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ZIRC
ZFIN ID: ZDB-GENE-980526-406
Gene Name: orthodenticle homeobox 2b
Gene Symbol: otx2b    Nomenclature History

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Previous Names: otx2, zotx-2, zOtx2 (1), etID309955.17 (1), id:ibd2915, zgc:136535

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in brain development; cellular response to alcohol; and retinal pigment epithelium development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in microphthalmia and panhypopituitarism. Is expressed in several structures, including immature eye; nervous system; neural plate; neural rod; and presumptive structure. Orthologous to human OTX2 (orthodenticle homeobox 2).
Genome Resources: Alliance (1), Gene:30501 (1), Ensembl(GRCz11):ENSDARG00000011235 (2)
GENE EXPRESSION
All Expression Data: 238 figures from 171 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd2915]
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3237 Point Mutation Unknown Premature Stop ENU
hu3625 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36505 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tud44a Insertion 5' UTR Unknown CRISPR
    tud44Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-otx2b 2
    MO1-otx2b N/A 7
    MO2-otx2b N/A 2
    MO3-otx2b N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH otx2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypopituitarism Alliance Pituitary hormone deficiency, combined, 6 613986
    microphthalmia Alliance Microphthalmia, syndromic 5 610125
    Retinal dystrophy, early-onset, with or without pituitary dysfunction 610125
    DISEASE ASSOCIATED WITH otx2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to alcohol (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA otx2b-201 (1)    Ensembl 2162
    otx2b-202 (1)    Ensembl 2212
    otx2b-203 (1)    Ensembl 922
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM otx2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(otx2b:Cre-ERT2) otx2b CreERT2 Danio rerio 1 1
    Tg(otx2b:EGFP) otx2b EGFP Danio rerio 1 2
    Tg(otx2b:tRFP) otx2b RFP Danio rerio 1 1
    Tg(otx2b:Venus) otx2b Venus Danio rerio 1 1
    MARKER RELATIONSHIPS
    otx2bContained in: [BAC] DKEY-166F24 (1) (order this)
    otx2bEncodes: [EST] ibd2915 (1) (order this)
    [cDNA] MGC:136535 (1) (order this), MGC:191828 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131251 (1) 2161bp
    Genomic GenBank:CR936482 (1) 39394bp
    Select Tool
    Polypeptide UniProtKB:Q1RM25 (1) 289aa
    Sequence Clusters UniGene:334 (1)
    Sequence Information (all 25)
    ORTHOLOGY for otx2b (Chr: 17)
    CITATIONS (311)