Gene

tcf7l2

ID

ZDB-GENE-991110-8

Name

transcription factor 7 like 2

Symbol

tcf7l2 Nomenclature History

Previous Names

tcf4

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have beta-catenin binding activity; sequence-specific DNA binding activity; and transcription regulatory region DNA binding activity. Involved in several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Localizes to nucleus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Is expressed in several structures, including anterior neural keel; brain; digestive system; lateral line system; and optic vesicle. Orthologous to human TCF7L2 (transcription factor 7 like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf7l2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, type 2, susceptibility to}	125853

Associated With tcf7l2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
type 2 diabetes mellitus	tcf7l2^zf55/zf55	standard conditions	Facchinello et al., 2017
type 2 diabetes mellitus	tcf7l2^zf55/+	standard conditions	Facchinello et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Domain	IPR013558	CTNNB1 binding, N-teminal
Family	IPR024940	Transcription factor TCF/LEF
Homologous_superfamily	IPR027397	Catenin binding domain superfamily
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	Catenin binding domain superfamily	CTNNB1 binding, N-teminal	High mobility group box domain	High mobility group box domain superfamily	Transcription factor TCF/LEF
UniProtKB:Q71G54 InterPro	477

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tcf7l2-201 (1) Ensembl	Ensembl	2,139 nt	Select Tool
mRNA	tcf7l2-202 (1) Ensembl	Ensembl	2,022 nt	Select Tool
mRNA	tcf7l2-203 (1) Ensembl	Ensembl	2,078 nt	Select Tool
mRNA	tcf7l2-204 (1) Ensembl	Ensembl	6,756 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-205 (1) Ensembl	Ensembl	1,986 nt	Select Tool
mRNA	tcf7l2-206 (1) Ensembl	Ensembl	2,063 nt	Select Tool
mRNA	tcf7l2-208 (1) Ensembl	Ensembl	477 nt	Select Tool
mRNA	tcf7l2-209 (1) Ensembl	Ensembl	680 nt	Select Tool
mRNA	tcf7l2-210 (1) Ensembl	Ensembl	4,203 nt	Select Tool
mRNA	tcf7l2-211 (1) Ensembl	Ensembl	6,807 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-212 (1) Ensembl	Ensembl	6,807 nt	Select Tool ZFIN BLAST
mRNA	tcf7l2-213 (1) Ensembl	Ensembl	6,696 nt	Select Tool ZFIN BLAST
ncRNA	tcf7l2-003 (1) Ensembl	Ensembl	631 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tcf7l2	monoclonal	tcf7l2	IgG1	Mouse	IHC	Biomol GmbH	2
Ab2-tcf7l2	monoclonal	tcf7l2	IgG	Rabbit	IHC	Millipore	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations