PUBLICATION
Zebrafish as a model for myelopoiesis during embryogenesis
- Authors
- Berman, J.N., Kanki, J.P., and Look, A.T.
- ID
- ZDB-PUB-050907-14
- Date
- 2005
- Source
- Experimental hematology 33(9): 997-1006 (Journal)
- Registered Authors
- Berman, Jason, Kanki, John, Look, A. Thomas
- Keywords
- none
- MeSH Terms
-
- Animals
- Embryonic Development/genetics*
- Embryonic Development/physiology
- Gene Expression Regulation, Developmental
- Hematopoiesis/genetics
- Hematopoiesis/physiology
- Models, Animal
- Myelopoiesis/genetics
- Myelopoiesis/physiology*
- Zebrafish
- PubMed
- 16140147 Full text @ Exp. Hematol.
Citation
Berman, J.N., Kanki, J.P., and Look, A.T. (2005) Zebrafish as a model for myelopoiesis during embryogenesis. Experimental hematology. 33(9):997-1006.
Abstract
Zebrafish produce nearly identical hematopoeitic cell lineages to those found in mammals and other higher vertebrates. As in mammals, blood cell development proceeds in distinct waves, constituting embryonic (primitive) and adult (definitive) hematopoiesis. The conservation of genes such as scl, pu.1, c/ebpalpha, mpo, l-plastin, and lysozyme C in myelopoiesis and the corresponding expression patterns in zebrafish suggests that shared genetic pathways regulate this complex developmental process. In the zebrafish model system, experimental approaches have been applied, including RNA in situ hybridzation, morpholino injections, and the analysis of mutant and transgenic fish lines, leading to improved understanding of the regulation in vivo of key molecular pathways with conserved roles in vertebrate myelopoiesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping