ZFIN Image: Young et al., 2019, Fig. 9

Image

Figure Caption

Fig. 9

Loss of tcf7l1a modifies the gdf6a^U768/U768mutant eye phenotype.

(A–H) Lateral views of eyes in wildtype (A, E), Ztcf7l1a^-/- (B, F), gdf6a^U768/U768 (C, G) and double gdf6a^U768/U768/Ztcf7l1a^-/- (D, H) embryos at 36hpf (A–D) and 52hpf (E–H). Dorsal up, anterior to left. Arrows indicate the lens. Scale bar = 200 µm. (I) Whole mount fluorescent in situ hybridisation for rx3 and pax2a in wildtype (I), Ztcf7l1a^-/- (J), gdf6a^U768/U768(K) and double gdf6a^U768/U768/Ztcf7l1a^-/- (L) embryos at 10hpf. Dorsal view, anterior up. Arrows point to rx3eye field expression. Scale bar = 100 µm. (M) Eye volume quantification in wildtype (n = 7), Ztcf7l1a^-/- (n = 6), gdf6a^-/-(n = 6) and gdf6a^U768/U768/Ztcf7l1a^-/- double mutant siblings (n = 3) at 36hpf (data in Supplementary file 1R). Single experiment, unpaired t-test. (N) Eye field volume quantification from rx3 fluorescent in situ hybridisation shown in I-L in wildtype (n = 7), Ztcf7l1a^-/- (n = 4), gdf6a^-/-(n = 8) and gdf6a^U768/U768/Ztcf7l1a^-/- double mutant siblings (n = 4) at 10hpf (data in Supplementary file 1S). Single experiment, unpaired t-test.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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Fig. 9

Fig. 9

Loss of tcf7l1a modifies the gdf6aU768/U768mutant eye phenotype.

Loss of tcf7l1a modifies the gdf6a^U768/U768mutant eye phenotype.