Gene

spi1b

ID
ZDB-GENE-980526-164
Name
Spi-1 proto-oncogene b
Symbol
spi1b Nomenclature History
Previous Names
  • pu.1
  • pu1
  • spi1 (1)
  • cb1086 (1)
  • si:by184l24.2
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in myeloid cell differentiation; negative regulation of myeloid cell differentiation; and positive regulation of gene expression. Predicted to localize to nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; trunk; and yolk. Orthologous to human SPI1 (Spi-1 proto-oncogene).
Genome Resources
Note
None
Expression
All Expression Data
191 figures from 127 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 24 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spi1b Human Ortholog
No data available
Associated With spi1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000418 Ets domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Ets domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q78AM8 296
UniProtKB:F1R668 266
UniProtKB:Q8JID4 290
UniProtKB:Q6PHV7 220
UniProtKB:Q6WEE1 297
UniProtKB:Q6WEE0 296
UniProtKB:Q8AW41 265
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-spi1 Rabbit
  • IHC
2
Ab1-spi1 polyclonal IgG Rabbit
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations