Gene
lef1
- ID
- ZDB-GENE-990714-26
- Name
- lymphoid enhancer-binding factor 1
- Symbol
- lef1 Nomenclature History
- Previous Names
-
- etID310027.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including fin development; fin regeneration; and forebrain development. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in chromatin. Is expressed in several structures, including midbrain hindbrain boundary neural rod; nervous system; neural crest; pleuroperitoneal region; and trunk. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 140 figures from 100 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 31 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013709Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021271Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021272Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021273Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021274Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nl2 | Allele with one insertion | Unknown | Frameshift | ENU | |
| sa10902 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18709 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32764 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39684 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lef1 | Brożko et al., 2022 | |
| MO1-lef1 | N/A | (11) |
| MO2-lef1 | N/A | (10) |
| MO3-lef1 | N/A | (5) |
| MO4-lef1 | N/A | (2) |
| MO5-lef1 | N/A | Gamba et al., 2010 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| anxiety disorder | lef1zd11/zd11 | standard conditions | Xie et al., 2017 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR013558 | CTNNB1 binding, N-teminal |
| Family | IPR024940 | Transcription factor TCF/LEF |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
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Domain Details Per Protein
| Protein | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor TCF/LEF |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9W7C0
|
365 |
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Interactions and Pathways
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:mKOFP2-2A-dnlef1) |
| 1 | Tamaki et al., 2023 | ||
| Tg(lef1:TETAM2-2A-AmCyan) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-5K4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-252L8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193547 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131426 (1) | 2802 nt | ||
| Genomic | GenBank:CR391978 (2) | 137171 nt | ||
| Polypeptide | UniProtKB:Q9W7C0 (1) | 365 aa |
- Camacho-Macorra, C., Tabanera, N., Sánchez-Bustamante, E., Bovolenta, P., Cardozo, M.J. (2024) Maternal vgll4a regulates zebrafish epiboly through Yap1 activity. Frontiers in cell and developmental biology. 12:13626951362695
- Ding, S., Aziz, T., Meng, A., Jia, S. (2024) Aagab is required for zebrafish larval development by regulating neural activity. Journal of genetics and genomics = Yi chuan xue bao. 51(6):630-641
- Olson, H.M., Maxfield, A., Calistri, N.L., Heiser, L.M., Qian, W., Knaut, H., Nechiporuk, A.V. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development (Cambridge, England). 151(1):
- Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Liu, X., Yu, T., Tan, X., Jin, D., Yang, W., Zhang, J., Dai, L., He, Z., Li, D., Zhang, Y., Liao, S., Zhao, J., Zhong, T.P., Liu, C. (2023) Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2. eLIFE. 12:
- Ott, E., Hoff, S., Indorf, L., Ditengou, F.A., Müller, J., Renschler, G., Lienkamp, S.S., Kramer-Zucker, A., Bergmann, C., Epting, D. (2023) A novel role for the chloride intracellular channel protein Clic5 in ciliary function. Scientific Reports. 13:1764717647
- Tamaki, T., Yoshida, T., Shibata, E., Nishihara, H., Ochi, H., Kawakami, A. (2023) Splashed E-box and AP-1 motifs cooperatively drive regeneration response and shape regeneration abilities. Biology Open. 12(2):
- Zhang, R., Ma, Z., Wang, J., Fan, C. (2023) HIF signaling overactivation inhibits lateral line neuromast development through Wnt in zebrafish. Gene. 898:148077
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