ZFIN ID: ZDB-GENE-990415-238
Gene Name: retinal homeobox gene 3
Gene Symbol: rx3    Nomenclature History

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Previous Names: chk, chokh, eyes missing (1), eym (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in animal organ development and cell fate specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Is expressed in several structures, including forebrain; neural keel; neural plate; presumptive neural plate; and retina. Orthologous to human RAX (retina and anterior neural fold homeobox).
Genome Resources: Alliance (1),  Gene:30474 (1),  Ensembl(GRCz11):ENSDARG00000052893 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu499 Point Mutation Unknown Missense ENU
ne2611 Point Mutation Exon 2 Missense ENU
rx3_unspecified Unspecified Unknown Unknown
s399 Point Mutation Unknown Premature Stop ENU
sa29528 Point Mutation Unknown Splice Site ENU
t25181 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t25327 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • w29 Point Mutation Exon 2 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rx3
    1
    CRISPR2-rx3
    1
    MO1-rx3 N/A 3
    MO2-rx3 N/A 2
    MO3-rx3 N/A 2
    DISEASE ASSOCIATED WITH rx3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    isolated microphthalmia 3 Alliance Microphthalmia, isolated 3 611038
    DISEASE ASSOCIATED WITH rx3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rx3-201 (1)    Ensembl 1411
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rx3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(rx3:Kaede) rx3 Kaede Danio rerio 1 1
    MARKER RELATIONSHIPS
    rx3 Contained in: [BAC] CH211-233A1 (1)
    rx3 Encodes: [cDNA] MGC:195183 (1), MGC:195186 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131227 (1) 1322 nt
    Genomic GenBank:BX248399 (1) 158884 nt
    Select Tool
    Polypeptide UniProtKB:A8E7H4 (1) 292 aa
    Sequence Information (all 16)
    ORTHOLOGY for rx3 ( Chr: 21 )
    CITATIONS (116)