Gene

runx1

ID
ZDB-GENE-000605-1
Name
RUNX family transcription factor 1
Symbol
runx1 Nomenclature History
Previous Names
  • runx1a (1)
  • runxa
  • aml1 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle tissue regeneration; positive regulation of collagen biosynthetic process; and regulation of connective tissue replacement. Acts upstream of or within several processes, including endothelial to hematopoietic transition; hemopoiesis; and regulation of gene expression. Predicted to be located in nucleus. Is expressed in several structures, including cranial ganglion; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
358 figures from 168 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With runx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid 601626
Platelet disorder, familial, with associated myeloid malignancy 601399
Associated With runx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013524 Runt domain
Domain IPR013711 Runx, C-terminal domain
Family IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
Family IPR016554 Runt-related transcription factor RUNX
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR027384 Runx, central domain superfamily
Domain Details Per Protein
Protein Length Acute myeloid leukemia 1 protein (AML1)/Runt p53-like transcription factor, DNA-binding p53/RUNT-type transcription factor, DNA-binding domain superfamily Runt domain Runt-related transcription factor RUNX Runx, central domain superfamily Runx, C-terminal domain
UniProtKB:Q9DGB8 451
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations