Gene

hey2

ID
ZDB-GENE-000526-1
Name
hes-related family bHLH transcription factor with YRPW motif 2
Symbol
hey2 Nomenclature History
Previous Names
  • gridlock (1)
  • grl (1)
  • Herp2 (1)
  • zgc:136746 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Notch signaling pathway; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on cardiac muscle cell proliferation. Acts upstream of or within circulatory system development and negative regulation of transcription, DNA-templated. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; hematopoietic system; mesoderm; and nervous system. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
69 figures from 55 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hey2 Human Ortholog
No data available
Associated With hey2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003650 Orange domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Orange domain
UniProtKB:Q9I9L0 324
UniProtKB:B3DGE6 324
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations