PUBLICATION
Zebrafish and Xenopus tadpoles: Small animal models to study angiogenesis and lymphangiogenesis
- Authors
- Ny, A., Autiero, M., and Carmeliet, P.
- ID
- ZDB-PUB-051207-4
- Date
- 2006
- Source
- Experimental cell research 312(5): 684-693 (Journal)
- Registered Authors
- Keywords
- Angiogenesis, Lymphangiogenesis, Zebrafish, Xenopus
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian/physiology
- Humans
- Lymphangiogenesis/physiology*
- Models, Animal
- Neovascularization, Physiologic/physiology*
- Research/trends
- Xenopus/embryology
- Xenopus/genetics
- Xenopus/physiology*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/physiology*
- PubMed
- 16309670 Full text @ Exp. Cell Res.
Citation
Ny, A., Autiero, M., and Carmeliet, P. (2006) Zebrafish and Xenopus tadpoles: Small animal models to study angiogenesis and lymphangiogenesis. Experimental cell research. 312(5):684-693.
Abstract
Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable models to rapidly identify and characterize novel genes involved in angiogenesis and lymphangiogenesis-a significant task with a consequent impact on the design of more effective therapeutic strategies. The advantages of these two models will be discussed in the present review.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping