ZFIN ID: ZDB-GENE-050222-4
Gene Name: transcription factor 7
Gene Symbol: tcf7    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in pectoral fin development; regulation of transcription by RNA polymerase II; and spinal cord dorsal/ventral patterning. Predicted to localize to the nucleus and transcription factor complex. Is expressed in several structures, including dermal bone; nervous system; optic cup; pectoral fin bud; and prechordal plate. Orthologous to human TCF7 (transcription factor 7).
Genome Resources: Alliance (1),  Gene:497649 (1),  Ensembl(GRCz11):ENSDARG00000038672 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3238 Point Mutation Exon 2 Premature Stop ENU
nkhg21cEt Transgenic Insertion Unknown Unknown DNA
sa1057 Point Mutation Unknown Splice Site ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-tcf7 N/A 8
MO2-tcf7 N/A 1
PHENOTYPE
Data: 3 figures from 3 publications
Observed in:
DISEASE ASSOCIATED WITH tcf7 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tcf7 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription by RNA polymerase II (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Domain IPR013558 CTNNB1 binding, N-teminal
Family IPR024940 Transcription factor TCF/LEF
Family IPR028785 Transcription factor 7
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Homologous_superfamily IPR036910 High mobility group box domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tcf7-201 (1)    Ensembl 803
tcf7-202 (1)    Ensembl 924
tcf7-203 (1)    Ensembl 939
tcf7-204 (1)    Ensembl 767
tcf7-205 (1)    Ensembl 792
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tcf7 No data available
MARKER RELATIONSHIPS
tcf7 Contained in: [BAC] CH73-202G8 (1)
tcf7 Encodes: [cDNA] MGC:194208 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001012389 (1) 1349 nt
Genomic GenBank:CU639470 (1) 114638 nt
Select Tool
Polypeptide UniProtKB:Q5PU93 (1) 355 aa
Sequence Information (all 30)
ORTHOLOGY for tcf7 ( Chr: 21 )
CITATIONS (57)