Gene

tcf7l1a

ID
ZDB-GENE-980605-30
Name
transcription factor 7 like 1a
Symbol
tcf7l1a Nomenclature History
Previous Names
  • hdl
  • tcf-3 (1)
  • tcf3 (1)
  • tcf3a (1)
  • headless
  • HMG-box transcription factor
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits DNA binding activity. Involved in several processes, including cell proliferation in dorsal spinal cord; negative regulation of Wnt signaling pathway; and nervous system development. Localizes to nucleus. Is expressed in several structures, including axis; digestive system; midbrain neural keel; nervous system; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 18 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcf7l1a Human Ortholog
No data available
Associated With tcf7l1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Domain IPR013558 CTNNB1 binding, N-teminal
Family IPR024940 Transcription factor TCF/LEF
Family IPR028778 Transcription factor 7-like 1
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length Catenin binding domain superfamily CTNNB1 binding, N-teminal High mobility group box domain High mobility group box domain superfamily Transcription factor 7-like 1 Transcription factor TCF/LEF
UniProtKB:Q9YHE8 560
UniProtKB:F1QMG3 431
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations