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ZIRC
ZFIN ID: ZDB-GENE-980526-400
Gene Name: orthodenticle homeobox 1
Gene Symbol: otx1    Nomenclature History

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Previous Names: otx1, otx1b, zOtx1 (1), cb769 (1), fj99f05 (1), wu:fj99f05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in inner ear morphogenesis; lateral semicircular canal development; and retinal pigment epithelium development. Predicted to localize to the nucleus. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and presumptive neural plate. Orthologous to human OTX1 (orthodenticle homeobox 1).
Genome Resources: Alliance (1),  Gene:30500 (1),  Ensembl(GRCz11):ENSDARG00000094992 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa96 Point Mutation Unknown Premature Stop ENU
tud37Gt Transgenic Insertion Exon 4 Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-otx1 N/A 2
MO2-otx1 N/A 1
MO3-otx1 N/A 1
MO4-otx1 N/A 1
DISEASE ASSOCIATED WITH otx1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH otx1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process retinal pigment epithelium development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA otx1-201 (1)    Ensembl 2513
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM otx1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1-LOXP-gata2a:EGFP-5HS4) gata2aotx1 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 2
Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1-LOXP-gata2a:EGFP-5HS4) gata2aotx1 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 2
Tg3(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1-LOXP-gata2a:EGFP-5HS4) gata2aotx1 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 2
TgBAC(otx1:GAL4-VP16,myl7:mCherry) myl7otx1 GAL4mCherryVP16 Danio rerio 1 1
MARKER RELATIONSHIPS
otx1 Contained in: [BAC] DKEYP-74F1 (1)
otx1 Encodes: [EST] cb769 (1) (order this), fj99f05
[cDNA] MGC:55275 (1) (order this), MGC:191298 (1) (order this)
otx1 Has Artifact: [EST] IMAGE:5612640
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131250 (1) 2539 bp
Genomic GenBank:BX649529 (1) 216647 bp Blast at MegaBLAST
Polypeptide UniProtKB:B2GNW8 (1) 323 aa
Sequence Clusters UniGene:30626 (1)
Sequence Information (all 23)
ORTHOLOGY for otx1 ( Chr: 17 )
CITATIONS (98)