Gene
atoh7
- ID
- ZDB-GENE-000926-1
- Name
- atonal bHLH transcription factor 7
- Symbol
- atoh7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including positive regulation of neurogenesis; retina layer formation; and swimming behavior. Is expressed in eye and immature eye. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 78 figures from 60 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| persistent hyperplastic primary vitreous | Alliance | Persistent hyperplastic primary vitreous, autosomal recessive | 221900 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|
|
UniProtKB:Q8AW52
|
134 |
Interactions and Pathways
No data available
Plasmids
No data available