- Title
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Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
- Authors
- Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W.
- Source
- Full text @ Elife
Tcf7l1a maternal zygotic (MZ) mutants and tcf7l1a morphants have no overt eye phenotype.PHENOTYPE:
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The prospective forebrain and eye field domains of the neural plate are reduced in Ztcf7l1a-/- mutants. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. EXPRESSION / LABELING:
PHENOTYPE:
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Tcf7l1a cell autonomously promotes rx3 expression in the eye field. |
Eye size recovers in Ztcf7l1a-/- mutant and eye vesicle-cell removed embryos. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. PHENOTYPE:
|
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |
Neurogenesis is delayed in small tcf7l1a-/- eyes and accelerated in large eyes following hsp70:dkk1 overexpression. |
Ztcf7l1a mutants show more retinal progenitor cells undergoing proliferation. |
Ztcf7l1a-/- mutants lacking Hesx1 function fail to form eyes.PHENOTYPE:
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Loss of tcf7l1a modifies the cct5u762 mutant eye phenotype. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |
Loss of tcf7l1a modifies the gdf6aU768/U768mutant eye phenotype. |