header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-128
Gene Name: SIX homeobox 3b
Gene Symbol: six3b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: six3.2, six6 (1), cb347 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic camera-type eye morphogenesis; nervous system development; and sensory epithelium regeneration. Predicted to localize to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Is expressed in several structures, including ectoderm; hypoblast; immature eye; nervous system; and neural keel. Orthologous to human SIX3 (SIX homeobox 3).
Genome Resources: Alliance (1),  Gene:30636 (1),  Ensembl(GRCz11):ENSDARG00000054879 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ja53 Small Deletion Exon 1 Unknown TALEN
ja55 Small Deletion Exon 1 Unknown TALEN
sa24913 Point Mutation Unknown Premature Stop ENU
sa35303 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu87 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-six3a,six3b N/A 4
    MO2-six3b N/A 2
    TALEN1-six3b 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH six3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    holoprosencephaly 2 Alliance Holoprosencephaly 2 157170
    Schizencephaly 269160
    DISEASE ASSOCIATED WITH six3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic camera-type eye morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA six3b-201 (1)    Ensembl 1759
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM six3b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:six3b) six3b Danio rerio 1 3
    MARKER RELATIONSHIPS
    six3b Contained in: [BAC] DKEY-250C11 (1) (order this)
    six3b Encodes: [EST] cb347 (1) (order this), fa01b08
    [cDNA] MGC:73043 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131363 (1) 1722 bp
    Genomic GenBank:CR932018 (1) 137736 bp
    Select Tool
    Polypeptide UniProtKB:O73709 (1) 293 aa
    Sequence Clusters UniGene:75402 (1)
    Sequence Information (all 17)
    ORTHOLOGY for six3b ( Chr: 12 )
    CITATIONS (112)