ZFIN Morpholino: MO1-spi1b

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-spi1b

No data available

Phenotype

Phenotype resulting from MO1-spi1b

Phenotype	Fish	Figures
blood island lacks parts or has fewer parts of type granulocyte, abnormal	WT + MO1-spi1b	Fig. 3, Fig. 5 from Bukrinsky et al., 2009
blood island lacks parts or has fewer parts of type macrophage, abnormal	WT + MO1-spi1b	Fig. 3, Fig. 5 from Bukrinsky et al., 2009
blood island macrophage decreased amount, abnormal	WT + MO1-spi1b	Fig. 1 from Tenor et al., 2015
blood island neutrophil decreased amount, abnormal	nz117Tg + MO1-spi1b	Fig. 1 from Tenor et al., 2015
brain lacks all parts of type microglial cell, abnormal	WT + MO1-spi1b	Fig. 1 from Villani et al., 2019 Fig. 3 from Rossi et al., 2015 Fig. S7 from Flinn et al., 2013

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Phenotype of all Fish created by or utilizing MO1-spi1b

Phenotype	Fish	Conditions	Figures
intermediate cell mass of mesoderm drll.3 expression increased amount, abnormal	AB + MO1-spi1b	standard conditions	Fig. 6 from Pimtong et al., 2014
intermediate cell mass of mesoderm drll.1 expression increased amount, abnormal	AB + MO1-spi1b	standard conditions	Fig. 6 from Pimtong et al., 2014
macrophage absent, abnormal	AB + MO1-spi1b	standard conditions	Fig. 9 from Mathew et al., 2007
neutrophil absent, abnormal	AB + MO1-spi1b	standard conditions	Fig. 9 from Mathew et al., 2007 Fig. 4 from Mathias et al., 2007
phagocytosis decreased occurrence, abnormal	AB + MO1-spi1b	standard conditions	Fig. 1 from van der Vaart et al., 2013

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Citations

Include unpublished citations

El Omar, R., Abdellaoui, N., Coulibaly, S.T., Fontenille, L., Lanza, F., Gachet, C., Freund, J.N., Negroni, M., Kissa, K., Tavian, M. (2024) Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo. Cell Death & Disease. 15:305305
Thrikawala, S.U., Anderson, M.H., Rosowski, E.E. (2024) Glucocorticoids Suppress NF-κB-Mediated Neutrophil Control of Aspergillus fumigatus Hyphal Growth. Journal of immunology (Baltimore, Md. : 1950). 213(7):971-987
Ellett, F., Kacamak, N.I., Alvarez, C.R., Oliveira, E.H.S., Hasturk, H., Paster, B.J., Kantarci, A., Irimia, D. (2023) Fusobacterium nucleatum dissemination by neutrophils. Journal of oral microbiology. 15:22170672217067
Lensen, A., Gomes, M.C., López-Jiménez, A.T., Mostowy, S. (2023) An automated microscopy workflow to study Shigella-neutrophil interactions and antibiotic efficacy in vivo. Disease models & mechanisms. 16(6):
Viana, F., Boucontet, L., Laghi, V., Schator, D., Ibranosyan, M., Jarraud, S., Colucci-Guyon, E., Buchrieser, C. (2023) Hiding in the yolk: A unique feature of Legionella pneumophila infection of zebrafish. PLoS pathogens. 19:e1011375e1011375
Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
Chen, X.K., Kwan, J.S., Wong, G.T., Yi, Z.N., Ma, A.C., Chang, R.C. (2022) Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Experimental & molecular medicine. 54(7):973-987
Demy, D.L., Touret, A.L., Lancino, M., Tauzin, M., Capuana, L., Pierre, C., Herbomel, P. (2022) Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production. Development (Cambridge, England). 149(18):
Forn-Cuní, G., Welvaarts, L., Stel, F.M., van den Hondel, C.J., Arentshorst, M., Ram, A., Meijer, A.H. (2022) Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis. Autophagy. 19(1):324-337
Haraoka, Y., Akieda, Y., Nagai, Y., Mogi, C., Ishitani, T. (2022) Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nature communications. 13:1417

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