Gene
tcf7l1a
- ID
- ZDB-GENE-980605-30
- Name
- transcription factor 7 like 1a
- Symbol
- tcf7l1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity. Involved in several processes, including cell proliferation in dorsal spinal cord; negative regulation of Wnt signaling pathway; and nervous system development. Localizes to nucleus. Is expressed in several structures, including axis; digestive system; midbrain neural keel; nervous system; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63891 (36 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR013558 | CTNNB1 binding, N-teminal |
| Family | IPR024940 | Transcription factor TCF/LEF |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
Domain Details Per Protein
| Protein | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor TCF/LEF |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9YHE8
|
560 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tcf7l1a-201
(1)
|
Ensembl | 2,695 nt | ||
| mRNA |
tcf7l1a-203
(1)
|
Ensembl | 1,803 nt | ||
| ncRNA |
tcf7l1a-002
(1)
|
Ensembl | 708 nt |
Interactions and Pathways
Plasmids
No data available