Gene

lef1

ID
ZDB-GENE-990714-26
Name
lymphoid enhancer-binding factor 1
Symbol
lef1 Nomenclature History
Previous Names
  • etID310027.1 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in several processes, including animal organ development; fin development; and fin regeneration. Predicted to localize to beta-catenin-TCF complex and nuclear chromatin. Is expressed in several structures, including midbrain hindbrain boundary neural rod; nervous system; neural crest; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).
Genome Resources
Note
None
Expression
All Expression Data
112 figures from 75 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 13 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lef1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sebaceous tumors, somatic
Associated With lef1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Domain IPR013558 CTNNB1 binding, N-teminal
Family IPR024940 Transcription factor TCF/LEF
Family IPR028769 Lymphoid enhancer-binding factor 1
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length Catenin binding domain superfamily CTNNB1 binding, N-teminal High mobility group box domain High mobility group box domain superfamily Lymphoid enhancer-binding factor 1 Transcription factor TCF/LEF
UniProtKB:F6NVS9 133
UniProtKB:A0A0R4II86 364
UniProtKB:Q9W7C0 365
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-lef1 polyclonal Rabbit
  • IHC
  • WB
4
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations