ZFIN

ZFIN ID: ZDB-GENE-000526-1

ZFIN ID: ZDB-GENE-000526-1

CITATIONS (173 total)

Gene Name:	hes-related family bHLH transcription factor with YRPW motif 2
Gene Symbol:	hey2

Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
Aday, A.W., Zhu, L.J., Lakshmanan, A., Wang, J., and Lawson, N.D. (2011) Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites. Developmental Biology. 357(2):450-62
Aranguren, X.L., Beerens, M., Vandevelde, W., Dewerchin, M., Carmeliet, P., and Luttun, A. (2011) Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. Biochemical and Biophysical Research Communications. 410(1):121-6
Baek, K.I., Packard, R.R., Hsu, J.J., Saffari, A., Ma, Z., Luu, A.P., Pietersen, A., Yen, H., Ren, B., Ding, Y., Sioutas, C., Li, R., Hsiai, T.K. (2017) Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxidants & redox signaling. 28(13):1209-1223
Bayliss, P.E., Bellavance, K.L., Whitehead, G.G., Abrams, J.M., Aegerter, S., Robbins, H.S., Cowan, D.B., Keating, M.T., O'reilly, T., Wood, J.M., Roberts, T.M., and Chan, J. (2006) Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2(5):265-273
Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., and MacRae, C.A. (2012) In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signaling. Cardiovascular research. 93(3):463-470
Bussmann, J., Bakkers, J., and Schulte-Merker, S. (2007) Early Endocardial Morphogenesis Requires Scl/Tal1. PLoS Genetics. 3(8):e140
Cade, L., Reyon, D., Hwang, W.Y., Tsai, S.Q., Patel, S., Khayter, C., Joung, J.K., Sander, J.D., Peterson, R.T., and Yeh, J.R. (2012) Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic acids research. 40(16):8001-8010
Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
Carney, S.A., Chen, J., Burns, C.G., Xiong, K.M., Peterson, R.E., and Heideman, W. (2006) Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Molecular pharmacology. 70(2):549-561
Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53
Cermenati, S., Moleri, S., Cimbro, S., Corti, P., Del Giacco, L., Amodeo, R., Dejana, E., Koopman, P., Cotelli, F., and Beltrame, M. (2008) Sox18 and Sox7 play redundant roles in vascular development. Blood. 111(5):2657-2666
Chen, D., Li, L., Tu, X., Yin, Z., and Wang, Q. (2013) Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation during embryogenesis. Human molecular genetics. 22(5):963-976
Chen, I.H., Wang, H.H., Hsieh, Y.S., Huang, W.C., Yeh, H.I., and Chuang, Y.J. (2013) PRSS23 is essential for the Snail-dependent endothelial to mesenchymal transition during valvulogenesis in zebrafish. Cardiovascular research. 97(3):443-453
Chen, J., Li, X., Ni, R., Chen, Q., Yang, Q., He, J., Luo, L. (2021) Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell. 56(22):3115-3127.e6
Chen, K., Fan, Y., Gu, J., Han, Z., Zeng, H., Mao, C., Wang, C. (2020) In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether. Drug design, development and therapy. 14:3069-3078
Chen, K., Wang, C., Fan, Y., Gu, J., Han, Z., Wang, Y., Gao, L., Zeng, H. (2018) Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity. Experimental and Therapeutic Medicine. 16:4562-4568
Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047
Chiang, I.K., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Hermkens, D., Lesieur, E., Liu, K., Ratnayaka, I., Corada, M., Bou-Gharios, G., Carroll, J., Dejana, E., Schulte-Merker, S., Hogan, B., Beltrame, M., De Val, S., Francois, M. (2017) SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development (Cambridge, England). 144(14):2629-2639
Chou, C.W., Hsu, H.C., Quek, S.I., Chan, W.K., and Liu, Y.W. (2010) Arterial and venous vessels are required for modulating developmental relocalization and laterality of the interrenal tissue in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):1995-2004
Chun, C.Z., Kaur, S., Samant, G.V., Wang, L., Pramanik, K., Garnaas, M.K., Li, K., Field, L., Mukhopadhyay, D., and Ramchandran, R. (2009) Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. Blood. 113(5):1192-1199
Chun, C.Z., Remadevi, I., Schupp, M.O., Samant, G.V., Pramanik, K., Wilkinson, G.A., and Ramchandran, R. (2011) Fli+ etsrp+ Hemato-Vascular Progenitor Cells Proliferate at the Lateral Plate Mesoderm during Vasculogenesis in Zebrafish. PLoS One. 6(2):e14732
Coxam, B., Neyt, C., Grassini, D.R., Le Guen, L., Smith, K.A., Schulte-Merker, S., Hogan, B.M. (2015) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(1):1-9
da Silva, A.R., Gunawan, F., Boezio, G.L.M., Faure, E., Théron, A., Avierinos, J.F., Lim, S., Jha, S.G., Ramadass, R., Guenther, S., Looso, M., Zaffran, S., Juan, T., Stainier, D.Y.R. (2024) egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. Science advances. 10:eadl0633
De Angelis, J.E., Lagendijk, A.K., Chen, H., Tromp, A., Bower, N.I., Tunny, K.A., Brooks, A.J., Bakkers, J., Francois, M., Yap, A.S., Simons, C., Wicking, C., Hogan, B.M., Smith, K.A. (2017) Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Developmental Cell. 40:123-136
Delvaeye, M., Devriese, A., Zwerts, F., Betz, I., Moons, M., Autiero, M., and Conway, E.M. (2009) Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis. BMC Developmental Biology. 9:25
Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
Dogra, D., Ahuja, S., Kim, H.T., Rasouli, S.J., Stainier, D.Y.R., Reischauer, S. (2017) Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair. Nature communications. 8:1902
Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
Dyer, C., Linker, C., Graham, A., Knight, R. (2014) Specification of sensory neurons occurs through diverse developmental programs functioning in the brain and spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(11):1429-39
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
Esser, J.S., Steiner, R.E., Deckler, M., Schmitt, H., Engert, B., Link, S., Charlet, A., Patterson, C., Bode, C., Zhou, Q., Moser, M. (2018) Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. The FEBS journal. 285(8):1419-1436
Feng, L., Hernandez, R.E., Waxman, J.S., Yelon, D., and Moens, C.B. (2010) Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Developmental Biology. 338(1):1-14
Fischer, A. and Gessler, M. (2003) Hey genes in cardiovascular development. Trends Cardiovasc.. 13(6):221-226
Foley, J.E., Yeh, J.R., Maeder, M.L., Reyon, D., Sander, J.D., Peterson, R.T., and Joung, J.K. (2009) Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 4(2):e4348
Gajewski, M. and Voolstra, C. (2002) Comparative analysis of somitogenesis related genes of the hairy/Enhancer of split class in Fugu and zebrafish. BMC Genomics. 3(1):21
Garnaas, M.K., Moodie, K.L., Liu, M.L., Samant, G.V., Li, K., Marx, R., Baraban, J.M., Horowitz, A., and Ramchandran, R. (2008) Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo. Circulation research. 103(7):710-716
Ghanta, K.S., Chen, Z., Mir, A., Dokshin, G.A., Krishnamurthy, P.M., Yoon, Y., Gallant, J., Xu, P., Zhang, X.O., Ozturk, A.R., Shin, M., Idrizi, F., Liu, P., Gneid, H., Edraki, A., Lawson, N.D., Rivera-Pérez, J.A., Sontheimer, E., Watts, J.K., Mello, C.C. (2021) 5' modifications improve potency and efficacy of DNA donors for precision genome editing. eLIFE. 10:
Ghosh, T.K., Aparicio-Sánchez, J.J., Buxton, S., Ketley, A., Mohamed, T., Rutland, C.S., Loughna, S., David Brook, J. (2017) Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. Journal of Molecular and Cellular Cardiology. 114:185-198
Gibb, N., Lazic, S., Yuan, X., Deshwar, A.R., Leslie, M., Wilson, M.D., Scott, I.C. (2018) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development (Cambridge, England). 145(22):
Goi, M., Childs, S.J. (2016) Patterning Mechanisms of the Sub-Intestinal Venous Plexus in Zebrafish. Developmental Biology. 409(1):114-28
Gore, A.V., Swift, M.R., Cha, Y.R., Lo, B., McKinney, M.C., Li, W., Castranova, D., Davis, A., Mukouyama, Y.S., and Weinstein, B.M. (2011) Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (Cambridge, England). 138(22):4875-4886
Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606
Gray, C., Packham, I.M., Wurmser, F., Eastley, N.C., Hellewell, P.G., Ingham, P.W., Crossman, D.C., and Chico, T.J. (2007) Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 27(10):2135-2141
Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):
Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
Guiu, J., Bergen, D.J., De Pater, E., Islam, A.B., Ayllón, V., Gama-Norton, L., Ruiz-Herguido, C., González, J., López-Bigas, N., Menendez, P., Dzierzak, E., Espinosa, L., Bigas, A. (2014) Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. The Journal of experimental medicine. 211(12):2411-23
Guo, Y., Cheng, B.Y.L., Wang, D., Ma, A.C.H., He, B.L., Man, T.K., Cheung, M.P.L., Shi, X., Ng, N.K.L., Leung, A.Y.H. (2020) Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Stem Cell Reports. 14(4):575-589
Gupta, A., Christensen, R.G., Rayla, A.L., Lakshmanan, A., Stormo, G.D., and Wolfe, S.A. (2012) An optimized two-finger archive for ZFN-mediated gene targeting. Nature Methods. 9(6):588-590
Hashiura, T., Kimura, E., Fujisawa, S., Oikawa, S., Nonaka, S., Kurosaka, D., Hitomi, J. (2017) Live imaging of primary ocular vasculature formation in zebrafish. PLoS One. 12:e0176456
He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 125(7):1098-106
Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696
Heng, J., Shi, B., Zhou, J.Y., Zhang, Y., Ma, D., Yang, Y.G., Liu, F. (2023) Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2212212120e2212212120
Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M., and Stainier, D.Y. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (New York, N.Y.). 326(5950):294-298
Hermans, K., Claes, F., Vandevelde, W., Zheng, W., Geudens, I., Orsenigo, F., De Smet, F., Gjini, E., Anthonis, K., Ren, B., Kerjaschki, D., Autiero, M., Ny, A., Simons, M., Dewerchin, M., Schulte-Merker, S., Dejana, E., Alitalo, K., and Carmeliet, P. (2010) Role of synectin in lymphatic development in zebrafish and frogs. Blood. 116(17):3356-3366
Hermkens, D.M., van Impel, A., Urasaki, A., Bussmann, J., Duckers, H.J., Schulte-Merker, S. (2015) Sox7 controls arterial specification in conjunction with hey2 and efnb2 function. Development (Cambridge, England). 142(9):1695-704
Hirashima, M., and Suda, T. (2006) Differentiation of arterial and venous endothelial cells and vascular morphogenesis. Endothelium : journal of endothelial cell research. 13(2):137-145
Hogan, B.M., Bussmann, J., Wolburg, H., and Schulte-Merker, S. (2008) ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Human molecular genetics. 17(16):2424-2432
Hogan, B.M., Herpers, R., Witte, M., Heloterä, H., Alitalo, K., Duckers, H.J., and Schulte-Merker, S. (2009) Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries. Development (Cambridge, England). 136(23):4001-4009
Hong, C.C., Peterson, Q.P., Hong, J.Y., and Peterson, R.T. (2006) Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Current biology : CB. 16(13):1366-1372
Irimia, M., Tena, J.J., Alexis, M., Fernandez-Miñan, A., Maeso, I., Bogdanovic, O., de la Calle-Mustienes, E., Roy, S.W., Gómez-Skarmeta, J.L., and Fraser, H.B. (2012) Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints. Genome research. 22(12):2356-2367
Iwasaki, R., Tsuge, K., Kishimoto, K., Hayashi, Y., Iwaana, T., Hohjoh, H., Inazumi, T., Kawahara, A., Tsuchiya, S., Sugimoto, Y. (2019) Essential role of prostaglandin E₂ and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis. Scientific Reports. 9:7650
Jia, H., King, I.N., Chopra, S.S., Wan, H., Ni, T.T., Jiang, C., Guan, X., Wells, S., Srivastava, D., and Zhong, T.P. (2007) Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proceedings of the National Academy of Sciences of the United States of America. 104(35):14008-14013
Jin, D., Zhu, D., Fang, Y., Chen, Y., Yu, G., Pan, W., Liu, D., Li, F., Zhong, T.P. (2017) Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. Journal of genetics and genomics = Yi chuan xue bao. 44(10):483-492
Just, S., Berger, I.M., Meder, B., Backs, J., Keller, A., Marquart, S., Frese, K., Patzel, E., Rauch, G.J., Tübingen 2000 Screen Consortium, Katus, H.A., and Rottbauer, W. (2011) Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity. Circulation. 124(3):324-34
Karthik, S., Djukic, T., Kim, J.D., Zuber, B., Makanya, A., Odriozola, A., Hlushchuk, R., Filipovic, N., Jin, S.W., Djonov, V. (2018) Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development. Scientific Reports. 8:9840
Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
Kohli, V., Schumacher, J.A., Desai, S.P., Rehn, K., and Sumanas, S. (2013) Arterial and venous progenitors of the major axial vessels originate at distinct locations. Developmental Cell. 25(2):196-206
Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
Lawson, N.D., Scheer, N., Pham, V.N., Kim, C.-H., Chitnis, A.B., Campos-Ortega, J.A., and Weinstein, B.M. (2001) Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (Cambridge, England). 128(19):3675-3683
Li, B., Chen, K., Liu, F., Zhang, J., Chen, X., Chen, T., Chen, Q., Yao, Y., Hu, W., Wang, L., Wu, Y. (2021) Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase. Frontiers in cardiovascular medicine. 8:724846
Li, Y., Tang, C., Liu, F., Zhu, C., Liu, F., Zhu, P., Wang, L. (2022) DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development (Cambridge, England). 149(10):
Liang, S.T., Chen, J.R., Tsai, J.J., Lai, Y.H., Hsiao, C.D. (2019) Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish. International Journal of Molecular Sciences. 20(15)
Liu, Y.W., and Guo, L. (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Developmental Biology. 297(1):44-58
Liu, Z., Tu, H., Kang, Y., Xue, Y., Ma, D., Zhao, C., Li, H., Wang, L., Liu, F. (2019) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature communications. 10:1839
Lu, T., Zhang, T., Wang, C., Yang, N., Pan, Y.H., Dang, S., Zhang, W. (2019) Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation. Biochemical and Biophysical Research Communications. 521(4):907-913
Luo, H., Zhang, Y., Deng, Y., Li, L., Sheng, Z., Yu, Y., Lin, Y., Chen, X., Feng, P. (2021) Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Frontiers in cell and developmental biology. 9:728821
Ma, J., Gu, Y., Liu, J., Song, J., Zhou, T., Jiang, M., Wen, Y., Guo, X., Zhou, Z., Sha, J., He, J., Hu, Z., Luo, L., Liu, M. (2022) Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cellular and molecular life sciences : CMLS. 80:1919
Mei, J., Liu, S., Li, Z., and Gui, J.F. (2010) Mtmr8 is essential for vasculature development in zebrafish embryos. BMC Developmental Biology. 10:96
Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
Moore, J.C., Sheppard, S., Shestopalov, I.A., Chen, J.K., and Lawson, N. (2013) Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Developmental Biology. 384(1):128-40
Mouillesseaux, K., and Chen, J.N. (2011) Mutation in utp15 Disrupts Vascular Patterning in a p53-Dependent Manner in Zebrafish Embryos. PLoS One. 6(9):e25013
North, T.E. and Zon, L.I. (2003) Modeling human hematopoietic and cardiovascular diseases in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):568-583
Novodvorsky, P., Watson, O., Gray, C., Wilkinson, R.N., Reeve, S., Smythe, C., Beniston, R., Plant, K., Maguire, R., M K Rothman, A., Elworthy, S., van Eeden, F.J., Chico, T.J. (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One. 10:e0141611
Ny, A., Autiero, M., and Carmeliet, P. (2006) Zebrafish and Xenopus tadpoles: Small animal models to study angiogenesis and lymphangiogenesis. Experimental cell research. 312(5):684-693
Olena, A.F., Rao, M.B., Thatcher, E.J., Wu, S.Y., Patton, J.G. (2015) miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development. Developmental Biology. 400(1):72-81
Overman, J., Fontaine, F., Moustaqil, M., Mittal, D., Sierecki, E., Sacilotto, N., Zuegg, J., Robertson, A.A., Holmes, K., Salim, A.A., Mamidyala, S., Butler, M.S., Robinson, A.S., Lesieur, E., Johnston, W., Alexandrov, K., Black, B.L., Hogan, B.M., Val, S., Capon, R.J., Carroll, J.S., Bailey, T.L., Koopman, P., Jauch, R., Smyth, M.J., Cooper, M.A., Gambin, Y., Francois, M. (2017) Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLIFE. 6
Packard, R.R.S., Baek, K.I., Beebe, T., Jen, N., Ding, Y., Shi, F., Fei, P., Kang, B.J., Chen, P.H., Gau, J., Chen, M., Tang, J.Y., Shih, Y.H., Ding, Y., Li, D., Xu, X., Hsiai, T.K. (2017) Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Scientific Reports. 7:8603
Packham, I.M., Gray, C., Heath, P.R., Hellewell, P.G., Ingham, P.W., Crossman, D.C., Milo, M., and Chico, T.J. (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiological Genomics. 38(3):319-327
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Additional Citations (26):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2020) Nomenclature Data Curation (2020). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

Phenotype Annotation (1994-2006) (2006) Mutant Data Curated from Older Literature. ZFIN Historical Data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, C., and Thisse, B. (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Submission and Curation of Mutant and Transgenic Lines. ZFIN Direct Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.