ZFIN is now using GRCz12tu for Genomic Data

Gene

tcf7l2

ID

ZDB-GENE-991110-8

Name

transcription factor 7 like 2

Symbol

tcf7l2 Nomenclature History

Previous Names

tcf4

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA binding activity. Involved in digestive system development. Acts upstream of or within several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Located in nucleus. Is expressed in several structures, including anterior neural plate; brain; digestive system; gonad; and sensory system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

36 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf7l2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, type 2, susceptibility to}	125853

Associated With tcf7l2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
type 2 diabetes mellitus	tcf7l2^zf55/zf55	standard conditions	Facchinello et al., 2017
type 2 diabetes mellitus	tcf7l2^zf55/+	standard conditions	Facchinello et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Domain	IPR013558	CTNNB1 binding, N-teminal
Family	IPR024940	Transcription factor TCF/LEF
Homologous_superfamily	IPR027397	Catenin binding domain superfamily
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q71G54	InterPro	477
UniProtKB:A0A8M1P7C7	InterPro	477
UniProtKB:A0AB32TXS6	InterPro	613
UniProtKB:A0AB32TXT4	InterPro	490
UniProtKB:A0AB32TXT5	InterPro	615
UniProtKB:A0AB32TXU9	InterPro	493
UniProtKB:A0AB32TYF3	InterPro	605
UniProtKB:A0AB32TYG5	InterPro	438
UniProtKB:A0AB32TZZ8	InterPro	610
UniProtKB:A0AB32U011	InterPro	485
UniProtKB:A0AB32U028	InterPro	635
UniProtKB:A0AB32U041	InterPro	588
UniProtKB:A0AB32U055	InterPro	409
UniProtKB:A0AB32U0K7	InterPro	601
UniProtKB:A0AB32U0M2	InterPro	426
UniProtKB:A0AB32U0X1	InterPro	630
UniProtKB:A0AB32U0Y3	InterPro	588
UniProtKB:A0AB32U153	InterPro	613
UniProtKB:A0AB32U2G1	InterPro	610
UniProtKB:A0AB32U2H3	InterPro	485
UniProtKB:A0AB32U2S2	InterPro	630
UniProtKB:A0AB32U2U0	InterPro	581
UniProtKB:A0AB32U336	InterPro	618
UniProtKB:A0AB32U348	InterPro	502
UniProtKB:A0AB32U3V1	InterPro	630
UniProtKB:A0AB32U3W4	InterPro	571
UniProtKB:A0AB32U413	InterPro	635
UniProtKB:A0AB32U425	InterPro	593
UniProtKB:A0AB32U431	InterPro	618
UniProtKB:A0AB32U435	InterPro	460
UniProtKB:A0AB32U442	InterPro	497
UniProtKB:A0AB32U500	InterPro	625
UniProtKB:A0AC58GUQ3	InterPro	468
UniProtKB:A0AC58GUQ6	InterPro	480
UniProtKB:A0AC58GUR1	InterPro	485
UniProtKB:A0AC58GUR2	InterPro	455
UniProtKB:A0AC58GUR3	InterPro	465
UniProtKB:A0AC58GUR4	InterPro	576
UniProtKB:A0AC58GUR7	InterPro	460
UniProtKB:A0AC58GUR9	InterPro	480
UniProtKB:A0AC58GUS0	InterPro	492
UniProtKB:A0AC58GUS1	InterPro	345
UniProtKB:A0AC58GUS2	InterPro	472
UniProtKB:A0AC58GUS3	InterPro	431
UniProtKB:A0AC58GUS4	InterPro	443
UniProtKB:A0AC58GUS6	InterPro	340
UniProtKB:A0AC58GUS7	InterPro	576
UniProtKB:A0AC58GUS9	InterPro	608
UniProtKB:A0AC58GUT0	InterPro	450
UniProtKB:A0AC58GUT1	InterPro	490
UniProtKB:A0AC58GUT2	InterPro	317
UniProtKB:A0AC58GUT4	InterPro	317
UniProtKB:A0AC58GUT6	InterPro	450
UniProtKB:A0AC58GUT7	InterPro	445
UniProtKB:A0AC58GUT9	InterPro	450
UniProtKB:A0AC58GUU0	InterPro	455
UniProtKB:A0AC58GUU2	InterPro	300
UniProtKB:A0AC58GUU3	InterPro	357
UniProtKB:A0AC58GUU4	InterPro	352
UniProtKB:A0AC58GUU5	InterPro	450
UniProtKB:A0AC58GUU6	InterPro	445
UniProtKB:A0AC58GUU9	InterPro	312
UniProtKB:A0AC58GUV0	InterPro	300
UniProtKB:A0AC58GUW4	InterPro	312

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tcf7l2-201 (1) Ensembl	Ensembl	2,139 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-202 (1) Ensembl	Ensembl	2,022 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-203 (1) Ensembl	Ensembl	2,078 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-204 (1) Ensembl	Ensembl	6,756 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-205 (1) Ensembl	Ensembl	1,986 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-206 (1) Ensembl	Ensembl	2,063 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-208 (1) Ensembl	Ensembl	477 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-209 (1) Ensembl	Ensembl	680 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-210 (1) Ensembl	Ensembl	4,203 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-211 (1) Ensembl	Ensembl	6,807 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-212 (1) Ensembl	Ensembl	6,807 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-213 (1) Ensembl	Ensembl	6,696 nt	Select Tool ZFIN BLAST
ncRNA	tcf7l2-003 (1) Ensembl	Ensembl	631 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tcf7l2	monoclonal	tcf7l2	IgG1	Mouse	IHC	Biomol GmbH	2
Ab2-tcf7l2	monoclonal	tcf7l2	IgG	Rabbit	IHC	Millipore	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations