PUBLICATION
In vivo drug discovery in the zebrafish
- Authors
- Zon, L.I., and Peterson, R.T.
- ID
- ZDB-PUB-050203-5
- Date
- 2005
- Source
- Nature reviews. Drug discovery 4(1): 35-44 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Drug Evaluation, Preclinical/methods
- Drug Design*
- Humans
- Zebrafish/embryology
- Zebrafish/physiology*
- Models, Animal*
- Toxicity Tests/methods
- PubMed
- 15688071 Full text @ Nat. Rev. Drug Discov.
Citation
Zon, L.I., and Peterson, R.T. (2005) In vivo drug discovery in the zebrafish. Nature reviews. Drug discovery. 4(1):35-44.
Abstract
The zebrafish has become a widely used model organism because of its fecundity, its morphological and physiological similarity to mammals, the existence of many genomic tools and the ease with which large, phenotype-based screens can be performed. Because of these attributes, the zebrafish might also provide opportunities to accelerate the process of drug discovery. By combining the scale and throughput of in vitro screens with the physiological complexity of animal studies, the zebrafish promises to contribute to several aspects of the drug development process, including target identification, disease modelling, lead discovery and toxicology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping