ZFIN ID: ZDB-GENE-980526-164
Gene Name: Spi-1 proto-oncogene b
Gene Symbol: spi1b
Sequence Ontology ID : SO:0000704

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Previous Names: pu.1, pu1, spi1 (1), cb1086 (1), si:by184l24.2

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits sequence-specific DNA binding activity; involved in several processes, including hemopoiesis, negative regulation of cell differentiation, and positive regulation of gene expression;  ...
GENE EXPRESSION
All Expression Data: 169 figures from 111 publications
Directly Submitted Expression Data: 5 figures (10 images) from Thisse et al., 2001 [cb1086]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh509 Small Deletion Exon 4 Unknown CRISPR
hkz4 Point Mutation Unknown Missense ENU
sa16105 Point Mutation Unknown Splice Site, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 24 figures from 21 publications
    Observed in:
    DISEASE ASSOCIATED WITH spi1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH spi1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of neutrophil differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000418 (1)
  • InterPro:IPR036388 (1)
  • InterPro:IPR036390 (1)
  • PROSITE:PS00345 (1)
  • PROSITE:PS00346 (1)
  • PROSITE:PS50061 (1)
  • Pfam:PF00178 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA spi1b-003 (1) 688
    mRNA spi1b-201 (1) 2373
    spi1b-202 (1) 1228
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM spi1b
    MARKER RELATIONSHIPS
    spi1bContained in: [BAC] CH73-314G15 (1) (order this), CH211-150G13 (1) (order this), XX-184L24
    spi1bEncodes: [EST] cb1086 (1) (order this)
    [cDNA] MGC:65932 (1) (order this), MGC:85783 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198062 (1) 1034bp
    Genomic GenBank:AL929252 (1) 173244bp
    Select Tool
    Polypeptide UniProtKB:Q6WEE1 (1) 297aa
    Sequence Clusters UniGene:34508 (1)
    Sequence Information (all 37)
    OTHER spi1b GENE PAGES
  • Alliance (1)
  • Gene:30117 (1)
  • VEGA:OTTDARG00000020186 (1)
  • Ensembl(GRCz11):ENSDARG00000000767 (2)
  • ORTHOLOGY for spi1b (Chr: 7)
    CITATIONS (313)