Gene
atoh7
- ID
- ZDB-GENE-000926-1
- Name
- atonal bHLH transcription factor 7
- Symbol
- atoh7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within several processes, including positive regulation of neurogenesis; retina layer formation; and swimming behavior. Predicted to be located in axon and perikaryon. Predicted to be active in nucleus. Is expressed in eye and immature eye. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 83 figures from 64 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atoh7 | Di Donato et al., 2016 | |
| CRISPR2-atoh7 | Di Donato et al., 2016 | |
| MO1-atoh7 | N/A | (16) |
| MO2-atoh7 | N/A | Choy et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| persistent hyperplastic primary vitreous | Alliance | Persistent hyperplastic primary vitreous, autosomal recessive | 221900 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR032663 | Transcription factor ATOH7, basic helix-loop-helix |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription factor ATOH7, basic helix-loop-helix |
|---|---|---|---|---|---|
|
UniProtKB:Q8AW52
|
134 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-7atoh7:GAL4-VP16) |
|
| 1 | (31) | |
| Tg(atoh7:GAL4-VP16) |
|
| 1 | (8) | |
| Tg(atoh7:GAP-GFP) |
|
| 1 | (21) | |
| Tg(atoh7:GAP-RFP) |
|
| 1 | (53) | |
| Tg(atoh7:GFP) |
|
| 1 | (59) | |
| Tg2(atoh7:GAL4-VP16) |
|
| 1 | (2) | |
| Tg(5xUAS:atoh7,myl7:Cerulean) |
|
| 1 | Engerer et al., 2021 | |
| Tg(atoh7:EGFP) |
|
| 1 | (3) | |
| Tg(atoh7:GAL4,UAS:GAP-GFP) |
|
| 1 | (3) | |
| Tg(atoh7:GCaMP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51A16 | ZFIN Curated Data | |
| Contained in | BAC | RP71-PACKTRZ | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86897 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131632 (1) | 1031 nt | ||
| Genomic | GenBank:BX530079 (1) | 166397 nt | ||
| Polypeptide | UniProtKB:Q8AW52 (1) | 134 aa |
- Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., Cau, E. (2024) Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. PLoS Genetics. 20:e1011172e1011172
- Emmerich, K., Hageter, J., Hoang, T., Lyu, P., Sharrock, A.V., Ceisel, A., Thierer, J., Chunawala, Z., Nimmagadda, S., Palazzo, I., Matthews, F., Zhang, L., White, D.T., Rodriguez, C., Graziano, G., Marcos, P., May, A., Mulligan, T., Reibman, B., Saxena, M.T., Ackerley, D.F., Qian, J., Blackshaw, S., Horstick, E., Mumm, J.S. (2024) Large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration. Development (Cambridge, England). 151(15):
- Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103
- Ahmed, M., Kojima, Y., Masai, I. (2022) Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation. eLIFE. 11:
- Amini, R., Bhatnagar, A., Schlüßler, R., Möllmert, S., Guck, J., Norden, C. (2022) Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina. eLIFE. 11:
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Schultz-Rogers, L.E., Thayer, M.L., Kambakam, S., Wierson, W.A., Helmer, J.A., Wishman, M.D., Wall, K.A., Greig, J.L., Forsman, J.L., Puchhalapalli, K., Nair, S., Weiss, T.J., Luiken, J.M., Blackburn, P.R., Ekker, S.C., Kool, M., McGrail, M. (2022) Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1267-1290
- Venditti, M., Pedalino, C., Rosello, M., Fasano, G., Serafini, M., Revenu, C., Del Bene, F., Tartaglia, M., Lauri, A. (2022) A minimally invasive fin scratching protocol for fast genotyping and early selection of zebrafish embryos. Scientific Reports. 12:2259722597
- Davison, C., Zolessi, F.R. (2021) Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells & development. 166:203677
- Engerer, P., Petridou, E., Williams, P.R., Suzuki, S.C., Yoshimatsu, T., Portugues, R., Misgeld, T., Godinho, L. (2021) Notch-mediated re-specification of neuronal identity during central nervous system development. Current biology : CB. 31(21):4870-4878.e5
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