., Chan, H.Y., Ma, A.C.H., Leung, A.Y., Sun, X. (2025) Vulnerability of SRSF2 mutated chronic myelomonocytic leukemia to perturbation of cGAS-STING pathway. Blood advances. :

Chung, M.I., Ma, A.C., Fung, T.K., and Leung, A.Y. (2011) Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis. Experimental hematology. 39(10):986-998.e5

Clements, W.K., Kim, A.D., Ong, K.G., Moore, J.C., Lawson, N.D., and Traver, D. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 474(7350):220-224

Cortes, M., Chen, M.J., Stachura, D.L., Liu, S.Y., Kwan, W., Wright, F., Vo, L.T., Theodore, L.N., Esain, V., Frost, I.M., Schlaeger, T.M., Goessling, W., Daley, G.Q., North, T.E. (2016) Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Reports. 17:458-468

Crosier, P.S., Kalev-Zylinska, M.L., Hall, C.J., Flores, M.V.C., Horsfield, J.A., and Crosier, K.E. (2002) Pathways in blood and vessel development revealed through zebrafish genetics. The International journal of developmental biology. 46(4):493-502

Da'as, S.I., Coombs, A.J., Balci, T.B., Grondin, C.A., Ferrando, A.A., and Berman, J.N. (2012) The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 119(15):3585-3594

Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. (2016) Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43(10):593-600

Danilova, N., Kumagai, A., and Lin, J. (2010) p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes. PLoS One. 5(12):e15938

Darroch, H., Keerthisinghe, P., Sung, Y.J., Rolland, L., Prankerd-Gough, A., Crosier, P.S., Astin, J.W., Hall, C.J. (2023) Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity. Science advances. 9:eadf9904

Davidson, A.J., and Zon, L.I. (2004) The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene. 23(43):7233-7246

De La Garza, A., Cameron, R.C., Nik, S., Payne, S.G., Bowman, T.V. (2016) The Spliceosomal Component Sf3b1 is Essential for Hematopoietic Differentiation in Zebrafish. Experimental hematology. 44(9):826-837.e4

Deveau, A.P., Forrester, A.M., Coombs, A.J., Wagner, G.S., Grabher, C., Chute, I.C., Léger, D., Mingay, M., Alexe, G., Rajan, V., Liwski, R., Hirst, M., Steigmaier, K., Lewis, S.M., Look, A.T., Berman, J.N. (2015) Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98-HOXA9-induced myeloid disease. Leukemia. 29(10):2086-97

Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202

Dobrzycki, T., Mahony, C.B., Krecsmarik, M., Koyunlar, C., Rispoli, R., Peulen-Zink, J., Gussinklo, K., Fedlaoui, B., de Pater, E., Patient, R., Monteiro, R. (2020) Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Communications biology. 3:71

Dooley, K.A., Davidson, A.J., and Zon, L.I. (2005) Zebrafish scl functions independently in hematopoietic and endothelial development. Developmental Biology. 277(2):522-536

Dunn, E.M., Billquist, E.J., VanderStoep, A.L., Bax, P.G., Westrate, L.M., McLellan, L.K., Peterson, S.C., MacKeigan, J.P., Putzke, A.P. (2017) Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development. Biology. 6(4)

Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612

Espín-Palazón, R., Stachura, D.L., Campbell, C.A., García-Moreno, D., Del Cid, N., Kim, A.D., Candel, S., Meseguer, J., Mulero, V., Traver, D. (2014) Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 159:1070-85

Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738

Ferri-Lagneau, K.F., Haider, J., Sang, S., Leung, T. (2019) Rescue of hematopoietic stem/progenitor cells formation in plcg1 zebrafish mutant. Scientific Reports. 9:244

Fraint, E., Feliz Norberto, M., Bowman, T.V. (2020) A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish. Blood advances. 4:6189-6198

Fu, Y.F., Du, T.T., Dong, M., Zhu, K.Y., Jing, C.B., Zhang, Y., Wang, L., Fan, H.B., Chen, Y., Jin, Y., Yue, G.P., Chen, S.J., Chen, Z., Huang, Q.H., Jing, Q., Deng, M., and Liu, T.X. (2009) Mir-144 selectively regulates embryonic {alpha}-hemoglobin synthesis during primitive erythropoiesis. Blood. 113(6):1340-1349

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Developmental Cell. 8(1):109-116

Gao, X., Wu, T., Johnson, K.D., Lahvic, J.L., Ranheim, E.A., Zon, L.I., Bresnick, E.H. (2016) GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 6(3):368-82

Gau, P., Curtright, A., Condon, L., Raible, D.W., Dhaka, A. (2017) An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish. PLoS Genetics. 13:e1006884

Genthe, J.R., Clements, W.K. (2017) R-spondin-1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development (Cambridge, England). 144(4):590-600

Gering, M., Yamada, Y., Rabbitts, T.H., and Patient, R.K. (2003) Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development (Cambridge, England). 130:6287-6199

Ghersi, J.J., Mahony, C.B., Bertrand, J.Y. (2019) bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish. Development (Cambridge, England). 146(6):

Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., and Zon, L.I. (2009) Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136(6):1136-1147

Gong, G., Kam, H., Tse, Y., Lee, S.M. (2019) Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes. Chemosphere. 235:153-162

Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730

Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J.D., Wang, R., Xiong, F., Meng, S., Clements, T.P., Tandon, B., Wagner, D.S., Diaz, M.F., Wenzel, P.L., Miller, Y.I., Traver, D., Cooke, J.P., Li, W., Zon, L.I., Chen, K., Bai, Y., Fang, L. (2019) AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science (New York, N.Y.). 363:1085-1088

Hall, C.J., Flores, M.V., Oehlers, S.H., Sanderson, L.E., Lam, E.Y., Crosier, K.E., and Crosier, P.S. (2012) Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide. Cell Stem Cell. 10(2):198-209

Han, S.H., Kim, S.H., Kim, H.J., Lee, Y., Choi, S.Y., Park, G., Kim, D.H., Lee, A., Kim, J., Choi, J.M., Kim, Y., Myung, K., Kim, H., Kim, D.W. (2017) Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia. Leukemia. 31(7):1532-1539

Han, Y., Shao, W., Zhong, D., Ma, C., Wei, X., Ahmed, A., Yu, T., Jing, W., Jing, L. (2021) Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients. Biomolecules. 11(3):

Hariom, S.K., Nelson, E.J.R. (2022) Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish. Life sciences in space research. 34:21-29

He, B.L., Yang, N., Man, C.H., Ng, N.K., Cher, C.Y., Leung, H.C., Kan, L.L., Cheng, B.Y., Lam, S.S., Wang, M.L., Zhang, C.X., Kwok, H., Cheng, G., Sharma, R., Ma, A.C., So, C.E., Kwong, Y.L., Leung, A.Y. (2020) Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. EMBO Molecular Medicine. 12(4):e10895

He, S., Chen, J., Jiang, Y., Wu, Y., Zhu, L., Jin, W., Zhao, C., Yu, T., Wang, T., Wu, S., Lin, X., Qu, J.Y., Wen, Z., Zhang, W., Xu, J. (2018) Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. eLIFE. 7

Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696

Hirabayashi, R., Hozumi, S., Higashijima, S.I., and Kikuchi, Y. (2013) Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish. Stem cells and development. 22(18):2532-42

Horsfield, J.A., Anagnostou, S.H., Hu, J.K., Cho, K.H., Geisler, R., Lieschke, G., Crosier, K.E., and Crosier, P.S. (2007) Cohesin-dependent regulation of Runx genes. Development (Cambridge, England). 134(14):2639-2649

Hrit, J., Goodrich, L., Li, C., Wang, B.A., Nie, J., Cui, X., Martin, E.A., Simental, E., Fernandez, J., Liu, M.Y., Nery, J.R., Castanon, R., Kohli, R.M., Tretyakova, N., He, C., Ecker, J.R., Goll, M., Panning, B. (2018) OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. eLIFE. 7:

Hsu, J., Huang, H.T., Lee, C.T., Choudhuri, A., Wilson, N.K., Abraham, B.J., Moignard, V., Kucinski, I., Yu, S., Hyde, R.K., Tober, J., Cai, X., Li, Y., Guo, Y., Yang, S., Superdock, M., Trompouki, E., Calero-Nieto, F.J., Ghamari, A., Jiang, J., Gao, P., Gao, L., Nguyen, V., Robertson, A.L., Durand, E.M., Kathrein, K.L., Aifantis, I., Gerber, S.A., Tong, W., Tan, K., Cantor, A.B., Zhou, Y., Liu, P.P., Young, R.A., Göttgens, B., Speck, N.A., Zon, L.I. (2020) CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. 117(38):23626-23635

Huang, C., Gu, S., Yu, P., Yu, F., Feng, C., Gao, N., and Du, J. (2010) Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Developmental Biology. 339(1):89-100

Huang, M., Ahmed, A., Wang, W., Wang, X., Ma, C., Jiang, H., Li, W., Jing, L. (2022) Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish. International Journal of Molecular Sciences. 23(7):

Huang, Z., Chen, K., Chi, Y., Jin, H., Li, L., Zhang, W., Xu, J., Zhang, Y. (2021) Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. The Journal of biological chemistry. 296:100272

Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J., Raftopoulou, C., Murphey, R.D., Bayliss, P.E., Imai, Y., Burns, C.E., Masutomi, K., Gagos, S., Zon, L.I., Roberts, T.M., and Kishi, S. (2008) A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 3(10):e3364

Jagannathan-Bogdan, M., and Zon, L.I. (2013) Hematopoiesis. Development (Cambridge, England). 140(12):2463-2467

Jia, Q., Zhang, Q., Zhang, Z., Wang, Y., Zhang, W., Zhou, Y., Wan, Y., Cheng, T., Zhu, X., Fang, X., Yuan, W., and Jia, H. (2013) Transcriptome Analysis of the Zebrafish Model of Diamond-Blackfan Anemia from RPS19 Deficiency via p53-Dependent and -Independent Pathways. PLoS One. 8(8):e71782

Jiang, Z., Carlantoni, C., Allanki, S., Ebersberger, I., Stainier, D.Y.R. (2020) Tek/Tie2 is not required for cardiovascular development in zebrafish. Development (Cambridge, England). 147(19):

Jin, H., Sood, R., Xu, J., Zhen, F., English, M.A., Liu, P.P., and Wen, Z. (2009) Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development (Cambridge, England). 136(4):647-654

Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V., Postlethwait, J.H., Chau, J.Y., Cattin, P.M., Vitas, M.R., Crosier, P.S., and Crosier, K.E. (2003) Runx3 is required for hematopoietic development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):323-336

Kang, J.W., Kim, Y., Lee, Y., Myung, K., Kim, Y.H., Oh, C.K. (2020) AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation. Journal of cellular biochemistry. 122(3-4):403-412

Kataoka, H., Ochi, M., Enomoto, K., and Yamaguchi, A. (2000) Cloning and embryonic expression patterns of the zebrafish Runt domain genes, runxa and runxb. Mechanisms of Development. 98(1-2):139-143

Keightley, M.C., Crowhurst, M.O., Layton, J.E., Beilharz, T., Markmiller, S., Varma, S., Hogan, B.M., de Jong-Curtain, T.A., Heath, J.K., and Lieschke, G.J. (2013) In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. FEBS letters. 587(14):2150-2157

Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545

Kim, P.G., Albacker, C.E., Lu, Y.F., Jang, I.H., Lim, Y., Heffner, G.C., Arora, N., Bowman, T.V., Lin, M.I., Lensch, M.W., De Los Angeles, A., Zon, L.I., Loewer, S., and Daley, G.Q. (2013) Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proceedings of the National Academy of Sciences of the United States of America. 110(2):E141-150

Kissa, K., Murayama, E., Zapata, A., Cortes, A., Perret, E., Machu, C., and Herbomel, P. (2008) Live imaging of emerging hematopoietic stem cells and early thymus colonization. Blood. 111(3):1147-1156

Klaus, A., Clapes, T., Yvernogeau, L., Basu, S., Weijts, B., Maas, J., Smal, I., Galjart, N., Robin, C. (2022) CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development. Cell Reports. 39:110957

Kobayashi, I., Kobayashi-Sun, J., Kim, A.D., Pouget, C., Fujita, N., Suda, T., Traver, D. (2014) Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 512(7514):319-23

Konantz, M., Alghisi, E., Müller, J.S., Lenard, A., Esain, V., Carroll, K.J., Kanz, L., North, T.E., Lengerke, C. (2016) Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. The EMBO journal. 35(21):2315-2331

Koth, J., Wang, X., Killen, A.C., Stockdale, W.T., Potts, H.G., Jefferson, A., Bonkhofer, F., Riley, P.R., Patient, R.K., Göttgens, B., Mommersteeg, M.T.M. (2020) Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. Development (Cambridge, England). 147(8)

Kramer, J., Granier, C.J., Davis, S., Piso, K., Hand, J., Rabson, A.B., and Sabaawy, H.E. (2013) PDCD2 controls hematopoietic stem cell differentiation during development. Stem cells and development. 22(1):58-72

Kulkeaw, K., Ishitani, T., Kanemaru, T., Fucharoen, S., and Sugiyama, D. (2010) Cold exposure down-regulates zebrafish hematopoiesis. Biochemical and Biophysical Research Communications. 394(4):859-864

Kwon, H.B., Mackie, D.I., Bonnavion, R., Mercier, A.L., Helker, C.S.M., Son, T., Guenter, S., Serafin, D.S., Kim, K.W., Offermanns, S., Caron, K.M., Stainier, D.Y.R. (2020) The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS pharmacology & translational science. 3:676-689

Lahvic, J.L., Ammerman, M., Li, P., Blair, M.C., Stillman, E.R., Fast, E.M., Robertson, A.L., Christodoulou, C., Perlin, J.R., Yang, S., Chiang, N., Norris, P.C., Daily, M.L., Redfield, S.E., Chan, I.T., Chatrizeh, M., Chase, M.E., Weis, O., Zhou, Y., Serhan, C.N., Zon, L.I. (2018) Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proceedings of the National Academy of Sciences of the United States of America. 115(37):9252-9257

Lam, E.Y., Hall, C.J., Crosier, P.S., Crosier, K.E., and Flores, M.V. (2010) Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells. Blood. 116(6):909-914

Laverde, V., Loges, L., Sumanas, S. (2025) Zebrafish ETS transcription factor Fli1b functions upstream of Scl/Tal1 during embryonic hematopoiesis. Biology Open. :

Lee, H., Kim, E.K., Ju, H.Y., Lee, C.R., Ahn, S., Kim, E.S., Myung, K., Kim, W.K., Cho, S.Y., Kwon, Y., Kim, D., Yu, Y., Kwon, E.J., Kim, H., Mun, S.I., Lim, D.M., Kim, K., Heo, H.J., Baek, S.E., Lee, S.Y., Cho, H., Choi, E.Y., Goh, T.S., Baryawno, N., Lee, D., Jung, K.S., Yoo, K.H., Oh, C.K., Kim, Y.H. (2025) AP2M1 Amplification Orchestrates Notch-Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e14566e14566

Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nature communications. 5:5583

Lenard, A., Alghisi, E., Daff, H., Donzelli, M., McGinnis, C., Lengerke, C. (2016) Using zebrafish to model erythroid lineage toxicity and regeneration. Haematologica. 101(5):e164-7

Li, C., Lan, Y., Schwartz-Orbach, L., Korol, E., Tahiliani, M., Evans, T., Goll, M.G. (2015) Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence. Cell Reports. 12(7):1133-43

Li, F.F., Liang, Y.L., Han, X.S., Guan, Y.N., Chen, J., Wu, P., Zhao, X.X., Jing, Q. (2020) ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1. Acta Pharmacologica Sinica. 42(3):414-421

Li, L., Chen, D., Li, J., Wang, X., Wang, N., Xu, C., and Wang, Q.K. (2014) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood. 123(4):501-8

Li, L., Yan, B., Shi, Y.Q., Zhang, W.Q., and Wen, Z.L. (2012) Live imaging reveals differing roles of macrophages and neutrophils during Zebrafish tail fin regeneration. The Journal of biological chemistry. 287(30):25353-25360

Li, R.A., Traver, D., Matthes, T., Bertrand, J.Y. (2016) Ndrg1b and fam49ab modulate the PTEN pathway to control T cell lymphopoiesis in the zebrafish. Blood. 128(26):3052-3060

Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I.M., Yzaguirre, A.D., Cai, X., Cortes, M., Maijenburg, M.W., Tober, J., Dzierzak, E., Orkin, S.H., Tan, K., North, T.E., Speck, N.A. (2014) Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28(23):2597-612

Li, Y., Tang, C., Liu, F., Zhu, C., Liu, F., Zhu, P., Wang, L. (2022) DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development (Cambridge, England). 149(10):

Lim, S.E., Esain, V., Kwan, W., Theodore, L.N., Cortes, M., Frost, I.M., Liu, S.Y., North, T.E. (2017) HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology. 46:83-95.e6

Lin, Q., Zhang, Y., Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., Zhang, Y. (2017) Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31(5):1206-1216

Liu, F., Yao, S., Zhang, T., Xiao, C., Shang, Y., Liu, J., and Mo, X. (2012) Kzp Regulates the Transcription of gata2 and pu.1 During Primitive Hematopoiesis in Zebrafish Embryos. Journal of genetics and genomics = Yi chuan xue bao. 39(9):463-471

Liu, X., Jia, X., Yuan, H., Ma, K., Chen, Y., Jin, Y., Deng, M., Pan, W., Chen, S., Chen, Z., de The, H., Zon, L.I., Zhou, Y., Zhou, J., Zhu, J. (2015) DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Journal of Hematology & Oncology. 8:15

Liu, Y., Lin, Z., Peng, Y., Jiang, Y., Zhang, X., Zhu, H., Zhang, L., Chen, J., Shu, X., Luo, M., Xie, D., Chen, Y., Liao, H., Liu, M., Zhang, X., Liu, S., Wang, H., Zhou, B., Sun, H. (2022) Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome. Cell Death & Disease. 13:10541054

Lu, J.W., Hsieh, M.S., Hou, H.A., Chen, C.Y., Tien, H.F., Lin, L.I. (2017) Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood cancer journal. 7:e593

Lu, X., Wei, Y., Liu, F. (2015) Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell discovery. 1:15027

Lundin, V., Sugden, W.W., Theodore, L.N., Sousa, P.M., Han, A., Chou, S., Wrighton, P.J., Cox, A.G., Ingber, D.E., Goessling, W., Daley, G.Q., North, T.E. (2020) YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental Cell. 52(4):446-460.e5

Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):

Ma, A.C., Chung, M.I., Liang, R., and Leung, A.Y. (2010) A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia. 24(12):2090-2099

Macaulay, I.C., Svensson, V., Labalette, C., Ferreira, L., Hamey, F., Voet, T., Teichmann, S.A., Cvejic, A. (2016) Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Reports. 14(4):966-77

Mahony, C.B., Copper, L., Vrljicak, P., Noyvert, B., Constantinidou, C., Browne, S., Pan, Y., Palles, C., Ott, S., Higgs, M.R., Monteiro, R. (2023) Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency. Cell Reports. 42:112571112571

Mahony, C.B., Pasche, C., Bertrand, J.Y. (2018) Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Stem Cell Reports. 10(6):1920-1934

Mandriani, B., Castellana, S., Rinaldi, C., Manzoni, M., Venuto, S., Rodriguez-Aznar, E., Galceran, J., Nieto, M.A., Borsani, G., Monti, E., Mazza, T., Merla, G., Micale, L. (2016) Identification of p53-target genes in Danio rerio. Scientific Reports. 6:32474

Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):

Martínez-López, M.F., de Almeida, C.R., Fontes, M., Mendes, R.V., Kaufmann, S.H.E., Fior, R. (2024) Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy. Disease models & mechanisms. 17(8):

Mazzola, M., Pezzotta, A., Fazio, G., Rigamonti, A., Bresciani, E., Gaudenzi, G., Pelleri, M.C., Saitta, C., Ferrari, L., Parma, M., Fumagalli, M., Biondi, A., Cazzaniga, G., Marozzi, A., Pistocchi, A. (2020) Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects. Journal of Cellular and Molecular Medicine. 24(11):6272-6282

McKinney-Freeman, S., Cahan, P., Li, H., Lacadie, S.A., Huang, H.T., Curran, M., Loewer, S., Naveiras, O., Kathrein, K.L., Konantz, M., Langdon, E.M., Lengerke, C., Zon, L.I., Collins, J.J., and Daley, G.Q. (2012) The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 11(5):701-714

Meier, N., Krpic, S., Rodriguez, P., Strouboulis, J., Monti, M., Krijgsveld, J., Gering, M., Patient, R., Hostert, A., and Grosveld, F. (2006) Novel binding partners of Ldb1 are required for haematopoietic development. Development (Cambridge, England). 133(24):4913-4923

Mommaerts, H., Esguerra, C.V., Hartmann, U., Luyten, F.P., Tylzanowski, P. (2014) Smoc2 modulates embryonic myelopoiesis during zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(11):1375-90

Monteiro, R., Pouget, C., and Patient, R. (2011) The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. The EMBO journal. 30(6):1093-1103

Murayama, E., Kissa, K., Zapata, A., Mordelet, E., Briolat, V., Lin, H.F., Handin, R.I., and Herbomel, P. (2006) Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development. Immunity. 25(6):963-975

Nah, G.S., Lim, Z.W., Tay, B.H., Osato, M., Venkatesh, B. (2014) Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii). PLoS One. 9:e93816

North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I. (2009) Hematopoietic stem cell development is dependent on blood flow. Cell. 137(4):736-748

Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611

Oehlers, S.H., Flores, M.V., Hall, C.J., Swift, S., Crosier, K.E., and Crosier, P.S. (2011) The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Disease models & mechanisms. 4(6):832-41

Oh, C.K., Kim, M.S., Shin, U., Kang, J.W., Kim, Y.H., Ko, H.S., Ra, J.S., Ahn, S., Choi, E.Y., Yu, S., Nam, U., Choi, T., Myung, K., Lee, Y. (2025) SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. Journal of Cellular Physiology. 240:e70023e70023

Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366

Patterson, L.J., Gering, M., and Patient, R. (2005) Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood. 105(9):3502-3511

Peng, X., Dong, M., Ma, L., Jia, X.E., Mao, J., Jin, C., Chen, Y., Gao, L., Liu, X., Ma, K., Wang, L., Du, T., Jin, Y., Huang, Q., Li, K., Zon, L.I., Liu, T., Deng, M., Zhou, Y., Xi, X., Zhou, Y., Chen, S. (2015) A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 29(12):2355-65

Pessoa Rodrigues, C., Collins, J.M., Yang, S., Martinez, C., Kim, J.W., Lama, C., Nam, A.S., Alt, C., Lin, C., Zon, L.I. (2024) Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science (New York, N.Y.). 385:eadn1629eadn1629

Petzold, T., Brivio, S., Linnerz, T., Watanabe, M., Gerhardt, H., Bertrand, J.Y. (2025) Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification. Biology Open. :

Peña, O.A., Lubin, A., Rowell, J., Hoade, Y., Khokhar, N., Lemmik, H., Mahony, C., Dace, P., Umamahesan, C., Payne, E.M. (2021) Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Frontiers in cell and developmental biology. 9:708113

Pimtong, W., Datta, M., Ulrich, A.M., Rhodes, J. (2014) Drl.3 governs primitive hematopoiesis in zebrafish. Scientific Reports. 4:5791

Pistocchi, A., Chiricozzi, E., Molteni, M., Galassi, G., Mauri, L., Balistreri, F., Magri, S., Marozzi, A., Taroni, F., Pezzotta, A. (2026) Neurotrophic Modulation Restores Motor and Developmental Defects in Zebrafish Models of ints11 Deficiency. Journal of neurochemistry. 170:e70408e70408

Potts, K.S., Cameron, R.C., Metidji, A., Ghazale, N., Wallace, L., Leal-Cervantes, A.I., Palumbo, R., Barajas, J.M., Gupta, V., Aluri, S., Pradhan, K., Myers, J.A., McKinstry, M., Bai, X., Choudhary, G.S., Shastri, A., Verma, A., Obeng, E.A., Bowman, T.V. (2022) Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition. Cell Reports. 41:111825111825

Progatzky, F., Taylor, H., Bugeon, L., Cassidy, S., Radbruch, A., Dallman, M.J., and Lamb, J.R. (2012) The role of Nfil3 in zebrafish hematopoiesis. Developmental and comparative immunology. 38(1):187-192

Póvoa, V., Rebelo de Almeida, C., Maia-Gil, M., Sobral, D., Domingues, M., Martinez-Lopez, M., de Almeida Fuzeta, M., Silva, C., Grosso, A.R., Fior, R. (2021) Innate immune evasion revealed in a colorectal zebrafish xenograft model. Nature communications. 12:1156

Quillien, A., Gilbert, G., Boulet, M., Ethuin, S., Waltzer, L., Vandel, L. (2021) Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity. PLoS Genetics. 17:e1009641

Rao, A., Russell, A., Segura-Bermudez, J., Franz, C., Dockery, R., Blatnik, A., Panten, J., Zevallos, M., McNulty, C., Pietrzak, M., Goldman, J.A. (2025) A cardiac transcriptional enhancer is repurposed during regeneration to activate an anti-proliferative program. Development (Cambridge, England). :

Ren, C.G., Wang, L., Jia, X.E., Liu, Y.J., Dong, Z.W., Jin, Y., Chen, Y., Deng, M., Zhou, Y., Zhou, Y., Ren, R.B., Pan, W.J., and Liu, T.X. (2013) Activated N-Ras signaling regulates arterial-venous specification in zebrafish. Journal of Hematology & Oncology. 6:34

Rho, S.S., Kobayashi, I., Oguri-Nakamura, E., Ando, K., Fujiwara, M., Kamimura, N., Hirata, H., Iida, A., Iwai, Y., Mochizuki, N., Fukuhara, S. (2019) Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Developmental Cell. 49(5):681-696.e6

Rissone, A., Weinacht, K.G., la Marca, G., Bishop, K., Giocaliere, E., Jagadeesh, J., Felgentreff, K., Dobbs, K., Al-Herz, W., Jones, M., Chandrasekharappa, S., Kirby, M., Wincovitch, S., Simon, K.L., Itan, Y., DeVine, A., Schlaeger, T., Schambach, A., Sood, R., Notarangelo, L.D., Candotti, F. (2015) Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. The Journal of experimental medicine. 212(8):1185-202

Sawamiphak, S., Kontarakis, Z., Stainier, D.Y. (2014) Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence. Developmental Cell. 31:640-653

Sertori, R., Truong, B., Singh, M.K., Shinton, S., Price, R., Sharo, A., Shultes, P., Sunderam, U., Rana, S., Srinivasan, R., Datta, S., Font-Burgada, J., Brenner, S.E., Puck, J.M., Wiest, D.L. (2025) Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Frontiers in immunology. 16:15398481539848

Shen, L.J., Chen, F.Y., Zhang, Y., Cao, L.F., Kuang, Y., Zhong, M., Wang, T., and Zhong, H. (2013) MYCN Transgenic Zebrafish Model with the Characterization of Acute Myeloid Leukemia and Altered Hematopoiesis. PLoS One. 8(3):e59070

Shi, X., Liu, Y., Huang, L., Ou, Y., Chen, X., Ling, Y., Zhang, Y., Lin, Q. (2025) Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis. Cell communication and signaling : CCS. 23:544544

Shu, L.P., Zhou, Z.W., Zhou, T., Deng, M., Dong, M., Chen, Y., Fu, Y.F., Jin, Y., Zhou, S.F., He, Z.X. (2015) Ectopic expression of Hoxb4a in hemangioblasts promotes hematopoietic development in early embryogenesis of zebrafish. Clinical and experimental pharmacology & physiology. 42:1275-86

Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727

Sood, R., English, M.A., Belele, C.L., Jin, H., Bishop, K., Haskins, R., McKinney, M.C., Chahal, J., Weinstein, B.M., Wen, Z., and Liu, P.P. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 115(14):2806-2809

Stachura, D.L., Svoboda, O., Campbell, C.A., Espín-Palazón, R., Lau, R.P., Zon, L.I., Bartunek, P., and Traver, D. (2013) The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 122(24):3918-28

Sun, H., Wang, Y., Zhang, J., Chen, Y., Liu, Y., Lin, Z., Liu, M., Sheng, K., Liao, H., Tsang, K.S., Zhang, X., Jiang, X., Xu, W., Mao, M., Chan, H.C. (2018) CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis. Cell Death & Disease. 9:275

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Tamaoki, J., Maeda, H., Kobayashi, I., Takeuchi, M., Ohashi, K., Gore, A., Bonkhofer, F., Patient, R., Weinstein, B.M., Kobayashi, M. (2023) LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 501:92-103

Theodore, L.N., Hagedorn, E.J., Cortes, M., Natsuhara, K., Liu, S.Y., Perlin, J.R., Yang, S., Daily, M.L., Zon, L.I., North, T.E. (2017) Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 8(5):1226-1241

Tie, R., Li, H., Cai, S., Liang, Z., Shan, W., Wang, B., Tan, Y., Zheng, W., Huang, H. (2019) Interleukin-6 signaling regulates hematopoietic stem cell emergence. Experimental & molecular medicine. 51:1-12

Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008

Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6

Wan, X., Hu, B., Liu, J.X., Feng, X., and Xiao, W. (2011) Zebrafish mll is essential for haematopoiesis. The Journal of biological chemistry. 286(38):33345-57

Wang, D., Zheng, L., Cheng, B.Y.L., Sin, C.F., Li, R., Tsui, S.P., Yi, X., Ma, A.C.H., He, B.L., Leung, A.Y.H., Sun, X. (2023) Transgenic IDH2^R172K and IDH2^R140Q zebrafish models recapitulated features of human acute myeloid leukemia. Oncogene. 42(16):1272-1281

Wang, L., Wang, X., Wang, L., Yousaf, M., Li, J., Zuo, M., Yang, Z., Gou, D., Bao, B., Li, L., Xiang, N., Jia, H., Xu, C., Chen, Q., Wang, Q.K. (2017) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1):183-194

Wang, S., He, Q., Ma, D., Xue, Y., Liu, F. (2015) Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Developmental Cell. 34(6):621-31

Wang, T., Yan, B., Lou, L., Lin, X., Yu, T., Wu, S., Lu, Q., Liu, W., Huang, Z., Zhang, M., Zhang, W., Wen, Z. (2019) Nlrc3-like is required for microglia maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 46(6):291-299

Wei, Y., Ma, D., Gao, Y., Zhang, C., Wang, L., Liu, F. (2014) Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood. 124(10):1578-85

Weinreb, J.T., Ghazale, N., Pradhan, K., Gupta, V., Potts, K.S., Tricomi, B., Daniels, N.J., Padgett, R.A., De Oliveira, S., Verma, A., Bowman, T.V. (2021) Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Developmental Cell. 56(5):627-640.e5

Wilkinson, R.N., Koudijs, M.J., Patient, R.K., Ingham, P.W., Schulte-Merker, S., and van Eeden, F.J. (2012) Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood. 120(2):477-488

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Xia, J., Liu, M., Zhu, C., Liu, S., Ai, L., Ma, D., Zhu, P., Wang, L., Liu, F. (2023) Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Research. 33(6):448-463

Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z. (2015) Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish. Developmental Cell. 34:632-641

Xu, Y., Guo, R., Huang, T., Guo, C. (2024) miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway. Cell death discovery. 10:209209

Yang, F., Hu, H., Liu, Y., Shao, M., Shao, C., Gong, Y. (2019) Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death & Disease. 10:388

Yang, R., Yan, S., Zhu, X., Li, C.Y., Liu, Z., Xiong, J.W. (2015) Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish. Experimental hematology. 43(4):331-341.e8

Yeh, J.R., Munson, K.M., Chao, Y.L., Peterson, Q.P., MacRae, C.A., and Peterson, R.T. (2008) AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (Cambridge, England). 135(2):401-410

Yiqin, W., Ruimeng, Y., Peihong, W., Xiaohui, L., Hao, Y., Hongli, H., Yongjian, Z., Baoshu, X. (2025) Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP-Notch1-Spi1/Cebpα Axis to Promote Neutrophil Fate. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e05441e05441

Yu, T., Kuang, H., Wu, X., Huang, Y., Wang, J., Wen, Z. (2023) Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia. Science advances. 9:eadf9790

Yue, Y., Tang, Y., Huang, H., Zheng, D., Liu, C., Zhang, H., Liu, Y., Li, Y., Sun, X., Lu, L. (2023) VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. The Journal of biological chemistry. 299(6):104829

Zhan, Y., Huang, Y., Chen, J., Cao, Z., He, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2018) The caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao.

Zhang, C., Chen, Y., Sun, B., Wang, L., Yang, Y., Ma, D., Lv, J., Heng, J., Ding, Y., Xue, Y., Lu, X., Xiao, W., Yang, Y.G., Liu, F. (2017) m⁶A modulates haematopoietic stem and progenitor cell specification.. Nature. 549(7671):273-276

Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107

Zhang, X.Y., and Rodaway, A.R. (2007) SCL-GFP transgenic zebrafish: In vivo imaging of blood and endothelial development and identification of the initial site of definitive hematopoiesis. Developmental Biology. 307(2):179-194

Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101

Zhao, S., Feng, S., Tian, Y., Wen, Z. (2022) Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. Proceedings of the National Academy of Sciences of the United States of America. 119:e2119051119e2119051119

Zhao, Y., Wu, M., Li, J., Meng, P., Chen, J., Huang, Z., Xu, J., Wen, Z., Zhang, W., Zhang, Y. (2021) The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Cell Death & Disease. 12:906

Zhong, D., Jiang, H., Zhou, C., Ahmed, A., Li, H., Wei, X., Lian, Q., Tastemel, M., Xin, H., Ge, M., Zhang, C., Jing, L. (2023) The microbiota regulates hematopoietic stem and progenitor cell development by mediating inflammatory signals in the niche. Cell Reports. 42:112116112116

Zhou, W., He, Q., Zhang, C., He, X., Cui, Z., Liu, F., Li, W. (2016) BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. eLIFE. 5

Aleman, A.G., Ulloa, B., Nayak, R., Ford, C., Potts, K.S., de Sena-Tomás, C., Vicioso, C., Rangaswamy, U., Elias, H.K., Kharas, M.G., Sanges, R., Bowman, T., Targoff, K.L. (2026) Crip2 preserves hematopoietic stem and progenitor cell production through inhibition of Notch signals. Development (Cambridge, England). :

Ahmed, A., Wei, X., Zhong, D., Ullah, R., Li, W., Jing, L. (2025) The Chromatin Remodeler Chd8 Regulates Hematopoietic Stem and Progenitor Cell Survival and Differentiation During Zebrafish Embryogenesis. International Journal of Molecular Sciences. 26:

Ai, K., Wu, Y., Liang, G., Kong, H., Yang, X., Li, N., Liu, Z., Dong, Y., Xu, J., Zhang, L., Chen, X., Fu, Y., Wang, L., Li, L. (2025) DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development. Communications biology. 8:16121612

Chen, Y., Chan, K.C., Sin, C.F., Zheng, L., Wang, D., Tu, L., He, F., Hui, W.H.J., Leung, H.K., Chan, L.K.F., Tsui, S.P., Chan, H.Y., Ma, A.C.H., Leung, A.Y., Sun, X. (2025) Vulnerability of SRSF2 mutated chronic myelomonocytic leukemia to perturbation of cGAS-STING pathway. Blood advances. :

Kocere, A., Chiavacci, E., Soneson, C., Jacobson, S.T., Harrison, E.N., Méndez-Acevedo, K.M., MacGowan, J.S., Wells, H.H., Hiltabidle, M.S., Raghunath, A., Shavit, J.A., Panáková, D., Williams, M.L.K., Robinson, M.D., Mosimann, C., Burger, A. (2025) Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling. Developmental Biology. :

Lee, H., Kim, E.K., Ju, H.Y., Lee, C.R., Ahn, S., Kim, E.S., Myung, K., Kim, W.K., Cho, S.Y., Kwon, Y., Kim, D., Yu, Y., Kwon, E.J., Kim, H., Mun, S.I., Lim, D.M., Kim, K., Heo, H.J., Baek, S.E., Lee, S.Y., Cho, H., Choi, E.Y., Goh, T.S., Baryawno, N., Lee, D., Jung, K.S., Yoo, K.H., Oh, C.K., Kim, Y.H. (2025) AP2M1 Amplification Orchestrates Notch-Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e14566e14566

Petzold, T., Brivio, S., Linnerz, T., Watanabe, M., Gerhardt, H., Bertrand, J.Y. (2025) Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification. Biology Open. :

Sertori, R., Truong, B., Singh, M.K., Shinton, S., Price, R., Sharo, A., Shultes, P., Sunderam, U., Rana, S., Srinivasan, R., Datta, S., Font-Burgada, J., Brenner, S.E., Puck, J.M., Wiest, D.L. (2025) Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Frontiers in immunology. 16:15398481539848

Shi, X., Liu, Y., Huang, L., Ou, Y., Chen, X., Ling, Y., Zhang, Y., Lin, Q. (2025) Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis. Cell communication and signaling : CCS. 23:544544

Zhang, B., Zhu, Y., Tang, Y., Liu, L., Liu, Y., Li, Y., Yu, W., Lu, L. (2025) The mediator subunit complex protein MED15 promotes lipid deposition and cancer progression during hypoxia. The Journal of biological chemistry. :108296108296

Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787

Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m⁶A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014

Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):

Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110

Martínez-López, M.F., de Almeida, C.R., Fontes, M., Mendes, R.V., Kaufmann, S.H.E., Fior, R. (2024) Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy. Disease models & mechanisms. 17(8):

Miladinovic, O., Canto, P.Y., Pouget, C., Piau, O., Radic, N., Freschu, P., Megherbi, A., Prats, C.B., Jacques, S., Hirsinger, E., Geeverding, A., Dufour, S., Petit, L., Souyri, M., North, T., Isambert, H., Traver, D., Jaffredo, T., Charbord, P., Durand, C. (2024) A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche. Development (Cambridge, England). 151(7):

Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290

Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.

Cacialli, P., Dogan, S., Linnerz, T., Pasche, C., Bertrand, J.Y. (2023) Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 18:153415461534-1546

Darroch, H., Keerthisinghe, P., Sung, Y.J., Rolland, L., Prankerd-Gough, A., Crosier, P.S., Astin, J.W., Hall, C.J. (2023) Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity. Science advances. 9:eadf9904

He, X., Ge, C., Xia, J., Xia, Z., Zhao, L., Huang, S., Wang, R., Pan, J., Cheng, T., Xu, P.F., Wang, F., Min, J. (2023) The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(17):e2205345

Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508

Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406

Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010

Mahony, C.B., Copper, L., Vrljicak, P., Noyvert, B., Constantinidou, C., Browne, S., Pan, Y., Palles, C., Ott, S., Higgs, M.R., Monteiro, R. (2023) Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency. Cell Reports. 42:112571112571

Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727

Wang, D., Zheng, L., Cheng, B.Y.L., Sin, C.F., Li, R., Tsui, S.P., Yi, X., Ma, A.C.H., He, B.L., Leung, A.Y.H., Sun, X. (2023) Transgenic IDH2^R172K and IDH2^R140Q zebrafish models recapitulated features of human acute myeloid leukemia. Oncogene. 42(16):1272-1281

Xia, J., Liu, M., Zhu, C., Liu, S., Ai, L., Ma, D., Zhu, P., Wang, L., Liu, F. (2023) Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Research. 33(6):448-463

Yu, T., Kuang, H., Wu, X., Huang, Y., Wang, J., Wen, Z. (2023) Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia. Science advances. 9:eadf9790

Zhong, D., Jiang, H., Zhou, C., Ahmed, A., Li, H., Wei, X., Lian, Q., Tastemel, M., Xin, H., Ge, M., Zhang, C., Jing, L. (2023) The microbiota regulates hematopoietic stem and progenitor cell development by mediating inflammatory signals in the niche. Cell Reports. 42:112116112116

Biggs, C.M., Cordeiro-Santanach, A., Prykhozhij, S.V., Deveau, A.P., Lin, Y., Del Bel, K.L., Orben, F., Ragotte, R.J., Saferali, A., Mostafavi, S., Dinh, L., Dai, D., Weinacht, K.G., Dobbs, K., Ott de Bruin, L., Sharma, M., Tsai, K., Priatel, J.J., Schreiber, R.A., Rozmus, J., Hosking, M.C., Shopsowitz, K.E., McKinnon, M.L., Vercauteren, S., Seear, M., Notarangelo, L.D., Lynn, F.C., Berman, J.N., Turvey, S.E. (2022) Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation. JCI insight. 7(24):

Dai, Y., Wu, S., Cao, C., Xue, R., Luo, X., Wen, Z., Xu, J. (2022) Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England). 149(16)

Huang, M., Ahmed, A., Wang, W., Wang, X., Ma, C., Jiang, H., Li, W., Jing, L. (2022) Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish. International Journal of Molecular Sciences. 23(7):

Li, Y., Tang, C., Liu, F., Zhu, C., Liu, F., Zhu, P., Wang, L. (2022) DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development (Cambridge, England). 149(10):

Potts, K.S., Cameron, R.C., Metidji, A., Ghazale, N., Wallace, L., Leal-Cervantes, A.I., Palumbo, R., Barajas, J.M., Gupta, V., Aluri, S., Pradhan, K., Myers, J.A., McKinstry, M., Bai, X., Choudhary, G.S., Shastri, A., Verma, A., Obeng, E.A., Bowman, T.V. (2022) Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition. Cell Reports. 41:111825111825

Sun, R., Sun, L., Xie, X., Li, X., Wu, P., Wang, L., Zhu, P. (2022) Single-cell analysis of transcription factor regulatory networks reveals molecular basis for subtype-specific dysregulation in acute myeloid leukemia. Blood science (Baltimore, Md.). 4:65-75

Wang, W., Li, H., Huang, M., Wang, X., Li, W., Qian, X., Jing, L. (2022) Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. Open Biology. 12:220172

Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)

Zhao, S., Zhang, A., Zhu, H., Wen, Z. (2022) The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development (Cambridge, England). 149(19)

Avagyan, S., Weber, M.C., Ma, S., Prasad, M., Mannherz, W.P., Yang, S., Buenrostro, J.D., Zon, L.I. (2021) Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood advances. 5:2673-2686

Cacialli, P., Mahony, C.B., Petzold, T., Bordignon, P., Rougemont, A.L., Bertrand, J.Y. (2021) A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress. Nature communications. 12:4484

Gioacchino, E., Koyunlar, C., Zink, J., de Looper, H., de Jong, M., Dobrzycki, T., Mahony, C.B., Hoogenboezem, R., Bosch, D., van Strien, P.M.H., van Royen, M.E., French, P.J., Bindels, E., Gussinklo, K.J., Monteiro, R., Touw, I.P., de Pater, E. (2021) Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish. Blood advances. 5:2687-2700

Huang, Z., Chen, K., Chi, Y., Jin, H., Li, L., Zhang, W., Xu, J., Zhang, Y. (2021) Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. The Journal of biological chemistry. 296:100272

Mahony, C.B., Cacialli, P., Pasche, C., Monteiro, R., Savvides, S.N., Bertrand, J.Y. (2021) Hapln1b, a central organizer of the extracellular matrix, modulates kit signalling to control developmental haematopoiesis. Blood advances. 5(23):4935-4948

Peña, O.A., Lubin, A., Hockings, C., Rowell, J., Jung, Y., Hoade, Y., Dace, P.E.I., Valdivia, L.E., Tuschl, K., Boiers, C., Virgilio, M., Richardson, S.E., Payne, E.M. (2021) TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling. Blood advances. 5(20):4112-4124

Póvoa, V., Rebelo de Almeida, C., Maia-Gil, M., Sobral, D., Domingues, M., Martinez-Lopez, M., de Almeida Fuzeta, M., Silva, C., Grosso, A.R., Fior, R. (2021) Innate immune evasion revealed in a colorectal zebrafish xenograft model. Nature communications. 12:1156

Rajan, V., Collett, K., Woodside, R., Prykhozhij, S.V., Moksa, M., Carles, A., Wong, M., Liebman, M., Hirst, M., Berman, J.N. (2021) Stress hematopoiesis induces a proliferative advantage in TET2 deficiency. Leukemia. 36(3):809-820

Weinreb, J.T., Ghazale, N., Pradhan, K., Gupta, V., Potts, K.S., Tricomi, B., Daniels, N.J., Padgett, R.A., De Oliveira, S., Verma, A., Bowman, T.V. (2021) Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Developmental Cell. 56(5):627-640.e5

Zizioli, D., Bernardi, S., Varinelli, M., Farina, M., Mignani, L., Bosio, K., Finazzi, D., Monti, E., Polverelli, N., Malagola, M., Borsani, E., Borsani, G., Russo, D. (2021) Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms. Cells. 10(2):

Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202

Doll, L., Aghaallaei, N., Dick, A.M., Welte, K., Skokowa, J., Bajoghli, B. (2020) A zebrafish model for HAX1-associated congenital neutropenia. Haematologica. 106(5):1311-1320

Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738

Fraint, E., Feliz Norberto, M., Bowman, T.V. (2020) A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish. Blood advances. 4:6189-6198

Guo, Y., Cheng, B.Y.L., Wang, D., Ma, A.C.H., He, B.L., Man, T.K., Cheung, M.P.L., Shi, X., Ng, N.K.L., Leung, A.Y.H. (2020) Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Stem Cell Reports. 14(4):575-589

Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696

Jiang, Z., Carlantoni, C., Allanki, S., Ebersberger, I., Stainier, D.Y.R. (2020) Tek/Tie2 is not required for cardiovascular development in zebrafish. Development (Cambridge, England). 147(19):

Kasper, D.M., Hintzen, J., Wu, Y., Ghersi, J.J., Mandl, H.K., Salinas, K.E., Armero, W., He, Z., Sheng, Y., Xie, Y., Heindel, D.W., Park, E.J., Sessa, W.C., Mahal, L.K., Lebrilla, C., Hirschi, K.K., Nicoli, S. (2020) The N-glycome regulates the endothelial-to-hematopoietic transition. Science (New York, N.Y.). 370:1186-1191

Koth, J., Wang, X., Killen, A.C., Stockdale, W.T., Potts, H.G., Jefferson, A., Bonkhofer, F., Riley, P.R., Patient, R.K., Göttgens, B., Mommersteeg, M.T.M. (2020) Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. Development (Cambridge, England). 147(8)

Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52

Li, F.F., Liang, Y.L., Han, X.S., Guan, Y.N., Chen, J., Wu, P., Zhao, X.X., Jing, Q. (2020) ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1. Acta Pharmacologica Sinica. 42(3):414-421

Lundin, V., Sugden, W.W., Theodore, L.N., Sousa, P.M., Han, A., Chou, S., Wrighton, P.J., Cox, A.G., Ingber, D.E., Goessling, W., Daley, G.Q., North, T.E. (2020) YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental Cell. 52(4):446-460.e5

Oh, C.K., Kang, J.W., Lee, Y., Myung, K., Ha, M., Kang, J., Kwon, E.J., Kim, Y., Oh, S.O., Heo, H.J., Kim, S., Kim, Y.H. (2020) Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish. International Journal of Molecular Sciences. 21(9):

Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366

Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008

Bonkhofer, F., Rispoli, R., Pinheiro, P., Krecsmarik, M., Schneider-Swales, J., Tsang, I.H.C., de Bruijn, M., Monteiro, R., Peterkin, T., Patient, R. (2019) Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nature communications. 10:3577

Ghersi, J.J., Mahony, C.B., Bertrand, J.Y. (2019) bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish. Development (Cambridge, England). 146(6):

Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730

Han, L., Kong, H., Liu, F., Li, X., Zhang, S., Zhang, X., Wu, Y., Yang, H., Zhang, A., Liu, K. (2019) Protective Effect and Mechanisms of New Gelatin on Chemotherapy-Induced Hematopoietic Injury Zebrafish Model. Evidence-based complementary and alternative medicine : eCAM. 2019:8918943

Liu, Z., Tu, H., Kang, Y., Xue, Y., Ma, D., Zhao, C., Li, H., Wang, L., Liu, F. (2019) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature communications. 10:1839

Rho, S.S., Kobayashi, I., Oguri-Nakamura, E., Ando, K., Fujiwara, M., Kamimura, N., Hirata, H., Iida, A., Iwai, Y., Mochizuki, N., Fukuhara, S. (2019) Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Developmental Cell. 49(5):681-696.e6

Tie, R., Li, H., Cai, S., Liang, Z., Shan, W., Wang, B., Tan, Y., Zheng, W., Huang, H. (2019) Interleukin-6 signaling regulates hematopoietic stem cell emergence. Experimental & molecular medicine. 51:1-12

Xie, Y., Gao, L., Xu, C., Chu, L., Gao, L., Wu, R., Liu, Y., Liu, T., Sun, X.J., Ren, R., Tang, J., Zheng, Y., Zhou, Y., Shen, S. (2019) ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 105(4):925-936

Yang, F., Hu, H., Liu, Y., Shao, M., Shao, C., Gong, Y. (2019) Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death & Disease. 10:388

Berrun, A., Harris, E., Stachura, D.L. (2018) Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafish. PLoS One. 13:e0196872

Cai, P., Mao, X., Zhao, J., Luo, L. (2018) Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochemical and Biophysical Research Communications. 497(2):776-782

Dobrzycki, T., Krecsmarik, M., Bonkhofer, F., Patient, R., Monteiro, R. (2018) An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation.. Biology Open. 7(4)

He, S., Chen, J., Jiang, Y., Wu, Y., Zhu, L., Jin, W., Zhao, C., Yu, T., Wang, T., Wu, S., Lin, X., Qu, J.Y., Wen, Z., Zhang, W., Xu, J. (2018) Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. eLIFE. 7

Lahvic, J.L., Ammerman, M., Li, P., Blair, M.C., Stillman, E.R., Fast, E.M., Robertson, A.L., Christodoulou, C., Perlin, J.R., Yang, S., Chiang, N., Norris, P.C., Daily, M.L., Redfield, S.E., Chan, I.T., Chatrizeh, M., Chase, M.E., Weis, O., Zhou, Y., Serhan, C.N., Zon, L.I. (2018) Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proceedings of the National Academy of Sciences of the United States of America. 115(37):9252-9257

Li, D., Xue, W., Li, M., Dong, M., Wang, J., Wang, X., Li, X., Chen, K., Zhang, W., Wu, S., Zhang, Y., Gao, L., Chen, Y., Chen, J., Zhou, B.O., Zhou, Y., Yao, X., Li, L., Wu, D., Pan, W. (2018) VCAM-1⁺ macrophages guide the homing of HSPCs to a vascular niche. Nature. 564(7734):119-124

Mahony, C.B., Pasche, C., Bertrand, J.Y. (2018) Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Stem Cell Reports. 10(6):1920-1934

Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R.I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J.D., Klaeylé, L., Langa, X., Beckmann, C.C.A., Wlodarski, M.W., Müller, P., Van Essen, D., Rambold, A., Kapp, F.G., Mione, M., Buescher, J.M., Pearce, E.L., Polyzos, A., Trompouki, E. (2018) A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature communications. 9:3090

Yu, S., Jiang, T., Jia, D., Han, Y., Liu, F., Huang, Y., Qu, Z., Zhao, Y., Tu, J., Lv, Y., Li, J., Hu, X., Lu, Z., Han, S., Qin, Y., Liu, X., Xie, S., Wang, Q.K., Tang, Z., Luo, D., Liu, M. (2018) BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 133(8):805-815

Zhong, Y., Ye, Q., Chen, C., Wang, M., Wang, H. (2018) Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish. Nucleic acids research. 46(7):3382-3399

Athanasiadis, E.I., Botthof, J.G., Andres, H., Ferreira, L., Lio, P., Cvejic, A. (2017) Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Nature communications. 8:2045

Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467

Dunn, E.M., Billquist, E.J., VanderStoep, A.L., Bax, P.G., Westrate, L.M., McLellan, L.K., Peterson, S.C., MacKeigan, J.P., Putzke, A.P. (2017) Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development. Biology. 6(4)

Gau, P., Curtright, A., Condon, L., Raible, D.W., Dhaka, A. (2017) An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish. PLoS Genetics. 13:e1006884

Goldman, J.A., Kuzu, G., Lee, N., Karasik, J., Gemberling, M., Foglia, M.J., Karra, R., Dickson, A.L., Sun, F., Tolstorukov, M.Y., Poss, K.D. (2017) Resolving Heart Regeneration by Replacement Histone Profiling. Developmental Cell. 40:392-404.e5

Keightley, M.C., Carradice, D.P., Layton, J.E., Pase, L., Bertrand, J.Y., Wittig, J.G., Dakic, A., Badrock, A.P., Cole, N.J., Traver, D., Nutt, S.L., McCoey, J., Buckle, A.M., Heath, J.K., Lieschke, G.J. (2017) The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nature communications. 8:14911

Lim, S.E., Esain, V., Kwan, W., Theodore, L.N., Cortes, M., Frost, I.M., Liu, S.Y., North, T.E. (2017) HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology. 46:83-95.e6

Lu, J.W., Hsieh, M.S., Hou, H.A., Chen, C.Y., Tien, H.F., Lin, L.I. (2017) Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood cancer journal. 7:e593

Place, E.S., Smith, J.C. (2017) Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes. PLoS One. 12:e0171143

Tian, Y., Xu, J., Feng, S., He, S., Zhao, S., Zhu, L., Jin, W., Dai, Y., Luo, L., Qu, J.Y., Wen, Z. (2017) The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. The Journal of experimental medicine. 214(11):3347-3360

Wang, L., Wang, X., Wang, L., Yousaf, M., Li, J., Zuo, M., Yang, Z., Gou, D., Bao, B., Li, L., Xiang, N., Jia, H., Xu, C., Chen, Q., Wang, Q.K. (2017) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1):183-194

Zhang, C., Chen, Y., Sun, B., Wang, L., Yang, Y., Ma, D., Lv, J., Heng, J., Ding, Y., Xue, Y., Lu, X., Xiao, W., Yang, Y.G., Liu, F. (2017) m⁶A modulates haematopoietic stem and progenitor cell specification.. Nature. 549(7671):273-276

Chen, J., He, J., Li, L., Yang, D., Luo, L. (2016) Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports. 6:26608

Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. (2016) Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43(10):593-600

Gao, X., Wu, T., Johnson, K.D., Lahvic, J.L., Ranheim, E.A., Zon, L.I., Bresnick, E.H. (2016) GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 6(3):368-82

Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606

Hou, Y., Sheng, Z., Mao, X., Li, C., Chen, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2016) Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue. Scientific Reports. 6:36853

Kwan, W., Cortes, M., Frost, I., Esain, V., Theodore, L.N., Liu, S.Y., Budrow, N., Goessling, W., North, T.E. (2016) The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell. 19:370-82

Li, R.A., Traver, D., Matthes, T., Bertrand, J.Y. (2016) Ndrg1b and fam49ab modulate the PTEN pathway to control T cell lymphopoiesis in the zebrafish. Blood. 128(26):3052-3060

Mahony, C.B., Fish, R.J., Pasche, C., Bertrand, J.Y. (2016) tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 128(10):1336-45

Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70

Svoboda, O., Stachura, D.L., Machonova, O., Zon, L.I., Traver, D., Bartunek, P. (2016) Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nature Protocols. 11:1007-1020

Wan, Y., Zhang, Q., Zhang, Z., Song, B., Wang, X., Zhang, Y., Jia, Q., Cheng, T., Zhu, X., Leung, A.Y., Yuan, W., Jia, H., Fang, X. (2016) Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. BMC Medical Genomics. 9:13

Yang, Q., Liu, X., Zhou, T., Cook, J., Nguyen, K., Bai, X. (2016) RNA polymerase II pausing differentially regulates signaling pathway genes to control hematopoietic stem cell emergence in zebrafish. Blood. 128(13):1701-10

Anderson, H., Patch, T.C., Reddy, P.N., Hagedorn, E.J., Kim, P.G., Soltis, K.A., Chen, M.J., Tamplin, O.J., Frye, M., MacLean, G.A., Hübner, K., Bauer, D.E., Kanki, J.P., Vogin, G., Huston, N.C., Nguyen, M., Fujiwara, Y., Paw, B.H., Vestweber, D., Zon, L.I., Orkin, S.H., Daley, G.Q., Shah, D.I. (2015) Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 126(26):2811-20

Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61

Deveau, A.P., Forrester, A.M., Coombs, A.J., Wagner, G.S., Grabher, C., Chute, I.C., Léger, D., Mingay, M., Alexe, G., Rajan, V., Liwski, R., Hirst, M., Steigmaier, K., Lewis, S.M., Look, A.T., Berman, J.N. (2015) Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98-HOXA9-induced myeloid disease. Leukemia. 29(10):2086-97

Gao, L., Li, D., Ma, K., Zhang, W., Xu, T., Fu, C., Jing, C., Jia, X., Wu, S., Sun, X., Dong, M., Deng, M., Chen, Y., Zhu, W., Peng, J., Wan, F., Zhou, Y., Zon, L.I., Pan, W. (2015) TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genetics. 11:e1005346

Jang, I.H., Lu, Y.F., Zhao, L., Wenzel, P.L., Kume, T., Datta, S.M., Arora, N., Guiu, J., Lagha, M., Kim, P.G., Do, E.K., Kim, J.H., Schlaeger, T.M., Zon, L.I., Bigas, A., Burns, C.E., Daley, G.Q. (2015) Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 125(9):1418-26

Jing, L., Tamplin, O.J., Chen, M.J., Deng, Q., Patterson, S., Kim, P.G., Durand, E.M., McNeil, A., Green, J.M., Matsuura, S., Ablain, J., Brandt, M.K., Schlaeger, T.M., Huttenlocher, A., Daley, G.Q., Ravid, K., Zon, L.I. (2015) Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. The Journal of experimental medicine. 212(5):649-63

Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2015) Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 523:468-71

Liu, X., Jia, X., Yuan, H., Ma, K., Chen, Y., Jin, Y., Deng, M., Pan, W., Chen, S., Chen, Z., de The, H., Zon, L.I., Zhou, Y., Zhou, J., Zhu, J. (2015) DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Journal of Hematology & Oncology. 8:15

Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611

Rasighaemi, P., Onnebo, S.M., Liongue, C., Ward, A.C. (2015) ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish. Haematologica. 100(1):23-31

Shen, L., Zhu, J., Chen, F., Lin, W., Cai, J., Zhong, J., Zhong, H. (2015) RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC cancer. 15:970

Wang, S., He, Q., Ma, D., Xue, Y., Liu, F. (2015) Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Developmental Cell. 34(6):621-31

Yang, R., Yan, S., Zhu, X., Li, C.Y., Liu, Z., Xiong, J.W. (2015) Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish. Experimental hematology. 43(4):331-341.e8

Alcaraz-Pérez, F., García-Castillo, J., García-Moreno, D., López-Muñoz, A., Anchelin, M., Angosto, D., Zon, L.I., Mulero, V., and Cayuela, M.L. (2014) A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nature communications. 5:3228

Bu, Y., Su, F., Wang, X., Gao, H., Lei, L., Chang, N., Wu, Q., Hu, K., Zhu, X., Chang, Z., Meng, K., Xiong, J.W. (2014) Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. Journal of Cell Science. 127(Pt 12):2761-70

Chen, L.T., Liang, W.X., Chen, S., Li, R.K., Tan, J.L., Xu, P.F., Luo, L.F., Wang, L., Yu, S.H., Meng, G., Li, K.K., Liu, T.X., Chen, Z., Chen, S.J. (2014) Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Nature communications. 5:3811

Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002

Iwanami, N. (2014) Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency. Experimental hematology. 42(8):697-706

Kobayashi, I., Kobayashi-Sun, J., Kim, A.D., Pouget, C., Fujita, N., Suda, T., Traver, D. (2014) Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 512(7514):319-23

Lewis, R.S., Noor, S.M., Fraser, F.W., Sertori, R., Liongue, C., Ward, A.C. (2014) Regulation of Embryonic Hematopoiesis by a Cytokine-Inducible SH2 Domain Homolog in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 192(12):5739-48

Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I.M., Yzaguirre, A.D., Cai, X., Cortes, M., Maijenburg, M.W., Tober, J., Dzierzak, E., Orkin, S.H., Tan, K., North, T.E., Speck, N.A. (2014) Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28(23):2597-612

Marsman, J., O'Neill, A.C., Kao, B.R., Rhodes, J.M., Meier, M., Antony, J., Mönnich, M., and Horsfield, J.A. (2014) Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et biophysica acta. Gene regulatory mechanisms. 1839(1):50-61

Nah, G.S., Lim, Z.W., Tay, B.H., Osato, M., Venkatesh, B. (2014) Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii). PLoS One. 9:e93816

Pimtong, W., Datta, M., Ulrich, A.M., Rhodes, J. (2014) Drl.3 governs primitive hematopoiesis in zebrafish. Scientific Reports. 4:5791

Sawamiphak, S., Kontarakis, Z., Stainier, D.Y. (2014) Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence. Developmental Cell. 31:640-653

Song, B., Zhang, Q., Zhang, Z., Wan, Y., Jia, Q., Wang, X., Zhu, X., Leung, A.Y., Cheng, T., Fang, X., Yuan, W., Jia, H. (2014) Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency. BMC Genomics. 15:759

Wei, Y., Ma, D., Gao, Y., Zhang, C., Wang, L., Liu, F. (2014) Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood. 124(10):1578-85

Amali, A.A., Sie, L., Winkler, C., and Featherstone, M. (2013) Zebrafish hoxd4a Acts Upstream of meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis. PLoS One. 8(3):e58857

Cooney, J.D., Hildick-Smith, G.J., Shafizadeh, E., McBride, P.F., Carroll, K.J., Anderson, H., Shaw, G.C., Tamplin, O.J., Branco, D.S., Dalton, A.J., Shah, D.I., Wong, C., Gallagher, P.G., Zon, L.I., North, T.E., and Paw, B.H. (2013) Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology. 373(2):431-441

Hirabayashi, R., Hozumi, S., Higashijima, S.I., and Kikuchi, Y. (2013) Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish. Stem cells and development. 22(18):2532-42

Jagannathan-Bogdan, M., and Zon, L.I. (2013) Hematopoiesis. Development (Cambridge, England). 140(12):2463-2467

Keightley, M.C., Crowhurst, M.O., Layton, J.E., Beilharz, T., Markmiller, S., Varma, S., Hogan, B.M., de Jong-Curtain, T.A., Heath, J.K., and Lieschke, G.J. (2013) In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. FEBS letters. 587(14):2150-2157

Kramer, J., Granier, C.J., Davis, S., Piso, K., Hand, J., Rabson, A.B., and Sabaawy, H.E. (2013) PDCD2 controls hematopoietic stem cell differentiation during development. Stem cells and development. 22(1):58-72

Ren, C.G., Wang, L., Jia, X.E., Liu, Y.J., Dong, Z.W., Jin, Y., Chen, Y., Deng, M., Zhou, Y., Zhou, Y., Ren, R.B., Pan, W.J., and Liu, T.X. (2013) Activated N-Ras signaling regulates arterial-venous specification in zebrafish. Journal of Hematology & Oncology. 6:34

Stachura, D.L., Svoboda, O., Campbell, C.A., Espín-Palazón, R., Lau, R.P., Zon, L.I., Bartunek, P., and Traver, D. (2013) The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 122(24):3918-28

Wang, S., Yin, J., Chen, D., Nie, F., Song, X., Fei, C., Miao, H., Jing, C., Ma, W., Wang, L., Xie, S., Li, C., Zeng, R., Pan, W., Hao, X., and Li, L. (2013) Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nature Chemical Biology. 9(9):579-85

Zhen, F., Lan, Y., Yan, B., Zhang, W., and Wen, Z. (2013) Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. Development (Cambridge, England). 140(19):3977-3985

Da'as, S.I., Coombs, A.J., Balci, T.B., Grondin, C.A., Ferrando, A.A., and Berman, J.N. (2012) The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 119(15):3585-3594

Hall, C.J., Flores, M.V., Oehlers, S.H., Sanderson, L.E., Lam, E.Y., Crosier, K.E., and Crosier, P.S. (2012) Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide. Cell Stem Cell. 10(2):198-209

Li, L., Yan, B., Shi, Y.Q., Zhang, W.Q., and Wen, Z.L. (2012) Live imaging reveals differing roles of macrophages and neutrophils during Zebrafish tail fin regeneration. The Journal of biological chemistry. 287(30):25353-25360

McKinney-Freeman, S., Cahan, P., Li, H., Lacadie, S.A., Huang, H.T., Curran, M., Loewer, S., Naveiras, O., Kathrein, K.L., Konantz, M., Langdon, E.M., Lengerke, C., Zon, L.I., Collins, J.J., and Daley, G.Q. (2012) The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 11(5):701-714

Torregroza, I., Holtzinger, A., Mendelson, K., Liu, T.C., Hla, T., and Evans, T. (2012) Regulation of a Vascular Plexus by gata4 Is Mediated in Zebrafish through the Chemokine sdf1a. PLoS One. 7(10):e46844

Wilkinson, R.N., Koudijs, M.J., Patient, R.K., Ingham, P.W., Schulte-Merker, S., and van Eeden, F.J. (2012) Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood. 120(2):477-488

Zhang, Y., Morimoto, K., Danilova, N., Zhang, B., and Lin, S. (2012) Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing. PLoS One. 7(1):e30188

Clements, W.K., Kim, A.D., Ong, K.G., Moore, J.C., Lawson, N.D., and Traver, D. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 474(7350):220-224

Keightley, M.C., Layton, J.E., Hayman, J.W., Heath, J.K., and Lieschke, G.J. (2011) Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One. 6(8):e23845

Monteiro, R., Pouget, C., and Patient, R. (2011) The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. The EMBO journal. 30(6):1093-1103

Oehlers, S.H., Flores, M.V., Hall, C.J., Swift, S., Crosier, K.E., and Crosier, P.S. (2011) The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Disease models & mechanisms. 4(6):832-41

Simões, F.C., Peterkin, T., and Patient, R. (2011) Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development (Cambridge, England). 138(15):3235-3245

Wang, L., Zhang, P., Wei, Y., Gao, Y., Patient, R., and Liu, F. (2011) A blood flow-dependent klf2a-NO signalling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 118(15):4102-10

Bertrand, J.Y., Chi, N.C., Santoso, B., Teng, S., Stainier, D.Y., and Traver, D. (2010) Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 464(7285):108-111

Danilova, N., Kumagai, A., and Lin, J. (2010) p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes. PLoS One. 5(12):e15938

Huang, C., Gu, S., Yu, P., Yu, F., Feng, C., Gao, N., and Du, J. (2010) Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Developmental Biology. 339(1):89-100

Kulkeaw, K., Ishitani, T., Kanemaru, T., Fucharoen, S., and Sugiyama, D. (2010) Cold exposure down-regulates zebrafish hematopoiesis. Biochemical and Biophysical Research Communications. 394(4):859-864

Ma, A.C., Chung, M.I., Liang, R., and Leung, A.Y. (2010) A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia. 24(12):2090-2099

Rowlinson, J.M., and Gering, M. (2010) Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood. 116(12):2046-2056

Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782

Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., and Zon, L.I. (2009) Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136(6):1136-1147

Kitaguchi, T., Kawakami, K., and Kawahara, A. (2009) Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis. Mechanisms of Development. 126(5-6):314-323

North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I. (2009) Hematopoietic stem cell development is dependent on blood flow. Cell. 137(4):736-748

Peterkin, T., Gibson, A., and Patient, R. (2009) Common genetic control of haemangioblast and cardiac development in zebrafish. Development (Cambridge, England). 136(9):1465-1474

Bertrand, J.Y., Kim, A.D., Teng, S., and Traver, D. (2008) CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development (Cambridge, England). 135(10):1853-1862

Kissa, K., Murayama, E., Zapata, A., Cortes, A., Perret, E., Machu, C., and Herbomel, P. (2008) Live imaging of emerging hematopoietic stem cells and early thymus colonization. Blood. 111(3):1147-1156

Yeh, J.R., Munson, K.M., Chao, Y.L., Peterson, Q.P., MacRae, C.A., and Peterson, R.T. (2008) AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (Cambridge, England). 135(2):401-410

Gardiner, M.R., Gongora, M.M., Grimmond, S.M., and Perkins, A.C. (2007) A global role for zebrafish klf4 in embryonic erythropoiesis. Mechanisms of Development. 124(9-10):762-774

McReynolds, L.J., Gupta, S., Figueroa, M.E., Mullins, M.C., and Evans, T. (2007) Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 110(12):3881-3890

Patterson, L.J., Gering, M., Eckfeldt, C.E., Green, A.R., Verfaillie, C.M., Ekker, S.C., and Patient, R. (2007) The transcription factors, Scl and Lmo2, act together during development of the hemangioblast in zebrafish. Blood. 109(6):2389-2398

Zhang, X.Y., and Rodaway, A.R. (2007) SCL-GFP transgenic zebrafish: In vivo imaging of blood and endothelial development and identification of the initial site of definitive hematopoiesis. Developmental Biology. 307(2):179-194

Flores, M.V., Lam, E.Y., Crosier, P., and Crosier, K. (2006) A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(11):3166-3176

Li, X., Xiong, J.W., Shelley, C.S., Park, H., and Arnaout, M.A. (2006) The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development (Cambridge, England). 133(18):3641-3650

Murayama, E., Kissa, K., Zapata, A., Mordelet, E., Briolat, V., Lin, H.F., Handin, R.I., and Herbomel, P. (2006) Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development. Immunity. 25(6):963-975

Burns, C.E., Traver, D., Mayhall, E., Shepard, J.L., and Zon, L.I. (2005) Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes & Development. 19(19):2331-2342

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Developmental Cell. 8(1):109-116

Hsia, N., and Zon, L.I. (2005) Transcriptional regulation of hematopoietic stem cell development in zebrafish. Experimental hematology. 33(9):1007-1014

Rhodes, J., Hagen, A., Hsu, K., Deng, M., Liu, T.X., Look, A.T., and Kanki, J.P. (2005) Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Developmental Cell. 8(1):97-108

Davidson, A.J., and Zon, L.I. (2004) The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene. 23(43):7233-7246

Gering, M., Yamada, Y., Rabbitts, T.H., and Patient, R.K. (2003) Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development (Cambridge, England). 130:6287-6199

Burns, C.E., DeBlasio, T., Zhou, Y., Zhang, J., Zon, L., and Nimer, S.D. (2002) Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Experimental hematology. 30(12):1381-1389

Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development (Cambridge, England). 129(8):2015-2030