Gene
barhl2
- ID
- ZDB-GENE-050913-153
- Name
- BarH-like homeobox 2
- Symbol
- barhl2 Nomenclature History
- Previous Names
-
- wu:fq39g04
- zgc:113948
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BARHL2 (BarH like homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu113 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33851 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa | Mediator complex and homeobox domain-containing protein |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6YI96
|
364 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
barhl2-202
(1)
|
Ensembl | 1,711 nt | ||
| ncRNA |
barhl2-002
(1)
|
Ensembl | 766 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(barhl2:GFP) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-15L16 | ZFIN Curated Data | |
| Encodes | EST | eu113 | Thisse et al., 2005 | |
| Encodes | EST | fq39g04 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:113948 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205740 (1) | 1721 nt | ||
| Genomic | GenBank:CR385085 (1) | 211060 nt | ||
| Polypeptide | UniProtKB:Q6YI96 (1) | 364 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Soto, X., Burton, J., Manning, C.S., Minchington, T., Lea, R., Lee, J., Kursawe, J., Rattray, M., Papalopulu, N. (2022) Sequential and additive expression of miR-9 precursors control timing of neurogenesis. Development (Cambridge, England). 149(19):
- Zhang, H., Wang Haifang, H., Shen, X., Jia, X., Yu, S., Qiu, X., Wang, Y., Du, J., Yan, J., He, J. (2021) The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain. eLIFE. 10:
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Tambalo, M., Mitter, R., Wilkinson, D.G. (2020) A single cell transcriptome atlas of the developing zebrafish hindbrain. Development (Cambridge, England). 147(6):
- Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W. (2019) Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE. 8:
- Chen, C., Stedman, A., Havis, E., Anselme, I., Onichtchouk, D., Giudicelli, F., Schneider-Maunoury, S. (2016) Initiation of cyp26a1 Expression in the Zebrafish Anterior Neural Plate by a Novel Cis-Acting Element. PLoS One. 11:e0150639
- Mullally, M., Albrecht, C., Horton, M., Laboissonniere, L.A., Goetz, J.J., Chowdhury, R., Manning, A., Wester, A.K., Bose, Q., Trimarchi, J.M. (2016) Expression Profiling of Developing Zebrafish Retinal Cells. Zebrafish. 13(4):272-80
- Zhang, Y., Bonilla, S., Chong, L., and Leung, Y.F. (2013) Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene expression patterns : GEP. 13(5-6):177-82
- Coolen, M., Thieffry, D., Drivenes, O., Becker, T.S., and Bally-Cuif, L. (2012) miR-9 Controls the Timing of Neurogenesis through the Direct Inhibition of Antagonistic Factors. Developmental Cell. 22(5):1052-1064
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