PUBLICATION
Gridlock, a localized heritable vascular patterning defect in the zebrafish
- Authors
- Weinstein, B.M., Stemple, D.L., Driever, W., and Fishman, M.C.
- ID
- ZDB-PUB-961014-1221
- Date
- 1995
- Source
- Nature medicine 1(11): 1143-1147 (Journal)
- Registered Authors
- Driever, Wolfgang, Fishman, Mark C., Stemple, Derek L., Weinstein, Brant M.
- Keywords
- none
- MeSH Terms
-
- Angiography
- Animals
- Aorta/abnormalities*
- Aorta/embryology
- Aorta, Thoracic/embryology
- Aortic Coarctation*/etiology
- Aortic Coarctation*/genetics
- Blood Circulation
- Genes, Recessive
- Humans
- Mutation*
- Zebrafish/embryology
- Zebrafish/genetics*
- PubMed
- 7584985 Full text @ Nat. Med.
Citation
Weinstein, B.M., Stemple, D.L., Driever, W., and Fishman, M.C. (1995) Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nature medicine. 1(11):1143-1147.
Abstract
We are using the zebrafish, Danio rerio, to identify genes that generate and pattern the vertebrate vasculature. We have isolated a recessive mutation, gridlockm145 (grlm145) in which blood flow to the tail is impeded by a localized vascular defect. Using a novel microangiographic method, we show that the blockade is in the anterior trunk, where the paired lateral dorsal aortae normally merge to form the single midline aorta. Arterial-venous shunts and collateral vessels develop in most mutant embryos, bypassing the lesion and reconstituting caudal blood flow. The grl defect resembles coarctation of the aorta, a human congenital cardiovascular malformation of unknown aetiology, in the location of the lesion and its consequences and in the mutants' dependence on collateral vessels for survival.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping